Analysis of Residual Solvents by Head Space Gas Chromatography

2011 ◽  
pp. 345-364
Keyword(s):  
Gas Chromatography ◽  
Residual Solvents ◽  
Head Space ◽  
Head Space Gas Chromatography

scholarly journals Residual solvent determination by head space gas chromatography with flame ionization detector in omeprazole API

2011 ◽  
Vol 47 (2) ◽  
pp. 379-384 ◽  
Author(s):  
Saurabh Pandey ◽  
Preeti Pandey ◽  
Raj Kumar ◽  
Narendra Pal Singh
Keyword(s):  
Gas Chromatography ◽  
Active Pharmaceutical Ingredient ◽  
Reversible Inhibitor ◽  
Internal Diameter ◽  
Residual Solvent ◽  
Residual Solvents ◽  
Pharmaceutical Ingredients ◽  
Flame Ionization ◽  
Head Space ◽  
Head Space Gas Chromatography

Residual solvents in pharmaceutical samples are monitored using gas chromatography with head space. Based on good manufacturing practices, measuring residual solvents is mandatory for the release testing of all active pharmaceutical ingredients (API). The analysis of residual organic solvents (methanol, acetone, cyclohexane, dichloromethane, toluene) in Omeprazole, an active pharmaceutical ingredient was investigated. Omeprazole is a potent reversible inhibitor of the gastric proton pump H+/K+-ATPase. The Head space gas chromatography (HSGC) method described in this investigation utilized a SPB TM-624, Supelco, 30 m long x 0.25 mm internal diameter, 1.4µm-thick column. Since Omeprazole is a thermally labile compound, the selection of the proper injector temperature is critical to the success of the analysis. The injector temperature was set at 170ºC to prevent degradation. The initial oven temperature was set at 40ºC for 12 min and programmed at a rate of 10ºC min-1 to a final temperature of 220ºC for 5 min. Nitrogen was used as a carrier gas. The sample solvent selected was N,N-dimethylacetamide. The method was validated to be specific, linear, precise, sensitive, rugged and showed excellent recovery.

scholarly journals Analysis of Residual Solvents in Flavor Preparations by Head-Space Gas Chromatography

1997 ◽  
Vol 38 (2) ◽  
pp. 97-104_1 ◽  
Author(s):  
Yoko UEMATSU ◽  
Yuki SADAMASU ◽  
Keiko HIRATA ◽  
Masako HIROKADO ◽  
Kazuo YASUDA ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Residual Solvents ◽  
Head Space ◽  
Head Space Gas Chromatography

Effect Of Water On Head Space-Gas Chromatography Odorants Signals From Orange Juice: A Possible Influence On Odor Intensity

LWT ◽  
2021 ◽  
pp. 111712
Author(s):  
David Reznik ◽  
Aviv Kaplan ◽  
Igal Gozlan ◽  
Gefen Ronen-Eliraz ◽  
Dror Avisar
Keyword(s):  
Gas Chromatography ◽  
Orange Juice ◽  
Odor Intensity ◽  
Effect Of Water ◽  
Head Space ◽  
Head Space Gas Chromatography
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