Bioactive Glass-Based Coatings and Modied Surfaces: Strategies for the Manufacture, Testing, and Clinical Applications for Regenerative Medicine

2011 ◽  
pp. 391-444
Keyword(s):  
Regenerative Medicine ◽  
Bioactive Glass ◽  
Clinical Applications

scholarly journals Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century

2015 ◽  
Vol 2015 ◽  
pp. 1-19 ◽  
Author(s):  
J.-F. Stoltz ◽  
N. de Isla ◽  
Y. P. Li ◽  
D. Bensoussan ◽  
L. Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Regenerative Medicine ◽  
Embryonic Stem ◽  
Clinical Applications ◽  
Cardiac Insufficiency ◽  
Immunomodulatory Activity ◽  
Hematopoietic Stem ◽  
Fetal Stem Cells ◽  
Organ Regeneration

Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been an increasing interest in the study of undifferentiated progenitors that have the ability to proliferate and differentiate into various tissues. Stem cells (SC) with different potency can be isolated and characterised. Despite the promise of embryonic stem cells, in many cases, adult or even fetal stem cells provide a more interesting approach for clinical applications. It is undeniable that mesenchymal stem cells (MSC) from bone marrow, adipose tissue, or Wharton’s Jelly are of potential interest for clinical applications in regenerative medicine because they are easily available without ethical problems for their uses. During the last 10 years, these multipotent cells have generated considerable interest and have particularly been shown to escape to allogeneic immune response and be capable of immunomodulatory activity. These properties may be of a great interest for regenerative medicine. Different clinical applications are under study (cardiac insufficiency, atherosclerosis, stroke, bone and cartilage deterioration, diabetes, urology, liver, ophthalmology, and organ’s reconstruction). This review focuses mainly on tissue and organ regeneration using SC and in particular MSC.

Regenerative medicine: clinical applications of stem cells

Stem Cells ◽  
2021 ◽  
pp. 159-220
Author(s):  
Christine L. Mummery ◽  
Anja van de Stolpe ◽  
Bernard Roelen ◽  
Hans Clevers
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Clinical Applications

scholarly journals Autologous Materials in Regenerative Dentistry: Harvested Bone, Platelet Concentrates and Dentin Derivates

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5330
Author(s):  
Sara Bernardi ◽  
Guido Macchiarelli ◽  
Serena Bianchi
Keyword(s):  
Regenerative Medicine ◽  
Bone Tissue ◽  
Clinical Applications ◽  
Physiological Characteristics ◽  
Sinus Lift ◽  
Platelet Concentrates ◽  
Specific Group ◽  
Ridge Augmentation ◽  
Regenerative Dentistry

The jawbone is a peculiar type of bone tissue, unique for its histological, anatomical and physiological characteristics. Therefore, a defect in the maxilla or in the mandible, because of pathological sequelae is difficult to prevent and to restore. Several biomaterials have been and are currently being developed to respond to the demands of regenerative medicine. A specific group of biomaterials used in regenerative dentistry is represented by the autologous materials. Platelet concentrates harvested bone and dentin derivates are indeed used in an attempt to minimise the alveolar resorption or in vertical ridge augmentation procedures or in sinus lift interventions. The aim of this review is to examine the properties of the above-listed materials, to compare them and to indicate eventual clinical applications.

Regenerative Medicine: Clinical Applications of Stem Cells

Stem Cells ◽  
2011 ◽  
pp. 133-195
Author(s):  
Christine Mummery ◽  
Sir Ian Wilmut ◽  
Anja van de Stolpe ◽  
Bernard A.J. Roelen
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Clinical Applications

scholarly journals Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review

2018 ◽  
Vol 18 (3) ◽  
pp. 264 ◽  
Author(s):  
Roberto Berebichez-Fridman ◽  
Pablo R. Montero-Olvera
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Adult Stem Cells ◽  
Current Knowledge ◽  
Clinical Applications ◽  
The Body ◽  
Differentiation Potential ◽  
Advantages And Disadvantages

First discovered by Friedenstein in 1976, mesenchymal stem cells (MSCs) are adult stem cells found throughout the body that share a fixed set of characteristics. Discovered initially in the bone marrow, this cell source is considered the gold standard for clinical research, although various other sources—including adipose tissue, dental pulp, mobilised peripheral blood and birth-derived tissues—have since been identified. Although similar, MSCs derived from different sources possess distinct characteristics, advantages and disadvantages, including their differentiation potential and proliferation capacity, which influence their applicability. Hence, they may be used for specific clinical applications in the fields of regenerative medicine and tissue engineering. This review article summarises current knowledge regarding the various sources, characteristics and therapeutic applications of MSCs.Keywords: Mesenchymal Stem Cells; Adult Stem Cells; Regenerative Medicine; Cell Differentiation; Tissue Engineering.

Stem cells of the skin and cornea: their clinical applications in regenerative medicine

2011 ◽  
Vol 16 (1) ◽  
pp. 87-89 ◽  
Author(s):  
Stéphanie Proulx ◽  
Julie Fradette ◽  
Robert Gauvin ◽  
Danielle Larouche ◽  
Lucie Germain
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Clinical Applications

scholarly journals Valproic Acid Promotes Early Neural Differentiation in Adult Mesenchymal Stem Cells Through Protein Signalling Pathways

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 619 ◽  
Author(s):  
Jerran Santos ◽  
Thibaut Hubert ◽  
Bruce K Milthorpe
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Neural Differentiation ◽  
Clinical Applications ◽  
Janus Kinase ◽  
Fibroblast Growth Factor 21 ◽  
Neural Cells ◽  
Adult Mesenchymal Stem Cells

Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell types applicable for regenerative medicine (specifically neural cells, using chemicals). Valproic acid was an ideal candidate due to its clinical stability. It has been implicated in the induction of neural differentiation; however, the mechanism and the downstream events were not known. In this study, we showed that using valproic acid on adult mesenchymal stem cells induced neural differentiation within 24 h by upregulating the expression of suppressor of cytokine signaling 5 (SOCS5) and Fibroblast growth factor 21 (FGF21), without increasing the potential death rate of the cells. Through this, the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is downregulated, and the mitogen-activated protein kinase (MAPK) cascade is activated. The bioinformatics analyses revealed the expression of several neuro-specific proteins as well as a range of functional and structural proteins involved in the formation and development of the neural cells.

scholarly journals Applications of 3D Bioprinting in Tissue Engineering and Regenerative Medicine

2021 ◽  
Vol 10 (21) ◽  
pp. 4966
Author(s):  
Gia Saini ◽  
Nicole Segaran ◽  
Joseph L. Mayer ◽  
Aman Saini ◽  
Hassan Albadawi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Living Cells ◽  
Clinical Applications ◽  
3D Bioprinting ◽  
Future Directions ◽  
Specialized Tissue ◽  
Tissue Models ◽  
Functional Components

Regenerative medicine is an emerging field that centers on the restoration and regeneration of functional components of damaged tissue. Tissue engineering is an application of regenerative medicine and seeks to create functional tissue components and whole organs. Using 3D printing technologies, native tissue mimics can be created utilizing biomaterials and living cells. Recently, regenerative medicine has begun to employ 3D bioprinting methods to create highly specialized tissue models to improve upon conventional tissue engineering methods. Here, we review the use of 3D bioprinting in the advancement of tissue engineering by describing the process of 3D bioprinting and its advantages over other tissue engineering methods. Materials and techniques in bioprinting are also reviewed, in addition to future clinical applications, challenges, and future directions of the field.

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