Cobalt Complex Based on Cyclam for Reversible Binding of Nitric Oxide

2016 ◽  
pp. 286-307
Keyword(s):  
Nitric Oxide ◽  
Cobalt Complex ◽  
Reversible Binding

Cobalt complex based on cyclam for reversible binding of nitric oxide

2008 ◽  
Vol 34 (10-15) ◽  
pp. 909-921 ◽  
Author(s):  
O. Siri ◽  
A. Tabard ◽  
P. Pullumbi ◽  
R. Guilard
Keyword(s):  
Nitric Oxide ◽  
Cobalt Complex ◽  
Reversible Binding

Reversible binding of nitric oxide and carbon monoxide to iron porphyrins. Assessment of the role of the protein in hemoglobin

1973 ◽  
Vol 95 (12) ◽  
pp. 4087-4089 ◽  
Author(s):  
Dennis V. Stynes ◽  
H. Cleary. Stynes ◽  
Brian R. James ◽  
James A. Ibers
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Iron Porphyrins ◽  
Reversible Binding

An unusual hemoprotein capable of reversible binding of nitric oxide from the gram-positive Bacillus halodenitrificans

1994 ◽  
Vol 162 (5) ◽  
pp. 316-322 ◽  
Author(s):  
Gerard Denariaz ◽  
Paul A. Ketchum ◽  
William J. Payne ◽  
Ming-Yih Liu ◽  
Jean LeGall ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gram Positive ◽  
Reversible Binding

Mechanistic Studies on the Reversible Binding of Nitric Oxide to Metmyoglobin

2001 ◽  
Vol 123 (2) ◽  
pp. 285-293 ◽  
Author(s):  
Leroy E. Laverman ◽  
Alicja Wanat ◽  
Janusz Oszajca ◽  
Grazyna Stochel ◽  
Peter C. Ford ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mechanistic Studies ◽  
Reversible Binding

IN VIVO AND IN VITRO EVALUATION OF ANTI-CANCER ACTIVITY OF NEWLY SYNTHESIZED COBALT COMPLEX OF COUMARIN SCHIFF BASES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (04) ◽  
pp. 61-69
Author(s):  
A. Rayaji ◽  
A. H. M. Viswanatha Swamy ◽  
Keyword(s):  
Nitric Oxide ◽  
Hepg2 Cell ◽  
Cobalt Complex ◽  
Reducing Ability ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Hepg2 Cell Lines ◽  
Cancer Activity

Hepatocarcinogenesis is a multistep process involving different genetic alterations that ultimately lead to malignant transformation of the hepatocytes. Modern treatment of cancer includes chemotherapy, hormone therapy, radiotherapy and surgery but they are associated with several adverse effects such as alopecia, fatigue and general weakening of the body’s immune system due to bone marrow suppression. However, there is a continual need to look out for newer drugs to overcome the menace of cancer. In view of this we synthesized the new Coumarin-Cobalt complex derivatives. Structures of all the newly synthesized metal complexes are supported by Spectral data such as IR, NMR, and mass spectrometry. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity by in vivo anticancer activity (BrdU estimation). Immunohistochemical analysis has been done by BrdU and the synthesized compounds were screened for anti-oxidant activity and in vitro HepG2 cell lines. The IC50 values of the HepG2 cell lines as compared with that of standard Cisplatin and compounds IIIb, IIId, IIIe, IIIh and IIIj showed appreciable activity at a concentration less than 10 μG. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity. Anti-oxidant activity performed by Nitric oxide reducing ability, Superoxide dismutase and reducing activity:Compounds IIIc, IIIe and IIIg showed appreciable activity at 400μg/mL and 800 μg/mL screened by nitric oxide reducing ability, superoxide anion was effectively scavenged by compound IIIg at 400μg/mL and 800 μg/mL and reducing power of compounds IIIc and IIIj is comparable with standard ascorbic acid at concentrations 400μg/mL and 800 μg/mL.

An unusual hemoprotein capable of reversible binding of nitric oxide from the gram-positive Bacillus halodenitrificans

1994 ◽  
Vol 162 (5) ◽  
pp. 316-322 ◽  
Author(s):  
Gerard Denariaz ◽  
P. A. Ketchum ◽  
William J. Payne ◽  
Ming-Yih Liu ◽  
J. LeGall ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gram Positive ◽  
Reversible Binding

scholarly journals Reversible binding of nitric oxide to an Fe(iii) complex of a tetra-amido macrocycle

2012 ◽  
Vol 48 (98) ◽  
pp. 11981 ◽  
Author(s):  
Michael D. Pluth ◽  
Stephen J. Lippard
Keyword(s):  
Nitric Oxide ◽  
Reversible Binding
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