Dual-Functional Zwitterionic Carboxybetaine for Highly Sensitive and Speci‡c Cancer Biomarker Detection in Complex Media Using SPR Biosensors

2012 ◽  
pp. 94-113
Keyword(s):  
Cancer Biomarker ◽  
Biomarker Detection ◽  
Complex Media ◽  
Dual Functional ◽  
Highly Sensitive

Cubic CeO2implanted reduced graphene oxide-based highly sensitive biosensor for non-invasive oral cancer biomarker detection

2018 ◽  
Vol 6 (19) ◽  
pp. 3000-3012 ◽  
Author(s):  
Namrata Pachauri ◽  
Kashyap Dave ◽  
Amit Dinda ◽  
Pratima R. Solanki
Keyword(s):  
Graphene Oxide ◽  
Oral Cancer ◽  
Reduced Graphene Oxide ◽  
Cerium Oxide ◽  
Cancer Biomarker ◽  
Electrochemical Technique ◽  
Biomarker Detection ◽  
Non Invasive ◽  
Reduced Graphene ◽  
Highly Sensitive

Herein, we report a cerium oxide nanocubes (ncCeO2)–reduced graphene oxide (RGO)-based nanocomposite for the detection of oral cancer biomarker, cytokeratin fragment-21-1 (Cyfra-21-1), using the electrochemical technique.

scholarly journals Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection

Chemosensors ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 85
Author(s):  
Anton Popov ◽  
Benediktas Brasiunas ◽  
Asta Kausaite-Minkstimiene ◽  
Almira Ramanaviciene
Keyword(s):  
Signal Amplification ◽  
Electrochemical Immunosensor ◽  
Metal Nanoparticle ◽  
Biomarker Detection ◽  
Analytical Instruments ◽  
Electrochemical Immunosensors ◽  
Highly Sensitive ◽  
Recent Developments ◽  
Electrochemical Signal ◽  
Detection Of Biomarkers

With the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (MNPs) and quantum dots (Qdots) as tags are overviewed, focusing on recent developments in the ultrasensitive detection of biomarkers. MNPs and Qdots can be used separately or in combination with other nanostructures, while performing the function of nanocarriers, electroactive labels, or catalysts. Thus, different functions of MNPs and Qdots as well as recent advances in electrochemical signal amplification are discussed. Additionally, the methods most often used for antibody immobilization on nanoparticles, immunoassay formats, and electrochemical methods for indirect biomarker detection are overviewed.

scholarly journals Optical multiplexed bioassays on photonic crystals for breast cancer biomarker detection

2021 ◽  
Vol 255 ◽  
pp. 13003
Author(s):  
Tommaso Pileri ◽  
Alberto Sinibaldi ◽  
Agostino Occhicone ◽  
Elena Giordani ◽  
Matteo Allegretti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Specific Interaction ◽  
Fluorescence Emission ◽  
Optical Biosensor ◽  
Cancer Biomarker ◽  
Time Development ◽  
Biomarker Detection ◽  
Label Free ◽  
One Dimensional ◽  
Protein Bovine Serum Albumin

An optical biosensor for proteomic breast cancer biomarker detection in complex media is presented. Bloch Surface Waves (BSW) excited onto one dimensional photonic crystal (1DPC) were used to probe the interaction of HER2 with three antibody species and an inert protein (Bovine Serum Albumin - BSA). The optical system combines Label-Free readings to track the bioassay real-time development and Fluorescence emission quantification to evaluate the level of specific interaction between the antigen and the antibodies. The results confirm a distinguishable level of affinity between the antibodies and the analyte according to their specificity even at low antibody surface density (about 1173 pg/mm2).

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