scholarly journals Over-expression of microRNA-145 drives alterations in β-adrenergic signaling and attenuates cardiac remodeling in heart failure post myocardial infarction

Aging ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 11603-11622
Author(s):  
Zhebo Liu ◽  
Bo Tao ◽  
Suzhen Fan ◽  
Shengyu Cui ◽  
Yong Pu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Cardiac Remodeling ◽  
Post Myocardial Infarction ◽  
Adrenergic Signaling ◽  
Over Expression

scholarly journals Adenosine receptors as therapeutic targets for the treatment of myocardial infarction and its complications. Part II. Post-myocardial infarction heart failure and arrhythmias

2019 ◽  
Vol 65 (3) ◽  
Author(s):  
Kamila Puchałowicz ◽  
Krzysztof Safranow ◽  
Monika Rać ◽  
Dariusz Chlubek ◽  
Violetta Dziedziejko
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Adenosine Receptor ◽  
Cardiac Remodeling ◽  
Post Myocardial Infarction ◽  
Adenosine Receptor Agonists ◽  
Receptor Agonists ◽  
Receptor Agonists And Antagonists ◽  
Infarction Heart

For many years, researchers have studied the cardioprotective properties of adenosine and attempted to use the compound in the treatment of myocardial infarction. Adenosine exhibits many other effects, as well, which can be helpful in treating complications of myocardial infarction. Over the last decade, the results of over a dozen studies conducted on animal models evaluating the possibility of using adenosine receptor agonists and antagonists in the prevention and treatment of chronic heart failure and arrhythmias after myocardial infarction have been published. This is particularly important in view of the increasing number of patients suffering from such complications, associated with increased survival rates among patients due to advancements in diagnosis and treatment of myocardial infarction itself. Current treatments for chronic heart failure and arrhythmias are mainly symptomatic and frequently are not satisfactorily effective. Cardiac remodeling, an important mechanism behind the pathogenesis of post-myocardial infarction heart failure and arrhythmias, is a promising therapeutic target. This review presents current reports on the use of adenosine receptor agonists and antagonists as modulators of cardiac remodeling in post-myocardial infarction heart failure and arrhythmias.

Levosimendan improves contractilityin vivoandin vitroin a rodent model of post-myocardial infarction heart failure

2014 ◽  
Vol 210 (4) ◽  
pp. 865-874 ◽  
Author(s):  
S. M. Kolseth ◽  
N. P. L. Rolim ◽  
Ø. Salvesen ◽  
D. O. Nordhaug ◽  
A. Wahba ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Rodent Model ◽  
Post Myocardial Infarction ◽  
Infarction Heart
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