Polymers for Biomedical Applications: Chemical Modification and Biofunctionalization

2011 ◽  
pp. 43-66
Keyword(s):  
Chemical Modification ◽  
Biomedical Applications

Chemical modification of enveloped viruses for biomedical applications

2018 ◽  
Vol 10 (11) ◽  
pp. 666-679 ◽  
Author(s):  
Pahweenvaj Ratnatilaka Na Bhuket ◽  
Jittima Amie Luckanagul ◽  
Pornchai Rojsitthisak ◽  
Qian Wang
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Biomedical Applications ◽  
Vaccine Development ◽  
Enveloped Viruses ◽  
Bio Imaging

Chemistry enables scientists to use enveloped viruses in several biomedical applications including bio-imaging, drug delivery and vaccine development.

scholarly journals Mild Covalent Functionalization of Transition Metal Dichalcogenides with Maleimides: A “Click” Reaction for TMDCs

2018 ◽  
Author(s):  
Mariano Vera-Hidalgo ◽  
Emerson Giovanelli ◽  
Cristina Navío ◽  
Emilio Pérez
Keyword(s):  
Transition Metal ◽  
Chemical Modification ◽  
Biomedical Applications ◽  
Click Reaction ◽  
Transition Metal Dichalcogenides ◽  
Polymer Chemistry ◽  
Covalent Functionalization ◽  
Click Reactions ◽  
Mild Conditions ◽  
Metal Dichalcogenides

The physical properties of ultrathin transition metal dichalcogenides (2D-TMDCs) make them promising candidates as active nanomaterials for catalysis, optoelectronics, and biomedical applications. Chemical modification of TMDCs is expected to be key in modifying/adding new functions that will help make such promise a reality. We present a mild method for the modification of the basal planes of 2H-MoS<sub>2</sub> and WS<sub>2</sub>. We exploit the soft nucleophilicity of sulfur to react it with maleimide derivatives, achieving covalent functionalization of 2H-TMDCs under very mild conditions. Extensive characterization proves that the reaction occurs through Michael addition. Our results adapt one of the most popular “click” reactions in polymer chemistry and biochemistry to obtain a powerful tool for the chemical manipulation of TMDCs.

Ionic liquids in the processing and chemical modification of chitin and chitosan for biomedical applications

2017 ◽  
Vol 19 (5) ◽  
pp. 1208-1220 ◽  
Author(s):  
Simone S. Silva ◽  
João F. Mano ◽  
Rui L. Reis
Keyword(s):  
Ionic Liquids ◽  
Chemical Modification ◽  
Biomedical Applications ◽  
Chitin And Chitosan

Ionic liquids (ILs) have huge potential to provide new ways for the sustainable processing of chitin and chitosan to a variety of matrices for biomedical applications

scholarly journals Synergistically complexation of phenol functionalized polymer induced in-situ microfiber formation for 3D printing of marine-based hydrogel

2022 ◽  
Author(s):  
Hafez Jafari ◽  
Christine Delporte ◽  
Katrien V. Bernaerts ◽  
Houman Alimoradi ◽  
Lei Nie ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Chemical Modification ◽  
Biomedical Applications ◽  
Safe Approach

The design of 3D printable bio-based hydrogels with enhanced mechanical properties and minimal chemical modification can open new opportunities in the field of biomedical applications. A facile and safe approach...

scholarly journals Cytocompatibility of Modified Silk Fibroin with Glycidyl Methacrylate for Tissue Engineering and Biomedical Applications

Biomolecules ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 35
Author(s):  
Heesun Hong ◽  
Ok Joo Lee ◽  
Young Jin Lee ◽  
Ji Seung Lee ◽  
Olatunji Ajiteru ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Chemical Modification ◽  
Silk Fibroin ◽  
Glycidyl Methacrylate ◽  
Biomedical Applications ◽  
Biological Assessment ◽  
Biological Damage ◽  
Encapsulated Cells ◽  
Chemical Residues ◽  
Β Sheet

Hydrogel with chemical modification has been used for 3D printing in the biomedical field of cell and tissue-based regeneration because it provides a good cellular microenvironment and mechanical supportive ability. As a scaffold and a matrix, hydrogel itself has to be modified chemically and physically to form a β-sheet crosslinking structure for the strength of the biomaterials. These chemical modifications could affect the biological damage done to encapsulated cells or surrounding tissues due to unreacted chemical residues. Biological assessment, including assessment of the cytocompatibility of hydrogel in clinical trials, must involve testing with cytotoxicity, irritation, and sensitization. Here, we modified silk fibroin and glycidyl methacrylate (Silk-GMA) and evaluated the physical characterizations, residual chemical detection, and the biological effect of residual GMA depending on dialysis periods. Silk-GMA depending on each dialysis period had a typical β-sheet structure in the characterization analysis and residual GMA decreased from dialysis day 1. Moreover, cell proliferation and viability rate gradually increased; additionally, necrotic and apoptotic cells decreased from dialysis day 2. These results indicate that the dialysis periods during chemical modification of natural polymer are important for removing unreacted chemical residues and for the potential application of the manufacturing standardization for chemically modified hydrogel for the clinical transplantation for tissue engineering and biomedical applications.

