3DTV Advocacy and System-Level Research Initiatives

2010 ◽  
pp. 221-254
Keyword(s):  
System Level ◽  
Research Initiatives

scholarly journals From what we know to what we do: enhancing absorptive capacity in translational health research

BMJ Leader ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 18-20
Author(s):  
Graeme Currie ◽  
Tina Kiefer ◽  
Dimitrios Spyridonidis
Keyword(s):  
Absorptive Capacity ◽  
Health Research ◽  
Public Involvement ◽  
Scale Up ◽  
Healthcare Delivery ◽  
Patient And Public Involvement ◽  
System Level ◽  
Science Literature ◽  
Knowledge Brokers ◽  
Research Initiatives

BackgroundGlobally, evidence about what works is slow to translate into frontline healthcare delivery. As a response, government policy has focused on translational health initiatives, such as the National Institute for Health Research funded Applied Research Collaborations in England. Concepts from organisation science prove useful to support such translational initiatives. We critique the application of two organisation science concepts linked to the broad domain of what is commonly termed ‘knowledge mobilisation’ in healthcare settings, specifically ‘knowledge brokers’ and ‘absorptive capacity’, to provide lessons for leaders of translational initiatives.ResultsThe presence of knowledge brokers to ‘move from what we know to what we do’ in healthcare delivery appears necessary but insufficient to have a system level effect. To embed knowledge brokers in the wider healthcare system so they draw on various sources of evidence to discharge their role with greatest effect, we encourage leaders of translational health research initiatives to take account of the concept of absorptive capacity (ACAP) from the organisation science literature. Leaders should focus on enhancing ACAP though development of ‘co-ordination capabilities’. Such co-ordination capability should aim not just to acquire different types of evidence, but to ensure that all types of evidence are used to develop, implement and scale up healthcare delivery that best benefits patients. Specific co-ordination capabilities that support translation of evidence are: clinician involvement in research and its implementation; patient and public involvement in research and its implementation; business intelligence structures and processes at organisational and system level.ConclusionAttention to the dimensions and antecedents of ACAP, alongside the implementation of the knowledge brokering solution, in translational health research initiatives, is likely to better ensure the latter’s success.

Where do we stand? Comparing system-level service lines in the private sector and in VHA

1998 ◽  
Author(s):  
Martin P. Charns ◽  
Victoria A. Parker ◽  
William H. Wubbenhorst
Keyword(s):  
Private Sector ◽  
System Level

Resilient futures: An individual and system-level approach to improve the well-being and resilience of disadvantaged young Australians.

2018 ◽  
Vol 4 (3) ◽  
pp. 228-244 ◽  
Author(s):  
Ivan J. Raymond ◽  
Matthew Iasiello ◽  
Aaron Jarden ◽  
David Michael Kelly
Keyword(s):  
Well Being ◽  
System Level

Gradient based system-level diagnosis

2007 ◽  
Vol 51 (1-2) ◽  
pp. 43
Author(s):  
Balázs Polgár ◽  
Endre Selényi
Keyword(s):  
System Level ◽  
Gradient Based

Insurgent Collaboration

2020 ◽  
Vol 9 (1) ◽  
pp. 106-110
Author(s):  
Linda E. Sánchez ◽  
Susan Bibler Coutin
Keyword(s):  
Central America ◽  
Educational Programs ◽  
Immigrant Communities ◽  
Research Model ◽  
Research Initiatives ◽  
Do So

Scholarship regarding those who are categorized as undocumented can put sanctuary principles into practice in research settings. To do so, scholars can conduct research in collaboration with immigrant communities, reject essentializing terminology, develop modes of sociality that challenge exclusion, and document the unofficial forms of sanctuary devised by members of immigrant communities. This research model is grounded in principles of accompaniment that were followed by 1980s activists who offered sanctuary to those fleeing wars in Central America. Examples of research initiatives and educational programs that follow such principles are presented.

