Critical limb ischemia results in different types of endothelial dysfunction depending on the vascular bed studied

Endovascular invasions for femoral-popliteal segment disorders of C andD-type according to TASC-II classification

Endovascular Neuroradiology ◽

10.26683/2304-9359-2018-2(24)-69-76 ◽

2018 ◽

Vol 24 (2) ◽

pp. 69-76

Author(s):

O.L. Nikishin ◽

M.I. Muz ◽

A.I. Gavretskiy ◽

I.V. Altman ◽

S.I. Savoluk

Keyword(s):

Peripheral Arterial Disease ◽

Critical Limb Ischemia ◽

Limb Ischemia ◽

Arterial Disease ◽

Vascular Bed ◽

Number Of Patients ◽

Surgical Methods ◽

Peripheral Arterial ◽

Surgical Treatments ◽

Medical Recommendations

Currently, direct re-vascularization for the management of critical limb ischemia (CLI) is effectuated through open and hybrid surgical treatments. At the same time, therapeutic recommendations for one of the methods appear as a subject of lasting discussions. Today TASC II (TransAtlantic Inter-Society Consensus for the Management of Peripheral Arterial Disease) adopted in 2007 is the most popular document that provides justifications for endovascular and surgical treatment of peripheral arterial disease. Clinical practice provides evidence that there is a significant number of patients having critical limb ischemia who suffer from vascular bed disorders and are classified as C or D-type according to TASC classification. Meanwhile, there also are cases when these patients have no other alternative than re-vascularization by means of open surgery, which is why endovascular invasion appears as the only method of re-vascularization for them. The article presents some results of comparative studies within endovascular and surgical tools aimed at revascularization in the area of femoral-popliteal segment, including cases where patients are classified as C and D-type. The results of shunting operations are compared to angioplasty and remote endarterectomy, whereas technical methods for re-entry during subintimal angioplasty are regarded apart. Despite the fact that there are medical recommendations for the use of endovascular and surgical methods depending on TASC II classification, today there is no evidence that these tools can be efficient in revascularization of femoral-popliteal segment. In order to identify the efficiency of distinct methods in revascularization of femoral-popliteal segment there a need in a number of extended randomized studies designed to evaluate the role of such factors, as anatomic location of the vascular bed disorder, the extent of a disease, the location of purolo-necrotic areas as well as other pathologies on the results of the study.

Download Full-text