Carbohydrate-Derived Self-Crosslinkable In Situ Gelable Hydrogels for Modulation of Wound Healing

2013 ◽  
pp. 739-782
Author(s):  
Lihui Weng ◽  
Christine Falabella ◽  
Weiliam Chen
Keyword(s):  
Wound Healing

scholarly journals Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xinchen Du ◽  
Le Wu ◽  
Hongyu Yan ◽  
Zhuyan Jiang ◽  
Shilin Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Shape Recovery ◽  
Parenchymal Cell ◽  
Gelatin Sponge ◽  
Defect Model ◽  
Liver Parenchymal Cell ◽  
E Coli ◽  
Tissue Integration ◽  
3D Printed

AbstractDeveloping an anti-infective shape-memory hemostatic sponge able to guide in situ tissue regeneration for noncompressible hemorrhages in civilian and battlefield settings remains a challenge. Here we engineer hemostatic chitosan sponges with highly interconnective microchannels by combining 3D printed microfiber leaching, freeze-drying, and superficial active modification. We demonstrate that the microchannelled alkylated chitosan sponge (MACS) exhibits the capacity for water and blood absorption, as well as rapid shape recovery. We show that compared to clinically used gauze, gelatin sponge, CELOX™, and CELOX™-gauze, the MACS provides higher pro-coagulant and hemostatic capacities in lethally normal and heparinized rat and pig liver perforation wound models. We demonstrate its anti-infective activity against S. aureus and E. coli and its promotion of liver parenchymal cell infiltration, vascularization, and tissue integration in a rat liver defect model. Overall, the MACS demonstrates promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing.

scholarly journals Hydrogen Peroxide Generation of Copper/Ascorbate Formulations on Cotton: Effect on Antibacterial and Fibroblast Activity for Wound Healing Application

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2399 ◽  
Author(s):  
J. Edwards ◽  
Nicolette Prevost ◽  
Michael Santiago ◽  
Terri von Hoven ◽  
Brian Condon ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Wound Healing ◽  
Cotton Fiber ◽  
Cotton Effect ◽  
Aqueous Environment ◽  
Amplex Red ◽  
Low Levels ◽  
Icp Analysis ◽  
Hydrogen Peroxide Generation

Greige cotton (unbleached cotton) is an intact plant fiber that retains much of the outer cotton fiber layers. These layers contain pectin, peroxidases, and trace metals that are associated with hydrogen peroxide (H2O2) generation during cotton fiber development. When greige cotton is subjected to a nonwoven hydroentanglement process, components of the outer cotton fiber layers are retained. When hydrated, this fabric can generate H2O2 (5–50 micromolar). This range has been characterized as inducing accelerated wound healing associated with enhanced cell signaling and the proliferation of cells vital to wound restoration. On the other hand, H2O2 levels above 50 micromolar have been associated with bacteriostatic activity. Here, we report the preparation and hydrogen peroxide activity of copper/ascorbate formulations, both as adsorbed and in situ synthesized analogs on cotton. The cooper/ascorbate-cotton formulations were designed with the goal of modulating hydrogen peroxide levels within functional ranges beneficial to wound healing. The cotton/copper formulation analogs were prepared on nonwoven unbleached cotton and characterized with cotton impregnation titers of 3–14 mg copper per gram of cotton. The copper/ascorbate cotton analog formulations were characterized spectroscopically, and the copper titer was quantified with ICP analysis and probed for peroxide production through assessment with Amplex Red. All analogs demonstrated antibacterial activity. Notably, the treatment of unbleached cotton with low levels of ascorbate (~2 mg/g cotton) resulted in a 99 percent reduction in Klebsiella pneumoniae and Staphylococcus aureus. In situ synthesized copper/ascorbate nanoparticles retained activity and did not leach out upon prolonged suspension in an aqueous environment. An assessment of H2O2 effects on fibroblast proliferation are discussed in light of the copper/cotton analogs and wound healing.

In Situ Electrospinning Wound Healing Films Composed of Zein and Clove Essential Oil

2020 ◽  
Vol 305 (3) ◽  
pp. 1900790 ◽  
Author(s):  
Mei Qin ◽  
Xiao‐Ju Mou ◽  
Wen‐Hao Dong ◽  
Jia‐Xu Liu ◽  
Hao Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Essential Oil ◽  
Clove Essential Oil

scholarly journals New BMSC-Laden Gelatin Hydrogel Formed in Situ by Dual-Enzymatic Cross-Linking Accelerates Dermal Wound Healing

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 8334-8340 ◽  
Author(s):  
Minghao Yao ◽  
Junni Zhang ◽  
Feng Gao ◽  
Yihao Chen ◽  
Shanshan Ma ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cross Linking ◽  
Dermal Wound Healing ◽  
Gelatin Hydrogel ◽  
Dermal Wound

Moist-Retaining, Self-Recoverable, Bioadhesive, and Transparent in Situ Forming Hydrogels To Accelerate Wound Healing

2020 ◽  
Vol 12 (2) ◽  
pp. 2023-2038 ◽  
Author(s):  
Jun Li ◽  
Fan Yu ◽  
Gong Chen ◽  
Jia Liu ◽  
Xiao-Long Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Accelerate Wound Healing ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

The in situ synthesis of Ag/amino acid biopolymer hydrogels as mouldable wound dressings

2015 ◽  
Vol 51 (87) ◽  
pp. 15862-15865 ◽  
Author(s):  
Zhenzhu Zhang ◽  
Ting He ◽  
Mengying Yuan ◽  
Rujuan Shen ◽  
Liu Deng ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amino Acid ◽  
In Situ Synthesis ◽  
Wound Dressings ◽  
Supramolecular Hydrogel ◽  
Green Strategy

Monodispersed AgNPs were in situ fabricated in a hybrid supramolecular hydrogel via a green strategy. The as-prepared nanocomposite has been proved to be a mouldable wound healing biomaterial.

Mesenchymal Stem Cell Spheroids Embedded in an Injectable Thermosensitive Hydrogel: An In Situ Drug Formation Platform for Accelerated Wound Healing

2020 ◽  
Vol 6 (9) ◽  
pp. 5096-5109
Author(s):  
Mohammad Ali Nilforoushzadeh ◽  
Mohsen Khodadadi Yazdi ◽  
Shaghayegh Baradaran Ghavami ◽  
Samila Farokhimanesh ◽  
Leila Mohammadi Amirabad ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Thermosensitive Hydrogel ◽  
Cell Spheroids
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