Interconnect Limits on Gigascale Integration (GSI)

1997 ◽  
Vol 473 ◽  
Author(s):  
J. A. Davis ◽  
J. D. Meindl
Keyword(s):  
Response Time ◽  
Length Distribution ◽  
Path Model ◽  
System Level ◽  
Wire Length ◽  
Clock Frequency ◽  
Gigascale Integration ◽  
Logic Network ◽  
Binary Switching ◽  
Quantitative Definition

ABSTRACTOpportunities for Gigascale Integration (GSI) are governed by a hierarchy of physical limits. The levels of this hierarchy have been codified as: 1) fundamental, 2) material, 3) device, 4) circuit and 5) system. Many key limits at all levels of the hierarchy can be displayed in the power, P, versus delay, td, plane and the reciprocal length squared, L-2, versus response time, τ, plane. Power, P, is the average power transfer during a binary switching transition and delay, td, is the time required for the transition. Length, L, is the distance traversed by an interconnect that joins two nodes on a chip and response time, τ, characterizes the corresponding interconnect circuit. At the system level of the hierarchy, quantitative definition of both the P versus td and the L-2 versus τ displays requires an estimate of the complete stochastic wiring distribution of a chip.Based on Rent's Rule, a well known empirical relationship between the number of signal input/output terminals on a block of logic and the number of gate circuits with the block, a rigorous derivation of a new complete stochastic wire length distribution for an on-chip random logic network is described. This distribution is compared to actual data for modern microprocessors and to previously described distributions. A methodology for estimating the complete wire length distribution for future GSI products is proposed. The new distribution is then used to enhance the critical path model that determines the maximum clock frequency of a chip; to derive a preliminary power dissipation model for a random logic network; and, to define an optimal architecture of a multilevel interconnect network that minimizes overall chip size. In essence, a new complete stochastic wiring distribution provides a generic basis for maximizing the value obtained from a multilevel interconnect technology.

The role of inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy as a result of ART

2016 ◽  
pp. 73-76
Author(s):  
B.M. Ventskivskiy ◽  
◽  
I.V. Poladych ◽  
S.O. Avramenko ◽  
◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Inflammatory Cytokines ◽  
Proinflammatory Cytokines ◽  
Local Level ◽  
Multiple Pregnancy ◽  
Reproductive Technology ◽  
System Level ◽  
Premature Labor ◽  
Pro Inflammatory Cytokines

In recent years there has been an increase in the frequency of multiple pregnancies and the associated perinatal losses. It is a result of multiple pregnancy in ART refers to a high-risk gestation, at which premature births occur in 2 times more often than in singleton pregnancies. The objective: to determine the role of pro-inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy, as a result of assisted reproductive technology. Patients and methods. to determine the pro-inflammatory cytokines that all pregnant with bagtopliddyam held immunosorbent assay, defined concentrations of interleukin (IL) in serum and cervical mucus. Results. The analysis of the levels of pro-inflammatory cytokines (IL-1, IL-8) in the test environment, found high concentrations in the surveyed women with multiple pregnancy, due to the use of ART, compared with spontaneous multiple and singleton pregnancy. Increased concentration of proinflammatory cytokines in patients with multiple pregnancy by ART is associated with their synthesis at the system level, it stimulated foci of inflammation in the female genitals and extragenital localization. This correlates with the clinical data and statistical analysis, patients with multiple pregnancy as a result of ART had weighed infectious-inflammatory history. Conclusion. The study showed that elevated levels of proinflammatory cytokines in the systemic and local level in patients with multiple pregnancy due to ART, typical for women with miscarriage, because of the physiological course of pregnancy characterized by the predominance of anti-inflammatory cytokines that prevent rejection of the fetus as a foreign factor. Based on the data obtained proved the role of systemic inflammatory factors in the genesis of preterm labor in women with a multiple pregnancy, as a result of assisted reproductive technology. Key words: multiple pregnancy, assisted reproductive technology, premature birth, interleukine-1, interleukine-8.

EGM at the system level

2017 ◽  
Author(s):  
Adrian Bejan
Keyword(s):  
System Level
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