▪ Multiscale Modeling of Cell Motion in Three- Dimensional Environments

2010 ◽  
pp. 182-197
Keyword(s):  
Multiscale Modeling ◽  
Three Dimensional ◽  
Cell Motion

Understanding the mechanical link between oriented cell division and cerebellar morphogenesis

Soft Matter ◽  
2019 ◽  
Vol 15 (10) ◽  
pp. 2204-2215 ◽  
Author(s):  
Emma Lejeune ◽  
Berkin Dortdivanlioglu ◽  
Ellen Kuhl ◽  
Christian Linder
Keyword(s):  
Cell Division ◽  
Multiscale Modeling ◽  
Three Dimensional ◽  
Mechanical Instability ◽  
Oriented Cell Division ◽  
Cerebellar Morphogenesis

Three-dimensional multiscale modeling shows that oriented cell division leads to a mechanical instability that can initiate cerebellar foliation.

Multiscale Modeling of the Three-Dimensional Meniscus Shape of a Wetting Liquid Film on Micro-/Nanostructured Surfaces

Langmuir ◽  
2017 ◽  
Vol 33 (43) ◽  
pp. 12028-12037 ◽  
Author(s):  
Han Hu ◽  
Monojit Chakraborty ◽  
Taylor P. Allred ◽  
Justin A. Weibel ◽  
Suresh V. Garimella
Keyword(s):  
Liquid Film ◽  
Multiscale Modeling ◽  
Three Dimensional ◽  
Nanostructured Surfaces ◽  
Meniscus Shape ◽  
Wetting Liquid

A Coupled Computational Framework for Multiscale Modeling and Optimization of Single Ventricle Repair

2011 ◽  
Author(s):  
Alison L. Marsden ◽  
Mahdi Esmaily Moghadam ◽  
Weiguang Yang ◽  
Alessia Baretta ◽  
Chiara Corsini ◽  
...  
Keyword(s):  
Multiscale Modeling ◽  
Single Ventricle ◽  
Three Dimensional ◽  
Circulatory System ◽  
Neumann Boundary ◽  
Dimensional Finite Element ◽  
Fontan Surgery ◽  
Three Dimensional Finite Element ◽  
Stage 1 ◽  
Two Stages

Multiscale modeling provides a means to relate global response to local changes in geometry and hemodynamics in the circulatory system. In this work, we couple a customized lumped parameter network (LPN) representing the whole circulation (heart, systemic and pulmonary circulations) to three-dimensional finite element models of two stages of the single ventricle surgical pathway. A fully-coupled closed-loop approach is employed using custom codes with Neumann boundary conditions at the inlets and outlets. The methodology is described, and applied to two stages of single ventricle repair to illustrate its utility: the BT-shunt (stage 1), and the Fontan surgery (stage 3).

Pseudo-three-dimensional convective cell motion in a magnetized plasma

1984 ◽  
Vol 31 (2) ◽  
pp. 231-238 ◽  
Author(s):  
P. K. Shukla ◽  
M. Y. Yu
Keyword(s):  
Magnetic Field ◽  
External Magnetic Field ◽  
Mode Coupling ◽  
Three Dimensional ◽  
Convective Cell ◽  
Magnetized Plasma ◽  
Space Plasmas ◽  
Linear And Nonlinear ◽  
Convective Cells ◽  
Cell Motion

Linear and nonlinear mechanisms for generating convective cells with finite but small parallel (to the external magnetic field B0) wavelength are presented. The problems of mode-coupling as well as quasi-steady nonlinear mode structures are analytically studied. Possible applications in space plasmas are discussed.

scholarly journals A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels

2020 ◽  
Vol 16 (4) ◽  
pp. e1007709
Author(s):  
Xiaoning Zheng ◽  
Alireza Yazdani ◽  
He Li ◽  
Jay D. Humphrey ◽  
George E. Karniadakis
Keyword(s):  
Blood Vessels ◽  
Multiscale Modeling ◽  
Phase Field ◽  
Field Model ◽  
Three Dimensional ◽  
Phase Field Model

scholarly journals Three-Dimensional Multiscale Modeling of Dendritic Spacing Selection During Al-Si Directional Solidification

JOM ◽  
2015 ◽  
Vol 67 (8) ◽  
pp. 1776-1785 ◽  
Author(s):  
Damien Tourret ◽  
Amy J. Clarke ◽  
Seth D. Imhoff ◽  
Paul J. Gibbs ◽  
John W. Gibbs ◽  
...  
Keyword(s):  
Directional Solidification ◽  
Multiscale Modeling ◽  
Three Dimensional ◽  
Dendritic Spacing ◽  
Spacing Selection

3D Computational Modeling and Simulation of Cell Motion on Adhesive Surfaces in Shear Flow

2008 ◽  
Author(s):  
Vijay Pappu ◽  
Prosenjit Bagchi
Keyword(s):  
Shear Flow ◽  
Fluid Dynamic ◽  
Three Dimensional ◽  
Cell Deformation ◽  
Immersed Boundary ◽  
Biophysical Parameters ◽  
Ligand Interaction ◽  
Computational Modeling And Simulation ◽  
Cell Motion ◽  
Transient Rolling

A three-dimensional computational fluid dynamic (CFD) model is presented to simulate transient rolling adhesion and deformation of leukocytes over a P-selectin coated surface in shear flow. The computational model is based on immersed boundary method for cell deformation, and stochastic Monte Carlo simulation for receptor/ligand interaction. The model is shown to predict the characteristic ‘stop-and-go’ motion of rolling leukocytes. The objective here is to understand the coupling between external shear flow, cell deformation, microvilli deformation and various biophysical parameters that govern the formation of selectin bonds. We observe that compliant cells roll more stably with lesser fluctuations. Adhesion is seen to occur via multiple tethers, but often one tether is sufficient to support rolling. The force loading on individual microvillus is not continuous, rather occurs in steps. Further, it is also shown that only the microvilli whose undeformed length is above a certain cut off length, participate in bond formation and the cutoff length reduces with increasing cell rigidity.

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