Chemical modification of enveloped viruses for biomedical applications

2018 ◽  
Vol 10 (11) ◽  
pp. 666-679 ◽  
Author(s):  
Pahweenvaj Ratnatilaka Na Bhuket ◽  
Jittima Amie Luckanagul ◽  
Pornchai Rojsitthisak ◽  
Qian Wang
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Biomedical Applications ◽  
Vaccine Development ◽  
Enveloped Viruses ◽  
Bio Imaging

Chemistry enables scientists to use enveloped viruses in several biomedical applications including bio-imaging, drug delivery and vaccine development.

scholarly journals Stimuli-responsive nanobubbles for biomedical applications

2021 ◽  
Author(s):  
Ranhua Xiong ◽  
Ronald X. Xu ◽  
Chaobo Huang ◽  
Stefaan De Smedt ◽  
Kevin Braeckmans
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Recent Advances ◽  
Tumor Tissues ◽  
Bio Imaging

This review presents an overview of the recent advances in the development of stimuli-responsive nanobubbles and their novel biomedical applications including bio-imaging, drug delivery and ablation of tumor tissues.

scholarly journals Nanotechnology and Biomedical Applications of Nanotechnology

2021 ◽  
pp. 9-17
Author(s):  
Khyati D. Kshirsagar ◽  
Shubham M. Avhad ◽  
Pracheta A. Kuwar
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Colloidal Particles ◽  
Metal Oxide Nanoparticles ◽  
Volume Ratio ◽  
Cell Labelling ◽  
Oxide Nanoparticles ◽  
Ablation Therapy ◽  
Bio Imaging ◽  
Enhanced Surface

Solid colloidal particles of size from 10 to 1000 Nanometre are known as Nanoparticles. Nanoparticles contribute many benefits to bigger particles such as enhanced surface-to-volume ratio and enhanced magnetic properties. Over the last few years, there has been an undeviating growing interest in using nanoparticles in different biomedical applications such as targeted drug delivery, hyperthermia, photo ablation therapy, bio imaging, and biosensors. Iron oxide nanoparticles have dominated applications, such as drug delivery, hyperthermia, bio imaging, cell labelling, and gene delivery, because of their superior properties such as chemical stability, non-toxicity, biocompatibility, high saturation magnetization, and high magnetic susceptibility. In this paper, biomedical applications of two different types of nanoparticles metal oxide nanoparticles and carbon nanotubes are discussed.

scholarly journals Virus-Incorporated Biomimetic Nanocomposites for Tissue Regeneration

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 1014 ◽  
Author(s):  
Iruthayapandi Selestin Raja ◽  
Chuntae Kim ◽  
Su-Jin Song ◽  
Yong Cheol Shin ◽  
Moon Sung Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chemical Modification ◽  
Phage Display ◽  
Tissue Regeneration ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Future Directions ◽  
Biomimetic Materials ◽  
Peptide Expression

Owing to the astonishing properties of non-harmful viruses, tissue regeneration using virus-based biomimetic materials has been an emerging trend recently. The selective peptide expression and enrichment of the desired peptide on the surface, monodispersion, self-assembly, and ease of genetic and chemical modification properties have allowed viruses to take a long stride in biomedical applications. Researchers have published many reviews so far describing unusual properties of virus-based nanoparticles, phage display, modification, and possible biomedical applications, including biosensors, bioimaging, tissue regeneration, and drug delivery, however the integration of the virus into different biomaterials for the application of tissue regeneration is not yet discussed in detail. This review will focus on various morphologies of virus-incorporated biomimetic nanocomposites in tissue regeneration and highlight the progress, challenges, and future directions in this area.

scholarly journals Development of biological metal–organic frameworks designed for biomedical applications: from bio-sensing/bio-imaging to disease treatment

2020 ◽  
Vol 2 (9) ◽  
pp. 3788-3797 ◽  
Author(s):  
Huai-Song Wang ◽  
Yi-Hui Wang ◽  
Ya Ding
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Metal Organic Frameworks ◽  
Disease Treatment ◽  
Metal Organic ◽  
Bio Imaging

This review introduces biological metal–organic frameworks (bio-MOFs) designed and prepared using biological ligands for bio-sensing, bio-imaging, and drug delivery.

scholarly journals Strategies to Obtain Designer Polymers Based on Cyanobacterial Extracellular Polymeric Substances (EPS)

2019 ◽  
Vol 20 (22) ◽  
pp. 5693 ◽  
Author(s):  
Sara B. Pereira ◽  
Aureliana Sousa ◽  
Marina Santos ◽  
Marco Araújo ◽  
Filipa Serôdio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Genetic Engineering ◽  
Chemical Modification ◽  
Biomedical Applications ◽  
Extracellular Polymeric Substances ◽  
Biological Activities ◽  
Environmentally Friendly ◽  
Biosynthetic Pathways ◽  
Central Metabolism ◽  
Challenges And Opportunities

