Reversible binding of nitric oxide and carbon monoxide to iron porphyrins. Assessment of the role of the protein in hemoglobin

1973 ◽  
Vol 95 (12) ◽  
pp. 4087-4089 ◽  
Author(s):  
Dennis V. Stynes ◽  
H. Cleary. Stynes ◽  
Brian R. James ◽  
James A. Ibers
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Iron Porphyrins ◽  
Reversible Binding

scholarly journals The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

2020 ◽  
Vol 10 ◽  
Author(s):  
Md. Aejazur Rahman ◽  
Joel N. Glasgow ◽  
Sajid Nadeem ◽  
Vineel P. Reddy ◽  
Ritesh R. Sevalkar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Hydrogen Sulfide ◽  
Host Immunity ◽  
Microbial Pathogens ◽  
Microbial Pathogenesis ◽  
Enzymatic Production ◽  
Growth And Survival ◽  
Wide Range

For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathological processes. Hence, H2S is considered a gasotransmitter along with nitric oxide (•NO) and carbon monoxide (CO). Surprisingly, despite having overlapping functions with •NO and CO, the role of host H2S in microbial pathogenesis is understudied and represents a gap in our knowledge. Given the numerous reports that followed the discovery of •NO and CO and their respective roles in microbial pathogenesis, we anticipate a rapid increase in studies that further define the importance of H2S in microbial pathogenesis, which may lead to new virulence paradigms. Therefore, this review provides an overview of sulfide chemistry, enzymatic production of H2S, and the importance of H2S in metabolism and immunity in response to microbial pathogens. We then describe our current understanding of the role of host-derived H2S in tuberculosis (TB) disease, including its influences on host immunity and bioenergetics, and on Mycobacterium tuberculosis (Mtb) growth and survival. Finally, this review discusses the utility of H2S-donor compounds, inhibitors of H2S-producing enzymes, and their potential clinical significance.

The role of mixing in burner-generated carbon monoxide and nitric oxide

1972 ◽  
Vol 19 (3) ◽  
pp. 407-418 ◽  
Author(s):  
Francesco Pompei ◽  
John B. Heywood
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide

Role of nitric oxide system in hydroxyl radical generation in rat striatum due to carbon monoxide poisoning, as determined by microdialysis

Toxicology ◽  
2007 ◽  
Vol 239 (1-2) ◽  
pp. 136-143 ◽  
Author(s):  
Shuichi Hara ◽  
Toshiji Mukai ◽  
Kunihiko Kurosaki ◽  
Hajime Mizukami ◽  
Fumi Kuriiwa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Hydroxyl Radical ◽  
Carbon Monoxide Poisoning ◽  
Oxide System ◽  
Rat Striatum ◽  
Radical Generation ◽  
Nitric Oxide System

Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits

2016 ◽  
Vol 92 ◽  
pp. 3-6 ◽  
Author(s):  
Sumeyya Akyol ◽  
Sevda Yuksel ◽  
Sultan Pehlivan ◽  
Haci Kemal Erdemli ◽  
Mehmet Akif Gulec ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Carbon Monoxide Poisoning ◽  
Potential Benefits ◽  
Nitric Oxide Inhibitors

Role of Carbon Monoxide and Nitric Oxide in Newborn Infants With Postasphyxial Hypoxic-Ischemic Encephalopathy

PEDIATRICS ◽  
2000 ◽  
Vol 106 (6) ◽  
pp. 1447-1451 ◽  
Author(s):  
Y. Shi ◽  
F. Pan ◽  
H. Li ◽  
J. Pan ◽  
S. Qin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Newborn Infants ◽  
Hypoxic Ischemic Encephalopathy ◽  
Ischemic Encephalopathy
Sign in / Sign up

Export Citation Format

Share Document