Natural Products as Treatments for and Leads to Active Compounds in Viral Diseases

2011 ◽  
pp. 167-186
Author(s):  
David Newman ◽  
Gordon Cragg
Keyword(s):  
Natural Products ◽  
Viral Diseases ◽  
Active Compounds

Ligand Fishing with Cellular Membrane-Coated Magnetic Beads: A New Method for the Screening of Potentially Active Compounds from Natural Products

2017 ◽  
Vol 80 (10) ◽  
pp. 1517-1525 ◽  
Author(s):  
Cheng Tang ◽  
Ruizhi Mao ◽  
Fang Liu ◽  
Yaming Yu ◽  
Liang Xu ◽  
...  
Keyword(s):  
Natural Products ◽  
Magnetic Beads ◽  
Cellular Membrane ◽  
New Method ◽  
Active Compounds ◽  
Ligand Fishing

scholarly journals Computational Approaches for the Discovery and Development of Pharmacologically Active Natural Products

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 630
Author(s):  
José L. Medina-Franco
Keyword(s):  
Natural Products ◽  
Significant Source ◽  
Active Compounds ◽  
Computational Approaches ◽  
Pharmacologically Active ◽  
Active Natural

Natural products continue to be a significant source of active compounds [...]

Novel Cell Membrane Capillary Chromatography for Screening Active Compounds from Natural Products

2013 ◽  
Vol 76 (11-12) ◽  
pp. 697-701 ◽  
Author(s):  
Cheng Tang ◽  
Zhao-Sheng Liu ◽  
Nan Qin ◽  
Liang Xu ◽  
Hong-Quan Duan
Keyword(s):  
Natural Products ◽  
Cell Membrane ◽  
Capillary Chromatography ◽  
Active Compounds

The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control

Planta Medica ◽  
2020 ◽  
Author(s):  
Marilia Valli ◽  
Letícia Cristina Vieira Atanázio ◽  
Gustavo Claro Monteiro ◽  
Roberta Ramos Coelho ◽  
Daniel Pecoraro Demarque ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Vector Control ◽  
Plant Species ◽  
Mosquito Control ◽  
Biologically Active ◽  
Molecular Models ◽  
Public Health Importance ◽  
Active Compounds ◽  
Brazilian Biodiversity

AbstractNatural products are a valuable source of biologically active compounds and continue to play an important role in modern drug discovery due to their great structural diversity and unique biological properties. Brazilian biodiversity is one of the most extensive in the world and could be an effective source of new chemical entities for drug discovery. Mosquitoes are vectors for the transmission of dengue, Zika, chikungunya, yellow fever, and many other diseases of public health importance. These diseases have a major impact on tropical and subtropical countries, and their incidence has increased dramatically in recent decades, reaching billions of people at risk worldwide. The prevention of these diseases is mainly through vector control, which is becoming more difficult because of the emergence of resistant mosquito populations to the chemical insecticides. Strategies to provide efficient and safe vector control are needed, and secondary metabolites from plant species from the Brazilian biodiversity, especially Cerrado, that are biologically active for mosquito control are herein highlighted. Also, this is a literature revision of targets as insights to promote advances in the task of developing active compounds for vector control. In view of the expansion and occurrence of arboviruses diseases worldwide, scientific reviews on bioactive natural products are important to provide molecular models for vector control and contribute with effective measures to reduce their incidence.

scholarly journals Solvent Derived Artifacts in Natural Products Chemistry

2009 ◽  
Vol 4 (3) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Federica Maltese ◽  
Frank van der Kooy ◽  
Robert Verpoorte
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Chemical Reactions ◽  
Critical Role ◽  
Total Yield ◽  
Purification Method ◽  
Active Compounds ◽  
Natural Product Chemistry ◽  
Extraction And Purification ◽  
Product Chemistry

Solvents play an important and critical role in natural product chemistry. They are mainly used during the extraction and purification of metabolites from a biological matrix. To a lesser extent, solvents are also used as reagents or catalysts to perform chemical reactions. This review focuses on the most important classes of solvents, including alcohols, halogen-containing solvents, esters, ethers, acids and bases. The chemical reactions associated with the use of these solvents to form the so-called “artifacts” are discussed and the most common contaminants found in these solvents are also reviewed. The formation of artifacts and the use of contaminated solvents mainly leads to the formation of new compounds, loss of activity of active compounds, formation of active compounds from inactive ones (false positives), loss in total yield of important compounds during isolation, formation of toxic compounds and difficulty in reproducing an extraction or purification method. Finally, the need for stability studies of purified natural products is emphasized, as this is a common overlooked aspect in natural product chemistry.

scholarly journals Analysis of Bovine Serum Albumin Ligands fromPuerariae flosUsing Ultrafiltration Combined with HPLC-MS

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Ping Tang ◽  
Shihui Si ◽  
Liangliang Liu
Keyword(s):  
Natural Products ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
High Performance ◽  
Rapid Screening ◽  
Active Compounds ◽  
Fundamental Parameters ◽  
Isolation Techniques ◽  
Puerariae Flos

Rapid screening techniques for identification of active compounds from natural products are important not only for clarification of the therapeutic material basis, but also for supplying suitable chemical markers for quality control. In the present study, ultrafiltration combined with high performance liquid chromatography-mass spectrometry (HPLC-MS) was developed and conducted to screen and identify bovine serum albumin (BSA) bound ligands fromPuerariae flos. Fundamental parameters affecting the screening like incubation time, BSA concentration, pH, and temperature were studied and optimized. Under the optimum conditions, nine active compounds were identified by UV and MS data. The results indicated that this method was able to screen and identify BSA bound ligands form natural products without the need of preparative isolation techniques. Moreover, the method has more effective with easier operation procedures.

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