Radiology of the normal breast and differential diagnosis of benign breast lesions

2013 ◽  
pp. 135-147
Author(s):  
Jessica Kuehn-Hajder ◽  
Claudia Engeler ◽  
Tim Emory
Keyword(s):  
Differential Diagnosis ◽  
Normal Breast ◽  
Breast Lesions ◽  
Benign Breast Lesions

Approach to the Patient with a Breast Mass

2019 ◽  
Author(s):  
George Plitas ◽  
Monica Morrow ◽  
Brandon R Bruns
Keyword(s):  
Breast Cancer ◽  
Differential Diagnosis ◽  
Diagnostic Procedures ◽  
Needle Aspiration ◽  
Breast Mass ◽  
Breast Lesions ◽  
Breast Clinic ◽  
Breast Masses ◽  
Diagnosis And Management ◽  
Benign Breast Lesions

A breast mass is the most common presenting symptom among patients in a breast clinic. The presence of a breast mass can cause a great deal of anxiety in women, as well as their physicians. The differential diagnosis of a palpable breast abnormality is broad, although the majority of breast masses are benign. The responsibility of the physician who is evaluating a breast mass is to exclude the presence of malignancy. Once cancer is ruled out, the physician should then attempt to provide an accurate diagnosis, appropriate treatment, and reassurance to the patient. This chapter discusses the assessment of normal breast physiology, identification of a breast mass, evaluation of the various classifications of breast mass (e.g., dominant mass with clinically benign features and dominant mass with suspicious features), differential diagnosis and management of common benign breast masses (e.g., cysts, fibroadenomas, phyllodes tumors, hamartomas, fat necrosis), and the risk of breast cancer associated with benign breast lesions. The chapter also discusses the diagnosis and management of a breast mass in male patients. Tables outline breast lesions that may present as a palpable abnormality, factors used for the assessment of breast cancer risk, physical characteristics of benign and malignant breast masses, the accuracy of fine-needle aspiration, and benign breast lesions by category. Figures illustrate diagnostic procedures, the anatomy of the human breast, visual inspection of the breasts, physical examination of the breasts, breast palpation technique, the evaluation and management of a new breast mass, and the identification of cysts. This review contains 10 figures, 14 tables, and 64 references. Keywords: breast mass, lobuloalveolar development, subareolar nodularity, parenchyma (glandular elements), stromal tissue, ovarian graafian follicles

scholarly journals Diagnostic usefulness of water-to-fat ratio and choline concentration in malignant and benign breast lesions and normal breast parenchyma: An in vivo 1H MRS study

2011 ◽  
Vol 33 (4) ◽  
pp. 855-863 ◽  
Author(s):  
Sunitha B. Thakur ◽  
Sandra B. Brennan ◽  
Nicole M. Ishill ◽  
Elizabeth A. Morris ◽  
Laura Liberman ◽  
...  
Keyword(s):  
Normal Breast ◽  
Breast Lesions ◽  
1H Mrs ◽  
Breast Parenchyma ◽  
Diagnostic Usefulness ◽  
Benign Breast Lesions

Approach to the Patient with a Breast Mass

2019 ◽  
Author(s):  
George Plitas ◽  
Monica Morrow ◽  
Brandon R Bruns
Keyword(s):  
Breast Cancer ◽  
Differential Diagnosis ◽  
Diagnostic Procedures ◽  
Needle Aspiration ◽  
Breast Mass ◽  
Breast Lesions ◽  
Breast Clinic ◽  
Breast Masses ◽  
Diagnosis And Management ◽  
Benign Breast Lesions

A breast mass is the most common presenting symptom among patients in a breast clinic. The presence of a breast mass can cause a great deal of anxiety in women, as well as their physicians. The differential diagnosis of a palpable breast abnormality is broad, although the majority of breast masses are benign. The responsibility of the physician who is evaluating a breast mass is to exclude the presence of malignancy. Once cancer is ruled out, the physician should then attempt to provide an accurate diagnosis, appropriate treatment, and reassurance to the patient. This chapter discusses the assessment of normal breast physiology, identification of a breast mass, evaluation of the various classifications of breast mass (e.g., dominant mass with clinically benign features and dominant mass with suspicious features), differential diagnosis and management of common benign breast masses (e.g., cysts, fibroadenomas, phyllodes tumors, hamartomas, fat necrosis), and the risk of breast cancer associated with benign breast lesions. The chapter also discusses the diagnosis and management of a breast mass in male patients. Tables outline breast lesions that may present as a palpable abnormality, factors used for the assessment of breast cancer risk, physical characteristics of benign and malignant breast masses, the accuracy of fine-needle aspiration, and benign breast lesions by category. Figures illustrate diagnostic procedures, the anatomy of the human breast, visual inspection of the breasts, physical examination of the breasts, breast palpation technique, the evaluation and management of a new breast mass, and the identification of cysts. This review contains 10 figures, 14 tables, and 64 references. Keywords: breast mass, lobuloalveolar development, subareolar nodularity, parenchyma (glandular elements), stromal tissue, ovarian graafian follicles

Loss of heterozygosity in normal breast epithelial tissue and benign breast lesions in BRCA1/2 carriers with breast cancer

2004 ◽  
Vol 149 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Luciane R Cavalli ◽  
Baljit Singh ◽  
Claudine Isaacs ◽  
Robert B Dickson ◽  
Bassem R Haddad
Keyword(s):  
Breast Cancer ◽  
Loss Of Heterozygosity ◽  
Normal Breast ◽  
Epithelial Tissue ◽  
Breast Lesions ◽  
Benign Breast Lesions ◽  
Breast Epithelial

Thymidylate Synthase, a New Myoepithelial Biomarker for Breast Lesions

2019 ◽  
Vol 27 (8) ◽  
pp. 852-858
Author(s):  
Rui Guo ◽  
Yi Tian ◽  
Xueyuan Jin ◽  
Xiaozhong Huang ◽  
Jun Yang
Keyword(s):  
Differential Diagnosis ◽  
Thymidylate Synthase ◽  
Stromal Cells ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Myoepithelial Cells ◽  
Normal Breast ◽  
Breast Lesions ◽  
Breast Tissues

Background. The identification of myoepithelial cells (MECs) can facilitate the differential diagnosis of breast lesions. We previously found thymidylate synthase (TS) expression in the nuclei of MECs in breast tissues, which prompted us to investigate the usefulness of TS as a sensitive and specific biomarker in the differential diagnosis of breast lesions, similar to other MEC biomarkers (ie, tumor protein [P63] and cluster of differentiation 10 [CD10]). Methods. Immunohistochemistry for TS, P63, and CD10 was performed on paraffin sections from 189 breast specimens. Results. The results showed the intensity of the immunoreactive TS signal to be comparable with that of P63 in the nuclei of MECs. Furthermore, the nuclei of MECs stained strongly for TS and P63 in normal breast tissues (obtained adjacent to invasive breast lesions), benign breast lesions, and carcinoma in situ, whereas the cytoplasm of MECs stained strongly for CD10. The immunoreactive TS signal in the cytoplasm of MECs was variable in 22 out of 32 (65.6%) cases of invasive breast carcinoma and 4 out of 20 cases (20.0%) of ductal carcinoma in situ. We found no immunoreactive TS signal in the nuclei of luminal and stromal cells in breast lesions, although there was a weak positive signal in the cytoplasm of luminal and stromal cells. Conclusions. TS is a sensitive and specific MEC biomarker in the differential diagnosis of breast lesions.

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