A New Catalytic Process Approach for Low Aromatic LCO

2010 ◽  
pp. 23-35
Author(s):  
William Gilbert ◽  
Edisson Morgado ◽  
Marco Abreu
Keyword(s):  
Process Approach ◽  
Catalytic Process

Crystal structures of Magnaporthe oryzae trehalose-6-phosphate synthase (MoTps1) suggest a model for catalytic process of Tps1

2019 ◽  
Vol 476 (21) ◽  
pp. 3227-3240 ◽  
Author(s):  
Shanshan Wang ◽  
Yanxiang Zhao ◽  
Long Yi ◽  
Minghe Shen ◽  
Chao Wang ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Conformational Changes ◽  
Magnaporthe Oryzae ◽  
Structural Information ◽  
Complex Structure ◽  
Critical Role ◽  
Catalytic Process ◽  
Structural Basis ◽  
Salt Bridges ◽  
Terminal Domain

Trehalose-6-phosphate (T6P) synthase (Tps1) catalyzes the formation of T6P from UDP-glucose (UDPG) (or GDPG, etc.) and glucose-6-phosphate (G6P), and structural basis of this process has not been well studied. MoTps1 (Magnaporthe oryzae Tps1) plays a critical role in carbon and nitrogen metabolism, but its structural information is unknown. Here we present the crystal structures of MoTps1 apo, binary (with UDPG) and ternary (with UDPG/G6P or UDP/T6P) complexes. MoTps1 consists of two modified Rossmann-fold domains and a catalytic center in-between. Unlike Escherichia coli OtsA (EcOtsA, the Tps1 of E. coli), MoTps1 exists as a mixture of monomer, dimer, and oligomer in solution. Inter-chain salt bridges, which are not fully conserved in EcOtsA, play primary roles in MoTps1 oligomerization. Binding of UDPG by MoTps1 C-terminal domain modifies the substrate pocket of MoTps1. In the MoTps1 ternary complex structure, UDP and T6P, the products of UDPG and G6P, are detected, and substantial conformational rearrangements of N-terminal domain, including structural reshuffling (β3–β4 loop to α0 helix) and movement of a ‘shift region' towards the catalytic centre, are observed. These conformational changes render MoTps1 to a ‘closed' state compared with its ‘open' state in apo or UDPG complex structures. By solving the EcOtsA apo structure, we confirmed that similar ligand binding induced conformational changes also exist in EcOtsA, although no structural reshuffling involved. Based on our research and previous studies, we present a model for the catalytic process of Tps1. Our research provides novel information on MoTps1, Tps1 family, and structure-based antifungal drug design.

Perspectives: A Process Approach to Social Communication for Adolescents With Asperger's Syndrome Using Radio Interviewing

2011 ◽  
Vol 12 (4) ◽  
pp. 110-120
Author(s):  
Amy Thrasher ◽  
Jennifer Wilger ◽  
Matthew Goldman ◽  
Catharine Whitlatch
Keyword(s):  
Social Communication ◽  
Social Skill ◽  
Asperger's Syndrome ◽  
Asperger’S Syndrome ◽  
Process Approach ◽  
Communication Intervention ◽  
Social Thinking ◽  
Social Communication Intervention

Abstract The Perspectives program is a unique collaborative social communication intervention for adolescents with Asperger's syndrome and similar learning profiles. Clinicians use radio interviews as the vehicle to explicitly teach the process of social communication. Social skill objectives are addressed through this process approach, which was adapted from the framework of Social Thinking (Winner, 2002)

Turbulence of Economic Processes: Theoretical Aspects

2009 ◽  
pp. 90-97 ◽  
Author(s):  
V. Burlachkov
Keyword(s):  
Economic System ◽  
Process Approach ◽  
Lorentz Transformations ◽  
Macroeconomic Dynamics ◽  
Turbulence Analysis

The article discusses turbulence of economic processes as a result of relative velocities of economic system elements. It is underlined that turbulence is the property of macroeconomic dynamics. The main reason of turbulence in economic system is the discrepancy between the velocity of deals contracting and the velocity of obligations executing. The process approach to the analysis of economic system as a set of processes is proposed. Using Lorentz transformations for turbulence analysis is discussed.

IMPLEMENTASI KURIKULUM BERBASIS INDUSTRI DI SMK MITRA INDUSTRI MM2100 CIKARANG - BEKASI

2020 ◽  
Vol 8 (2) ◽  
pp. 81-88
Author(s):  
Bambang Nurcahyono ◽  
Rita Retnowati ◽  
Entis Sutisna
Keyword(s):  
Curriculum Development ◽  
Learning Process ◽  
Qualitative Method ◽  
Process Approach ◽  
Development Model ◽  
Field Observations ◽  
Work Patterns ◽  
Block System ◽  
Comprehensive Picture ◽  
Dual Base

INDUSTRIAL BASED CURRICULUM IMPLEMETATION AT SMK MITRA INDUSTRI MM2100 CIKARANG-BEKASIThis study aims to obtain a fact-based picture in the form of data and information regarding the implementation of an industry-based curriculum at SMK Mitra Industri MM2100. This study uses a qualitative method, which is to make a complex and comprehensive picture with detailed descriptions from the eyes of the informants to produce a comprehensive exposure based on clear and real findings, events, processes and results related to the implementation of an industry-based curriculum. Data obtained through interviews, field observations and documentation studies. Based on data analysis, the following results are obtained: 1). The curriculum development model used at SMK Mitra Industri MM2100, is a model of curriculum development that is problem-centered by integrating several disciplines to form a concept of attitudes, skills and knowledge in accordance with the demands and needs of the industry which are oriented to the vision, mission and goals of the school. 2). The learning process at SMK Mitra Industri MM2100 uses a block system, which is designed to be oriented towards the merging of instruction and construction, so that the learning process approach refers to the dual base program to fully and fully cultivate industrial work patterns. 3). Challenges and obstacles in the implementation of industrial-based curriculum in SMK Mitra Industri MM2100 in the form of not wanting to change the principles of school/mental blockage, focusing on knowledge, school target is focus on graduation of students, not on the distribution of work at industries and bad networking with industry which can be overcome through socialization to all elements of the school and stakeholders involved.

PROCESS APPROACH AND MODEL OF QUALITY MANAGEMENT EDUCATION NEW STANDARDS ISO

2015 ◽  
Vol 19 (95) ◽  
pp. 317-321
Author(s):  
Anna G. Oborskaya ◽  
◽  
Tatyana V. Otradskaya ◽  
Valentina Yu. Vasilieva ◽  
◽  
...  
Keyword(s):  
Quality Management ◽  
Management Education ◽  
Process Approach

Paradigma Pendidikan Kritis: Menuju Humanisasi Pendidikan

1970 ◽  
Vol 13 (1) ◽  
pp. 110-115
Author(s):  
Sunhaji Sunhaji
Keyword(s):  
Process Approach ◽  
Critical Education ◽  
Human Right ◽  
National History ◽  
Student Centered ◽  
Self Identity ◽  
Education Model ◽  
Learning Concept ◽  
Education Process

The process of education must apply with “Learning Process Skill”, not “Learning Concept”. Process approach marked with student centered curricula, not teacher centered. Role of teacher is as facilitator, mediator, dynamizing, organizing, and catalyst to apply “dialog” as spirit of education process. Critical education model is an education that independent from internal-institutional fetter, social hegemony, or structured to maintain political and economical stability. These happen in the length of our national history, then produce tame-weak human accorded to system condition. Whereas, education is human right, even people right to enhance its maturity, self-identity, and independence to serve his function to his God. .

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