Smart Biomaterial Scaffold for In Situ Tissue Regeneration

2012 ◽  
pp. 79-100
Author(s):  
Jaehyun Kim ◽  
Sunyoung Joo ◽  
In Ko ◽  
Anthony Atala ◽  
James Yoo ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Biomaterial Scaffold

scholarly journals Comprehensive proteomic atlas of skin biomatrix scaffolds reveals a supportive microenvironment for epidermal development

2020 ◽  
Vol 11 ◽  
pp. 204173142097231
Author(s):  
Ling Leng ◽  
Jie Ma ◽  
Xuer Sun ◽  
Baolin Guo ◽  
Fanlu Li ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Limited Success ◽  
Biomaterial Scaffold ◽  
Biomaterial Scaffolds ◽  
Scaffold Materials ◽  
Ecm Architecture ◽  
And Function ◽  
Epidermal Development

Biomaterial scaffolds are increasingly being used to drive tissue regeneration. The limited success so far in human tissues rebuilding and therapy application may be due to inadequacy of the functionality biomaterial scaffold. We developed a new decellularized method to obtain complete anatomical skin biomatrix scaffold in situ with extracellular matrix (ECM) architecture preserved, in this study. We described a skin scaffold map by integrated proteomics and systematically analyzed the interaction between ECM proteins and epidermal cells in skin microenvironment on this basis. They were used to quantify structure and function of the skin’s Matrisome, comprised of core ECM components and ECM-associated soluble signals that are key regulators of epidermal development. We especially revealed that ECM played a role in determining the fate of epidermal stem cells through hemidesmosome components. These concepts not only bring us a new understanding of the role of the skin ECM niche, they also provide an attractive combinational strategy based on tissue engineering principles with skin biomatrix scaffold materials for the acceleration and enhancement of tissue regeneration.

Layered Gradient Nonwovens of In Situ Crosslinked Electrospun Collagenous Nanofibers Used as Modular Scaffold Systems for Soft Tissue Regeneration

2013 ◽  
Vol 23 (26) ◽  
pp. 3277-3285 ◽  
Author(s):  
Marco Angarano ◽  
Simon Schulz ◽  
Martin Fabritius ◽  
Robert Vogt ◽  
Thorsten Steinberg ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

scholarly journals In situ tissue regeneration using a novel tissue-engineered, small-caliber vascular graft without cell seeding

2008 ◽  
Vol 136 (4) ◽  
pp. 900-907 ◽  
Author(s):  
Takenori Yokota ◽  
Hajime Ichikawa ◽  
Goro Matsumiya ◽  
Toru Kuratani ◽  
Taichi Sakaguchi ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Vascular Graft ◽  
Cell Seeding

Biomaterials for in situ tissue regeneration: development and perspectives

2015 ◽  
Vol 3 (46) ◽  
pp. 8921-8938 ◽  
Author(s):  
Qian Li ◽  
Lie Ma ◽  
Changyou Gao
Keyword(s):  
Tissue Regeneration ◽  
Fundamental Importance ◽  
Powerful Method ◽  
Tissue Defects

Biomaterials are of fundamental importance to in situ tissue regeneration, which has emerged as a powerful method to treat tissue defects. The development and perspectives of biomaterials for in situ tissue regeneration were summarized.

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