-Adrenergic Signaling in Heart Failure

Heart Failure ◽  
2004 ◽  
pp. 93-114
Keyword(s):  
Heart Failure ◽  
Adrenergic Signaling

Changes of β-adrenergic signaling in compensated human cardiac hypertrophy depend on the underlying disease

2000 ◽  
Vol 278 (6) ◽  
pp. H2076-H2083 ◽  
Author(s):  
Ulrich Schotten ◽  
Karsten Filzmaier ◽  
Britta Borghardt ◽  
Simone Kulka ◽  
Friedrich Schoendube ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiac Hypertrophy ◽  
G Protein ◽  
Adrenergic System ◽  
Plasma Catecholamine ◽  
Human Heart Failure ◽  
Α Subunit ◽  
Adrenergic Signaling ◽  
G Protein Α Subunit ◽  
Catecholamine Levels

In human heart failure, desensitization of the β-adrenergic signal transduction has been reported to be one of the main pathophysiological alterations. However, data on the β-adrenergic system in human compensated cardiac hypertrophy are very limited. Therefore, we studied the myocardial β-adrenergic signaling in patients suffering from hypertrophic obstructive cardiomyopathy (HOCM, n = 9) or from aortic valve stenosis (AoSt, n = 8). β-Adrenoceptor density determined by [125I]iodocyanopindolol binding was reduced in HOCM and AoSt compared with nonhypertrophied, nonfailing myocardium (NF) of seven organ donors. In HOCM the protein expression of stimulatory G protein α-subunit (Gsα) measured by immunoblotting was unchanged, whereas the inhibitory G protein α-subunit (Gαi-2) was increased. In contrast, in AoSt, Gαi-2 protein was unchanged, but Gsα protein was increased. Adenylyl cyclase stimulation by isoproterenol was reduced in HOCM but not in AoSt. Plasma catecholamine levels were normal in all patients. In conclusion, both forms of hypertrophy are associated with β-adrenoceptor downregulation but with different changes at the G protein level that occur before symptomatic heart failure due to progressive dilatation of the left ventricle develops and are not due to elevated plasma catecholamine levels.

scholarly journals Mitochondria in β-adrenergic signaling: emerging therapeutic perspectives in heart failure and ventricular arrhythmias

2018 ◽  
Vol 10 (S33) ◽  
pp. S4183-S4185 ◽  
Author(s):  
Christos Kontogiannis ◽  
Marinos Kosmopoulos ◽  
Georgios Georgiopoulos ◽  
Michael Spartalis ◽  
Ioannis Paraskevaidis ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ventricular Arrhythmias ◽  
Adrenergic Signaling

scholarly journals Adrenergic signaling in heart failure and cardiovascular aging

Maturitas ◽  
2016 ◽  
Vol 93 ◽  
pp. 65-72 ◽  
Author(s):  
Gaetano Santulli ◽  
Guido Iaccarino
Keyword(s):  
Heart Failure ◽  
Adrenergic Signaling ◽  
Cardiovascular Aging

Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure

2001 ◽  
Vol 15 (10) ◽  
pp. 1718-1726 ◽  
Author(s):  
HIDEAKI SENZAKI ◽  
CAROLYN J. SMITH ◽  
GEORGE J. JUANG ◽  
TAKAYOSHI ISODA ◽  
SHARON P. MAYER ◽  
...  
Keyword(s):  
Heart Failure ◽  
Adrenergic Signaling ◽  
Phosphodiesterase 5
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