Stem cell therapies for Alzheimer’s disease and other dementias

Dementia ◽  
2010 ◽  
pp. 528-533
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies

scholarly journals P2-006: STEM CELL THERAPIES FOR ALZHEIMER'S DISEASE: IS IT TIME?

2019 ◽  
Vol 15 ◽  
pp. P573-P573
Author(s):  
Sheng-Min Wang ◽  
Chang Uk Lee ◽  
Hyun Kook Lim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies

Stem cell therapies for Alzheimer's disease

2019 ◽  
Vol 32 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Sheng-Min Wang ◽  
Chang-Uk Lee ◽  
Hyun Kook Lim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies

Stem Cell-based Therapeutic and Diagnostic Approaches in Alzheimer's Disease

2021 ◽  
Vol 20 ◽  
Author(s):  
Sadaf Abdi ◽  
Nima Javanmehr ◽  
Maryam Ghasemi-Kasman ◽  
Hanie Yavarpour Bali ◽  
Marzieh Pirzadeh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Clinical Trials ◽  
Stem Cell ◽  
Memory Loss ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Advantages And Disadvantages ◽  
Diagnostic Approaches

Background: Alzheimer’s disease (AD) is a neurodegenerative impairment mainly recognized by memory loss and cognitive deficits. However, the current therapies against AD are mostly limited to palliative medications, prompting researchers to investigate more efficient therapeutic approaches for AD, such as stem cell therapy. Recent evidence has proposed that extensive neuronal and synaptic loss and altered adult neurogenesis, which is perceived pivotal in terms of plasticity and network maintenance, occurs early in the course of AD, which exacerbates neuronal vulnerability to AD. Thus, regeneration and replenishing the depleted neuronal networks by strengthening the endogenous repair mechanisms or exogenous stem cells and their cargoes is a rational therapeutic approach. Currently, several stem cell-based therapies as well as stem cell products like exosomes, have shown promising results in the early diagnosis of AD. Objective: This review begins with a comparison between AD and normal aging pathophysiology and a discussion on open questions in the field. Next, summarizing the current stem cell-based therapeutic and diagnostic approaches, we declare the advantages and disadvantages of each method. Also, we comprehensively evaluate the human clinical trials of stem cell therapies for AD. Methodology: Peer-reviewed reports were extracted through Embase, PubMed, and Google Scholar until 2021. Results: With several ongoing clinical trials, stem cells and their derivatives (e.g., exosomes) are an emerging and encouraging field in diagnosing and treating neurodegenerative diseases. Although stem cell therapies have been successful in animal models, numerous clinical trials in AD patients have yielded unpromising results, which we will further discuss.

scholarly journals Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-30 ◽  
Author(s):  
Ankit Tandon ◽  
Sangh Jyoti Singh ◽  
Rajnish Kumar Chaturvedi
Keyword(s):  
Multiple Sclerosis ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Stem Cell ◽  
Therapeutic Effects ◽  
Potential Candidate ◽  
Behavioral Deficits ◽  
Cell Therapies ◽  
Proliferation And Differentiation

Alzheimer’s disease (AD) and multiple sclerosis are major neurodegenerative diseases, which are characterized by the accumulation of abnormal pathogenic proteins due to oxidative stress, mitochondrial dysfunction, impaired autophagy, and pathogens, leading to neurodegeneration and behavioral deficits. Herein, we reviewed the utility of plant polyphenols in regulating proliferation and differentiation of stem cells for inducing brain self-repair in AD and multiple sclerosis. Firstly, we discussed the genetic, physiological, and environmental factors involved in the pathophysiology of both the disorders. Next, we reviewed various stem cell therapies available and how they have proved useful in animal models of AD and multiple sclerosis. Lastly, we discussed how polyphenols utilize the potential of stem cells, either complementing their therapeutic effects or stimulating endogenous and exogenous neurogenesis, against these diseases. We suggest that polyphenols could be a potential candidate for stem cell therapy against neurodegenerative disorders.

scholarly journals Analysis on Stem cell Treatment of Alzheimer's Disease

2021 ◽  
Vol 271 ◽  
pp. 03072
Author(s):  
Weixun Zhu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Neurodegenerative Diseases ◽  
Cell Transplantation ◽  
Memory Loss ◽  
Cell Therapies ◽  
Stem Cell Treatment

Alzheimer's disease is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment. At present, conventional drugs have little effect on the prevention and treatment of AD, and the rapidly developing stem cell transplantation therapy provides a new direction for the treatment of neurodegenerative diseases. In this paper, we can conclude that stem cell therapies such as neural stem cells and mesenchymal stem cells have shown curative effects in the treatment of neurodegenerative diseases such as Alzheimer’s disease by analyzing existing stem cell research and analysis at this stage, and there will be huge applications in the future. prospect. Stem cells can secrete immunoregulatory factors through paracrine pathways to inhibit inflammation and reduce the accumulation of amyloid. Secrete neurotrophic factors to protect and promote nerve growth. In addition, stem cells can differentiate into neurons after transplantation, replacing damaged and dead nerve cells, and play an important role in rebuilding brain neural circuits and networks. This article analyzes and summarizes the possible ways of stem cell transplantation to treat Alzheimer's disease, which can provide new ideas and methods for future stem cell transplantation therapies.

Sternal bone marrow is a suitable autologous cell source for cardiac stem cell therapies

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
M. Arar ◽  
A. Rotärmel ◽  
A.-K. Knoefel ◽  
H. Baraki ◽  
I. Kutschka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cardiac Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Autologous Cell ◽  
Cell Source
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