scholarly journals Marine Derived Polysaccharides for Biomedical Applications: Chemical Modification Approaches

Molecules ◽  
2008 ◽  
Vol 13 (9) ◽  
pp. 2069-2106 ◽  
Author(s):  
Giovanna D’Ayala ◽  
Mario Malinconico ◽  
Paola Laurienzo
Keyword(s):  
Chemical Modification ◽  
Biomedical Applications

scholarly journals Boronic acid recognition of non-interacting carbohydrates for biomedical applications: increasing fluorescence signals of minimally interacting aldoses and sucralose

2017 ◽  
Vol 15 (45) ◽  
pp. 9727-9733 ◽  
Author(s):  
Angel Resendez ◽  
Md Abdul Halim ◽  
Jasmeet Singh ◽  
Dominic-Luc Webb ◽  
Bakthan Singaram
Keyword(s):  
Chemical Modification ◽  
Boronic Acid ◽  
Biomedical Applications ◽  
Binding Affinities ◽  
Detection Systems

To address carbohydrates that are commonly used in biomedical applications with low binding affinities for boronic acid based detection systems, two chemical modification methods were utilized to increase sensitivity.

scholarly journals Virus-Incorporated Biomimetic Nanocomposites for Tissue Regeneration

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 1014 ◽  
Author(s):  
Iruthayapandi Selestin Raja ◽  
Chuntae Kim ◽  
Su-Jin Song ◽  
Yong Cheol Shin ◽  
Moon Sung Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Phage Display ◽  
Tissue Regeneration ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Future Directions ◽  
Biomimetic Materials ◽  
Peptide Expression

Owing to the astonishing properties of non-harmful viruses, tissue regeneration using virus-based biomimetic materials has been an emerging trend recently. The selective peptide expression and enrichment of the desired peptide on the surface, monodispersion, self-assembly, and ease of genetic and chemical modification properties have allowed viruses to take a long stride in biomedical applications. Researchers have published many reviews so far describing unusual properties of virus-based nanoparticles, phage display, modification, and possible biomedical applications, including biosensors, bioimaging, tissue regeneration, and drug delivery, however the integration of the virus into different biomaterials for the application of tissue regeneration is not yet discussed in detail. This review will focus on various morphologies of virus-incorporated biomimetic nanocomposites in tissue regeneration and highlight the progress, challenges, and future directions in this area.

Functional Chitosan-based Materials for Biological Applications

2020 ◽  
Vol 27 (28) ◽  
pp. 4660-4672 ◽  
Author(s):  
Jiliang Ma ◽  
Linxin Zhong ◽  
Xinwen Peng ◽  
Yongkang Xu ◽  
Runcang Sun
Keyword(s):  
Chemical Modification ◽  
Renewable Resources ◽  
Biomedical Applications ◽  
Research Literature ◽  
Biological Applications ◽  
Naturally Occurring ◽  
Excellent Activity ◽  
Potential Applications ◽  
Important Field ◽  
The Ideal

Background: Bio-based materials, as the plentiful and renewable resources for natural constituents which are essential for biomedical and pharmaceutical applications, have not been exploited adequately yet. Chitosan is a naturally occurring polysaccharide obtained from chitin, which has recently attracted widespread attention owing to its excellent activity. This review shows the methods of extraction and modification of chitosan and provides recent progress of synthesis and use of chitosan-based materials in biological applications. Methods: By consulting the research literature of the last decade, the recent progresses of functional chitosan-based materials for biological applications were summarized and divided into the methods of extraction chitosan, the chemical modification of chitosan, chitosan-based materials for biological applications were described and discussed. Results: Chemical modification of chitosan broadens its applications, leading to developing numerous forms of chitosan-based materials with excellent properties. The excellent bioactivity of chitosan-based material enables it serves potential applications in biomedical fields. Conclusion: Chitosan-based materials not only exhibit the excellent activities of chitosan but also show other appealing performance of combined materials, even give the good synergistic properties of chitosan and its composite materials. Further studies are needed to define the ideal physicochemical properties of chitosan for each type of biomedical applications. The development of various functional chitosan-based materials for biological applications will be an important field of research, and this kind of material has important commercial value.

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