Biomaterials for in situ tissue regeneration: development and perspectives

2015 ◽  
Vol 3 (46) ◽  
pp. 8921-8938 ◽  
Author(s):  
Qian Li ◽  
Lie Ma ◽  
Changyou Gao
Keyword(s):  
Tissue Regeneration ◽  
Fundamental Importance ◽  
Powerful Method ◽  
Tissue Defects

Biomaterials are of fundamental importance to in situ tissue regeneration, which has emerged as a powerful method to treat tissue defects. The development and perspectives of biomaterials for in situ tissue regeneration were summarized.

Layered Gradient Nonwovens of In Situ Crosslinked Electrospun Collagenous Nanofibers Used as Modular Scaffold Systems for Soft Tissue Regeneration

2013 ◽  
Vol 23 (26) ◽  
pp. 3277-3285 ◽  
Author(s):  
Marco Angarano ◽  
Simon Schulz ◽  
Martin Fabritius ◽  
Robert Vogt ◽  
Thorsten Steinberg ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

2020 ◽  
pp. 153473462092162
Author(s):  
T. S. Shanmugarajan ◽  
N. Kalai Selvan ◽  
Varuna Naga Venkata Arjun Uppuluri
Keyword(s):  
Wound Healing ◽  
Tissue Regeneration ◽  
Macrophage Polarization ◽  
Negative Control ◽  
Skin Tissue ◽  
Self Healing ◽  
Full Thickness ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Tissue Defects

Full-thickness burns pose a major challenge for clinicians to handle because of their restricted self-healing ability. Even though several approaches have been implemented for repairing these burnt skin tissue defects, all of them had unsatisfactory outcomes. Moreover, during recent years, skin tissue engineering techniques have emerged as a promising approach to improve skin tissue regeneration and overcome the shortcomings of the traditional approaches. Although previous literatures report the wound healing effects of the squalene oil, in the current study, for the first time, we developed a squalene-loaded emulgel-based scaffold as a novel approach for potential skin regeneration. This squalene-loaded agar-based emulgel scaffold was fabricated by using physical cross-linking technique using lecithin as an emulsifier. Characterization studies such as X-ray diffraction, Fourier-transform infrared spectroscopy, and field emission scanning electron microscopy revealed the amorphous nature, chemical interactions, and cross-linked capabilities of the developed emulgel scaffold. The squalene-loaded emulgel scaffold showed excellent wound contraction when compared with the agar gel and negative control. In case of the histopathology and recent immunohistochemistry findings, it was clearly evidenced that squalene-loaded emulgel promoted faster rate of the revascularization and macrophage polarization in order to enhance the burn wound healing. Moreover, the findings also revealed that the incorporation of squalene oil into the formulation enhances collagen deposition and accelerates the burnt skin tissue regeneration process. Finally, we conclude that the squalene-loaded emulgel scaffold could be an effective formulation used in the treatment of the burnt skin tissue defects.

scholarly journals Applications of Fat Grafting in Pediatric Patients

2020 ◽  
Vol 34 (01) ◽  
pp. 053-058
Author(s):  
Linden Shih ◽  
Amjed Abu-Ghname ◽  
Matthew J. Davis ◽  
Amy S. Xue ◽  
Robert F. Dempsey ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Pediatric Patients ◽  
Fat Grafting ◽  
Soft Tissue Defects ◽  
Autologous Fat Grafting ◽  
Reconstructive Procedures ◽  
Autologous Fat ◽  
Pediatric Setting ◽  
Pediatric Populations ◽  
Tissue Defects

AbstractAutologous fat grafting has become a widely utilized technique for a variety of cosmetic and reconstructive procedures. Its potential for volume restoration and tissue regeneration has made it a popular method for treating soft tissue defects in both adult and pediatric populations. While autologous fat grafting in the pediatric setting is not as well characterized as it is in the adult setting, various reports have demonstrated the safety and utility of its applications in nonadult patient populations. In this article, we present the first comprehensive review of the current applications of autologous fat grafting in pediatric patients. Specific challenges to fat grafting in the pediatric setting and future applications will also be discussed.

scholarly journals In situ tissue regeneration using a novel tissue-engineered, small-caliber vascular graft without cell seeding

2008 ◽  
Vol 136 (4) ◽  
pp. 900-907 ◽  
Author(s):  
Takenori Yokota ◽  
Hajime Ichikawa ◽  
Goro Matsumiya ◽  
Toru Kuratani ◽  
Taichi Sakaguchi ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Vascular Graft ◽  
Cell Seeding
Sign in / Sign up

Export Citation Format

Share Document