Biopolymers derived from polysaccharides are a sustainable and environmentally friendly alternative to the synthetic counterparts available in the market. Due to their distinctive properties, the cyanobacterial extracellular polymeric substances (EPS), mainly composed of heteropolysaccharides, emerge as a valid alternative to address several biotechnological and biomedical challenges. Nevertheless, biotechnological/biomedical applications based on cyanobacterial EPS have only recently started to emerge. For the successful exploitation of cyanobacterial EPS, it is important to strategically design the polymers, either by genetic engineering of the producing strains or by chemical modification of the polymers. This requires a better understanding of the EPS biosynthetic pathways and their relationship with central metabolism, as well as to exploit the available polymer functionalization chemistries. Considering all this, we provide an overview of the characteristics and biological activities of cyanobacterial EPS, discuss the challenges and opportunities to improve the amount and/or characteristics of the polymers, and report the most relevant advances on the use of cyanobacterial EPS as scaffolds, coatings, and vehicles for drug delivery.

scholarly journals Inorganic–inorganic nanohybrids for drug delivery, imaging and photo-therapy: recent developments and future scope

2021 ◽  
Vol 12 (14) ◽  
pp. 5044-5063 ◽  
Author(s):  
Goeun Choi ◽  
N. Sanoj Rejinold ◽  
Huiyan Piao ◽  
Jin-Ho Choy
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Present Review ◽  
Recent Developments ◽  
Bio Imaging

The present review will be detailing about trending inorganic–inorganic nanohybrids that have been used for various biomedical applications including drug-delivery, bio-imaging and photo therapy.

Biocompatible Polymers and their Potential Biomedical Applications: A Review

2019 ◽  
Vol 25 (34) ◽  
pp. 3608-3619 ◽  
Author(s):  
Uzma Arif ◽  
Sajjad Haider ◽  
Adnan Haider ◽  
Naeem Khan ◽  
Abdulaziz A. Alghyamah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Biomedical Applications ◽  
Living System ◽  
Health Condition ◽  
The Body ◽  
Biocompatible Polymers ◽  
Nano Technology ◽  
Artificial Grafts ◽  
Immunological Reactions

Background: Biocompatible polymers are gaining great interest in the field of biomedical applications. The term biocompatibility refers to the suitability of a polymer to body and body fluids exposure. Biocompatible polymers are both synthetic (man-made) and natural and aid in the close vicinity of a living system or work in intimacy with living cells. These are used to gauge, treat, boost, or substitute any tissue, organ or function of the body. A biocompatible polymer improves body functions without altering its normal functioning and triggering allergies or other side effects. It encompasses advances in tissue culture, tissue scaffolds, implantation, artificial grafts, wound fabrication, controlled drug delivery, bone filler material, etc. Objectives: This review provides an insight into the remarkable contribution made by some well-known biopolymers such as polylactic-co-glycolic acid, poly(ε-caprolactone) (PCL), polyLactic Acid, poly(3- hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), Chitosan and Cellulose in the therapeutic measure for many biomedical applications. Methods: : Various techniques and methods have made biopolymers more significant in the biomedical fields such as augmentation (replaced petroleum based polymers), film processing, injection modeling, blow molding techniques, controlled / implantable drug delivery devices, biological grafting, nano technology, tissue engineering etc. Results: The fore mentioned techniques and other advanced techniques have resulted in improved biocompatibility, nontoxicity, renewability, mild processing conditions, health condition, reduced immunological reactions and minimized side effects that would occur if synthetic polymers are used in a host cell. Conclusion: Biopolymers have brought effective and attainable targets in pharmaceutics and therapeutics. There are huge numbers of biopolymers reported in the literature that has been used effectively and extensively.

Biomedical Applications of Natural Polymers for Drug Delivery

2014 ◽  
Vol 18 (2) ◽  
pp. 152-164 ◽  
Author(s):  
Mariana Chifiriuc ◽  
Alexandru Grumezescu ◽  
Valentina Grumezescu ◽  
Eugenia Bezirtzoglou ◽  
Veronica Lazar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Natural Polymers

Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications

2020 ◽  
Vol 21 ◽  
Author(s):  
Dickson Pius Wande ◽  
Qin Cui ◽  
Shijie Chen ◽  
Cheng Xu ◽  
Hui Xiong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Dissolution ◽  
Glycol Succinate ◽  
Permeation Enhancer ◽  
P Glycoprotein ◽  
Us Fda ◽  
Anticancer Compound

: As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

scholarly journals The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

2021 ◽  
Author(s):  
Marissa Morales-Moctezuma ◽  
Sebastian G Spain
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Biomedical Applications

Nanogels have emerged as innovative platforms for numerous biomedical applications including gene and drug delivery, biosensors, imaging, and tissue engineering. Polymerisation-induced thermal self-assembly (PITSA) has been shown to be suitable...

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