Mass Spectrometry–Based Techniques for Studying Nucleic Acid/Small Molecule Interactions

2016 ◽  
pp. 86-109
Keyword(s):  
Mass Spectrometry ◽  
Nucleic Acid ◽  
Small Molecule ◽  
Molecule Interactions

scholarly journals Insights into cancer severity from biomolecular interaction mechanisms

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Francesco Raimondi ◽  
Gurdeep Singh ◽  
Matthew J. Betts ◽  
Gordana Apic ◽  
Ranka Vukotic ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
High Throughput Sequencing ◽  
Somatic Mutations ◽  
Interaction Data ◽  
Cancer Genes ◽  
Histological Subtypes ◽  
Biomolecular Interaction ◽  
Cancer Mutations ◽  
Molecule Interactions

Abstract To attain a deeper understanding of diseases like cancer, it is critical to couple genetics with biomolecular mechanisms. High-throughput sequencing has identified thousands of somatic mutations across dozens of cancers, and there is a pressing need to identify the few that are pathologically relevant. Here we use protein structure and interaction data to interrogate nonsynonymous somatic cancer mutations, identifying a set of 213 molecular interfaces (protein-protein, -small molecule or –nucleic acid) most often perturbed in cancer, highlighting several potentially novel cancer genes. Over half of these interfaces involve protein-small-molecule interactions highlighting their overall importance in cancer. We found distinct differences in the predominance of perturbed interfaces between cancers and histological subtypes and presence or absence of certain interfaces appears to correlate with cancer severity.

scholarly journals Nucleic Acid Stability in Glycine Betaine Solutions: Correlating Small Molecule Interactions with Nucleic Acid Surfaces

2011 ◽  
Vol 100 (3) ◽  
pp. 57a
Author(s):  
Jeffrey J. Schwinefus ◽  
Elliot Schmidt ◽  
James Kohler ◽  
Alexandra Thomas
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
Glycine Betaine ◽  
Acid Stability ◽  
Molecule Interactions

Pre-equilibration kinetic size-exclusion chromatography with mass spectrometry detection (peKSEC-MS) for label-free solution-based kinetic analysis of protein–small molecule interactions

The Analyst ◽  
2015 ◽  
Vol 140 (4) ◽  
pp. 990-994 ◽  
Author(s):  
Jiayin Bao ◽  
Svetlana M. Krylova ◽  
Leonid T. Cherney ◽  
J. C. Yves Le Blanc ◽  
Patrick Pribil ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Kinetic Analysis ◽  
Small Molecule ◽  
Size Exclusion ◽  
Free Solution ◽  
Label Free ◽  
Mass Spectrometry Detection ◽  
Reversible Binding ◽  
Exclusion Chromatography ◽  
Molecule Interactions

Label-free solution-based kinetic analysis of reversible binding between protein and small molecule.

Nucleic acid-small molecule interactions. VII. Further characterization of deoxyribonucleic acid-diamino steroid complexes

Biochemistry ◽  
1968 ◽  
Vol 7 (4) ◽  
pp. 1568-1582 ◽  
Author(s):  
Henry R. Mahler ◽  
Gerald. Green ◽  
Robert. Goutarel ◽  
. Khuong-Huu-Qui
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
Deoxyribonucleic Acid ◽  
Molecule Interactions
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