Pulmonary Neuroepithelial Cells in Mammals

2009 ◽  
pp. 234a-234a
Keyword(s):  
Neuroepithelial Cells

scholarly journals DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction

2019 ◽  
Vol 30 (16) ◽  
pp. 1900-1910 ◽  
Author(s):  
Arthur Marivin ◽  
Mikel Garcia-Marcos
Keyword(s):  
G Protein ◽  
Cultured Cells ◽  
Apical Cell ◽  
Cell Junctions ◽  
Binding Motif ◽  
Apical Constriction ◽  
Protein Activation ◽  
Neuroepithelial Cells ◽  
Two Factors ◽  
Apical Junctions

Dishevelled-Associating Protein with a high frequency of LEucines (DAPLE) belongs to a group of unconventional activators of heterotrimeric G-proteins that are cytoplasmic factors rather than membrane proteins of the G-protein–coupled receptor superfamily. During neurulation, DAPLE localizes to apical junctions of neuroepithelial cells and promotes apical cell constriction via G-protein activation. While junctional localization of DAPLE is necessary for this function, the factors it associates with at apical junctions or how they contribute to DAPLE-mediated apical constriction are unknown. MPDZ is a multi-PDZ (PSD95/DLG1/ZO-1) domain scaffold present at apical cell junctions whose mutation in humans is linked to nonsyndromic congenital hydrocephalus (NSCH). DAPLE contains a PDZ-binding motif (PBM) and is also mutated in human NSCH, so we investigated the functional relationship between both proteins. DAPLE colocalized with MPDZ at apical cell junctions and bound directly to the PDZ3 domain of MPDZ via its PBM. Much like DAPLE, MPDZ is induced during neurulation in Xenopus and is required for apical constriction of neuroepithelial cells and subsequent neural plate bending. MPDZ depletion also blunted DAPLE-­mediated apical constriction of cultured cells. These results show that DAPLE and MPDZ, two factors genetically linked to NSCH, function as cooperative partners at apical junctions and are required for proper tissue remodeling during early stages of neurodevelopment.

scholarly journals Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

2021 ◽  
Author(s):  
Ugomma C. Eze ◽  
Aparna Bhaduri ◽  
Maximilian Haeussler ◽  
Tomasz J. Nowakowski ◽  
Arnold R. Kriegstein
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Single Cell ◽  
Radial Glia ◽  
Cortical Development ◽  
Cell Types ◽  
Human Cortex ◽  
Early Stages ◽  
Human Brain Development ◽  
Neuroepithelial Cells

AbstractThe human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the developing human brain, including the telencephalon, diencephalon, midbrain, hindbrain and cerebellum. We identify nine progenitor populations physically proximal to the telencephalon, suggesting more heterogeneity than previously described, including a highly prevalent mesenchymal-like population that disappears once neurogenesis begins. Comparison of human and mouse progenitor populations at corresponding stages identifies two progenitor clusters that are enriched in the early stages of human cortical development. We also find that organoid systems display low fidelity to neuroepithelial and early radial glia cell types, but improve as neurogenesis progresses. Overall, we provide a comprehensive molecular and spatial atlas of early stages of human brain and cortical development.

Monstrous, crablike hypertrophy of the cerebellar vermis and its relationship with Lhermitte—Duclos disease

1996 ◽  
Vol 85 (1) ◽  
pp. 157-162 ◽  
Author(s):  
Guillermo A. de León ◽  
John A. Grant ◽  
Crystal F. Darling
Keyword(s):  
Surgical Resection ◽  
Basic Structure ◽  
Cerebellar Vermis ◽  
Biological Behavior ◽  
Content Type ◽  
Neuroepithelial Cells ◽  
Poorly Differentiated ◽  
New Interpretation ◽  
Fine Print

✓ The case of an infant with a peculiar tumorous malformation of the cerebellum is described. The tumor apparently developed as an exophytic, hypertrophic sprout of the inferior vermis. It had a monstrous appearance resembling a crab, with a metameric body and multiple pairs of limbs attached to the folia of both cerebellar hemispheres. Histologically, the lesion was formed by poorly differentiated neuroepithelial cells without any evidence of organization into nuclei, cortex, or fascicles. Clinically, the tumor behaved in an indolent manner and did not regrow after subtotal surgical resection. Because of its gross appearance and its biological behavior, this unusual hamartoblastomatous growth is readily distinguished from medulloblastoma. The morphology of the cerebellum in Lhermitte—Duclos disease is reviewed, and a new interpretation of its basic structure is proposed. This and other known types of cerebellar hypertrophy are different from the malformation in the present case.

A short term analysis of the behaviour of conditionally immortalized neuronal progenitors and primary neuroepithelial cells implanted into the fetal rat brain

1994 ◽  
Vol 83 (2) ◽  
pp. 197-208 ◽  
Author(s):  
Elena Cattaneo ◽  
Lorenzo Magrassi ◽  
Giorgio Butti ◽  
Laura Santi ◽  
Alessio Giavazzi ◽  
...  
Keyword(s):  
Rat Brain ◽  
Short Term ◽  
Neuronal Progenitors ◽  
Fetal Rat ◽  
Neuroepithelial Cells ◽  
Term Analysis ◽  
Fetal Rat Brain

Effects of FGF-1 and FGF-2 on GD3 immunoreactive spinal neuroepithelial cells

1996 ◽  
Vol 45 (5) ◽  
pp. 549-557 ◽  
Author(s):  
P.G. Bannerman ◽  
T.M. Oliver ◽  
Z. Xu ◽  
A. Shieh ◽  
D.E. