Control of tuberculosis in low-prevalence countries

2008 ◽  
pp. 431-456
Author(s):  
Daniel Sagebiel
Keyword(s):  
Low Prevalence

Prevalence and geographic distribution of haemophilia in Costa Rica

2010 ◽  
Vol 30 (S 01) ◽  
pp. S28-S31 ◽  
Author(s):  
J. Arroyo ◽  
L. Salazar-Sánchez ◽  
G. Jiménez-Cruz ◽  
P. Chaverri ◽  
E. Arrieta-Bolaños ◽  
...  
Keyword(s):  
Costa Rica ◽  
Survival Rates ◽  
Coagulation Factors ◽  
Developed Countries ◽  
Health Centers ◽  
Distribution Analysis ◽  
Distribution Maps ◽  
Immunodeficiency Virus ◽  
The Many ◽  
Low Prevalence

SummaryHaemophilia is the most frequent hereditary haemorrhagic illness and it is due to the deficiency of coagulation factors VIII (haemophilia A, HA) or IX (haemophilia B, HB).The prevalence of this disease varies according to the country, those having better survival rates having also higher prevalences. Specifically in Costa Rica, there are around 130 HA and 30 HB families. This study reports the prevalence and a spatial distribution analysis of both types of the disease in this country. The prevalence of haemophilia in this country is 7 cases per 100 000 men, for HA it is 6 cases per 100 000 and for HB it is 1 case per 100 000 male inhabitants. The prevalence of this disease is low when compared with other populations. This low prevalence could be due to the many patients that have died because of infection with human immunodeficiency virus during the 1980s. The prevalence of haemophilia in Costa Rica is almost one half of that present in developed countries. Nevertheless, the ratio between HA and HB follows world tendency: 5 : 1. In this study, nationwide geographical distribution maps were drawn in order to visualize the origin of severe cases and how this influences the pattern of distribution for both types of haemophilia. By means of these maps, it was possible to state that there is no association between the sites of maximum prevalence of mutated alleles and ethnicity. With this study, haemophilia prevalence distribution maps can be used to improve efforts for the establishment of hemophilia clinics or specialized health centers in those areas which hold the highest prevalences in this country. Also, this knowledge can be applied to improve treatment skills and offer the possibility of developing focused genetic counseling for these populations.

Prevalence of Factor V Leiden Mutation in Non-European Populations

1997 ◽  
Vol 77 (02) ◽  
pp. 329-331 ◽  
Author(s):  
Guglielmina Pepe ◽  
Olga Rickards ◽  
Olga Camacho Vanegas ◽  
Tamara Brunelli ◽  
Anna Maria Gori ◽  
...  
Keyword(s):  
Factor V Leiden ◽  
Indirect Evidence ◽  
Factor V ◽  
Factor V Leiden Mutation ◽  
The World ◽  
Fv Leiden ◽  
Sub Saharan ◽  
Low Prevalence ◽  
European Populations ◽  
Apparently Healthy

SummaryA difference in the prevalence of venous thromboembolism (TE) in major human groups has been described and an uneven distribution of FV Leiden mutation over the world has recently been reported.We investigated FV Leiden mutation in 584 apparently healthy sub#jects mostly from populations different from those previously investi#gated: 170 Europeans (Spanish, Italians), 101 sub-saharan Africans (Fon, Bariba, Berba, Dendi), 115 Asians (Indonesians, Chinese, Tharus), 57 Amerindians (Cayapa), 84 Afroamericans (Rio Cayapa, Viche), and 57 Ethiopians (Amhara, Oromo).The mutation was detected in only 1/115 Asian (Tharu) and in 5/170 Europeans (4 Italians, 1 Spanish).These data confirm that in non-Europeans the prevalence of FV mutation is at least 7 times lower than in Europeans and provide indirect evidence of a low prevalence not only of the FV Leiden gene but also of other genes leading to more severe thrombophilia. Finally, findings from the literature together with those pertaining to this study clearly show a marked heterogeneity among Europeans.

199-LB: Low Prevalence of Small-for-Gestational-Age in Women with Type 1 Diabetes and Chronic Hypertension

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 199-LB
Author(s):  
SARIT HELMAN ◽  
TAMARRA JAMES-TODD ◽  
FLORENCE M. BROWN
Keyword(s):  
Type 1 Diabetes ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Chronic Hypertension ◽  
Low Prevalence

Staphylococcus aureus Nasal Carriage in Medical Students of Universiti Teknologi MARA

2017 ◽  
Vol 2 (1) ◽  
pp. 29 ◽  
Author(s):  
Zaini Mohd Zain ◽  
Muhammad Fikri Johari ◽  
Nurul Shahirah Mohd Husin ◽  
Nurul Syamimi Rozman ◽  
Athirah Ab Rashid ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Medical Students ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Nasal Carriage ◽  
Tissue Necrosis ◽  
Mannitol Salt Agar ◽  
Microbiological Techniques ◽  
Polymerase Chain ◽  
Low Prevalence ◽  
Panton Valentine Leukocidin

Introduction: To determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage and detection of S. aureus leukotoxins among medical students of Universiti Teknologi MARA. Methods: Both sides of the anterior nares of 136 volunteers, comprising 68 preclinical and 68 clinical medical students, were swabbed and immediately cultured onto mannitol salt agar for growth of S. aureus. Standard microbiological techniques were conducted to identify and confirm the S. aureus colonies and susceptibility test against oxacillin were conducted by using Kirby-Bauer method to determine their resistance to methicillin. Polymerase chain reaction was performed for detection of leukotoxins, i.e., Panton-Valentine Leukocidin (PVL) and -haemolysin genes. Results: Nineteen students (14%) consisting of 10 preclinical (14.7%) and 9 clinical (13.2%) were nasal carriers of S. aureus. However, none of the S. aureus isolates were MRSA. No PVL gene was detected but eight of them were positive for -haemolysin gene. Conclusion: There were no MRSA nasal carriers among the medical students, but a low prevalence of S. aureus nasal carriers was detected. These carriers do not pose as high risk because none of the strains of S. aureus possess both the -haemolysin toxin and the PVL toxin that are associated with tissue necrosis.

Work-related musculoskeletal disorders in highway sanitary workers

2015 ◽  
Author(s):  
Happiness Anulika Aweto ◽  
Oluwatoyosi Babatunde Owoeye ◽  
Korede Sunday Adegbite
Keyword(s):  
Musculoskeletal Disorders ◽  
Body Part ◽  
Sudden Onset ◽  
Work Related ◽  
Significant Relationships ◽  
Lower Back ◽  
Gradual Onset ◽  
Work Related Musculoskeletal Disorders ◽  
The Mean ◽  
Low Prevalence

Background: Highway sanitary workers are exposed to various health hazards in the course of duty. This study investigated the prevalence of work-related musculoskeletal disorders (WMSDs) among highway sanitary workers in Lagos Waste Management Authority (LAWMA), Lagos, Nigeria.Method: Two hundred fifty highway sanitary workers (46 males and 204 females) of LAWMA selected from four Local Government Areas of Lagos State, Nigeria completed a 26-item questionnaire that collected information on WMSDs.Results: The 12-month prevalence of WMSDs among the workers was 24.8%. The most commonly affected body part was the lower back (22.0%). Thirty-seven (59.7%) of the respondents reported gradual onset of musculoskeletal disorders (MSDs) while 25 (40.3%) reported sudden onset. The mean years of working experience was 3.22 + 0.23 years with 111 (44.4%) of the respondents having worked for 4 years and 7 (2.8%) having worked for 1year. The three major job risk factors identified were: continuing to work when injured (87.2%), working in the same position for long periods (53.6%) and lifting heavy materials (52.4%). Pearson’s Product Moment Correlation Coefficient analysis showed that there were significant relationships between prevalence of WMSDs and age (r = 0.42, p = 0.001*) and years on the job (r = 0.17, p = 0.01*).Conclusion: There was a low prevalence of WMSDs among highway sanitary workers of LAWMA. The most commonly affected body part was the lower back. Increasing age and years of working experience are significant factors that can contribute to the development of WMSDs among these workers.

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