ELECTRICAL STIMULATION OF NEURAL-DIFFERENTIATING iPSCs ON NOVEL COAXIAL ELECTROCONDUCTIVE NANOFIBERS

2021 ◽  
Author(s):  
Fábio F. F. Garrudo ◽  
Diogo Nogueira ◽  
Carlos André Rodrigues ◽  
Flávio Ferreira ◽  
Patrizia Paradiso ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Electrical Stimulation ◽  
Brain Tissue ◽  
Neurological Diseases ◽  
Stimulation Of

Replenishing neurons may represent the best therapy for, otherwise progressive and fatal, neurological diseases. Clinical trials show that cell integration in a patient’s brain tissue is limited by poor cell...

scholarly journals The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) Version 2.0: Modelling in vitro electrical stimulation of brain tissue

2019 ◽  
Vol 4 ◽  
pp. 20
Author(s):  
Christopher Thornton ◽  
Frances Hutchings ◽  
Marcus Kaiser
Keyword(s):  
Electrical Stimulation ◽  
Brain Tissue ◽  
Neural Activity ◽  
Long Term Potentiation ◽  
Neuronal Circuits ◽  
Electrode Recording ◽  
Extracellular Potentials ◽  
Stimulation Of ◽  
Virtual Electrode

Neuronal circuits can be modelled in detail allowing us to predict the effects of stimulation on individual neurons. Electrical stimulation of neuronal circuits in vitro and in vivo excites a range of neurons within the tissue and measurements of neural activity, e.g the local field potential (LFP), are again an aggregate of a large pool of cells. The previous version of our Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) allowed for the simulation of the LFP generated by a patch of brain tissue. Here, we extend VERTEX to simulate the effect of electrical stimulation through a focal electric field. We observe both direct changes in neural activity and changes in synaptic plasticity. Testing our software in a model of a rat neocortical slice, we determine the currents contributing to the LFP, the effects of paired pulse stimulation to induce short term plasticity (STP), and the effect of theta burst stimulation (TBS) to induce long term potentiation (LTP).

scholarly journals An MRI Compatible Brain Probe for Signal Recording and Deep Brain Stimulation

2018 ◽  
Author(s):  
Corey Cruttenden ◽  
Mahdi Ahmadi ◽  
Xiao-Hong Zhu ◽  
Wei Chen ◽  
Rajesh Rajamani
Keyword(s):  
Electrical Stimulation ◽  
Brain Stimulation ◽  
Neurological Diseases ◽  
Neural Tissue ◽  
Electrical Brain Stimulation ◽  
Thalamic Nuclei ◽  
Disease Therapy ◽  
Signal Recording ◽  
Deep Brain ◽  
Stimulation Of

Electrical stimulation of neural tissue is a promising therapy for a variety of neurological diseases. For example, electrical stimulation of deep thalamic nuclei has been used extensively to treat symptoms of Parkinson’s disease, and there is growing interest in treating other conditions including epilepsy and depression with similar techniques. However, the mechanisms of electrical brain stimulation for disease therapy are not fully understood [1].

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