Nucleic acid-small molecule interactions. VII. Further characterization of deoxyribonucleic acid-diamino steroid complexes

Biochemistry ◽  
1968 ◽  
Vol 7 (4) ◽  
pp. 1568-1582 ◽  
Author(s):  
Henry R. Mahler ◽  
Gerald. Green ◽  
Robert. Goutarel ◽  
. Khuong-Huu-Qui
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
Deoxyribonucleic Acid ◽  
Molecule Interactions

scholarly journals NMR characterization of RNA small molecule interactions

Methods ◽  
2019 ◽  
Vol 167 ◽  
pp. 66-77 ◽  
Author(s):  
Rhese D. Thompson ◽  
Jared T. Baisden ◽  
Qi Zhang
Keyword(s):  
Small Molecule ◽  
Nmr Characterization ◽  
Molecule Interactions

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

2016 ◽  
Vol 29 (6) ◽  
pp. 281-291 ◽  
Author(s):  
Bankala Krishnarjuna ◽  
San Sui Lim ◽  
Shane M. Devine ◽  
Cael O. Debono ◽  
Raymond Lam ◽  
...  
Keyword(s):  
Small Molecule ◽  
Apical Membrane ◽  
Solution Nmr ◽  
Apical Membrane Antigen 1 ◽  
Apical Membrane Antigen ◽  
Nmr Characterization ◽  
Molecule Interactions

scholarly journals Insights into cancer severity from biomolecular interaction mechanisms

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Francesco Raimondi ◽  
Gurdeep Singh ◽  
Matthew J. Betts ◽  
Gordana Apic ◽  
Ranka Vukotic ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
High Throughput Sequencing ◽  
Somatic Mutations ◽  
Interaction Data ◽  
Cancer Genes ◽  
Histological Subtypes ◽  
Biomolecular Interaction ◽  
Cancer Mutations ◽  
Molecule Interactions

Abstract To attain a deeper understanding of diseases like cancer, it is critical to couple genetics with biomolecular mechanisms. High-throughput sequencing has identified thousands of somatic mutations across dozens of cancers, and there is a pressing need to identify the few that are pathologically relevant. Here we use protein structure and interaction data to interrogate nonsynonymous somatic cancer mutations, identifying a set of 213 molecular interfaces (protein-protein, -small molecule or –nucleic acid) most often perturbed in cancer, highlighting several potentially novel cancer genes. Over half of these interfaces involve protein-small-molecule interactions highlighting their overall importance in cancer. We found distinct differences in the predominance of perturbed interfaces between cancers and histological subtypes and presence or absence of certain interfaces appears to correlate with cancer severity.

scholarly journals Nucleic Acid Stability in Glycine Betaine Solutions: Correlating Small Molecule Interactions with Nucleic Acid Surfaces

2011 ◽  
Vol 100 (3) ◽  
pp. 57a
Author(s):  
Jeffrey J. Schwinefus ◽  
Elliot Schmidt ◽  
James Kohler ◽  
Alexandra Thomas
Keyword(s):  
Nucleic Acid ◽  
Small Molecule ◽  
Glycine Betaine ◽  
Acid Stability ◽  
Molecule Interactions

Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis

2017 ◽  
Vol 8 (9) ◽  
pp. 2088-2095 ◽  
Author(s):  
Emily Fisher ◽  
Yanyan Zhao ◽  
Robert Richardson ◽  
Malgorzata Janik ◽  
Alexander K. Buell ◽  
...  
Keyword(s):  
Small Molecule ◽  
Protein Aggregates ◽  
Microscale Thermophoresis ◽  
Molecule Interactions
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