Electrical Stimulation of Brain Tissue with Carbon Nanofi ber Microbrush Arrays

2012 ◽  
pp. 54-56 ◽  
Keyword(s):  
Electrical Stimulation ◽  
Brain Tissue ◽  
Stimulation Of

scholarly journals The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) Version 2.0: Modelling in vitro electrical stimulation of brain tissue

2019 ◽  
Vol 4 ◽  
pp. 20
Author(s):  
Christopher Thornton ◽  
Frances Hutchings ◽  
Marcus Kaiser
Keyword(s):  
Electrical Stimulation ◽  
Brain Tissue ◽  
Neural Activity ◽  
Long Term Potentiation ◽  
Neuronal Circuits ◽  
Electrode Recording ◽  
Extracellular Potentials ◽  
Stimulation Of ◽  
Virtual Electrode

Neuronal circuits can be modelled in detail allowing us to predict the effects of stimulation on individual neurons. Electrical stimulation of neuronal circuits in vitro and in vivo excites a range of neurons within the tissue and measurements of neural activity, e.g the local field potential (LFP), are again an aggregate of a large pool of cells. The previous version of our Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) allowed for the simulation of the LFP generated by a patch of brain tissue. Here, we extend VERTEX to simulate the effect of electrical stimulation through a focal electric field. We observe both direct changes in neural activity and changes in synaptic plasticity. Testing our software in a model of a rat neocortical slice, we determine the currents contributing to the LFP, the effects of paired pulse stimulation to induce short term plasticity (STP), and the effect of theta burst stimulation (TBS) to induce long term potentiation (LTP).

ELECTRICAL STIMULATION OF NEURAL-DIFFERENTIATING iPSCs ON NOVEL COAXIAL ELECTROCONDUCTIVE NANOFIBERS

2021 ◽  
Author(s):  
Fábio F. F. Garrudo ◽  
Diogo Nogueira ◽  
Carlos André Rodrigues ◽  
Flávio Ferreira ◽  
Patrizia Paradiso ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Electrical Stimulation ◽  
Brain Tissue ◽  
Neurological Diseases ◽  
Stimulation Of

Replenishing neurons may represent the best therapy for, otherwise progressive and fatal, neurological diseases. Clinical trials show that cell integration in a patient’s brain tissue is limited by poor cell...

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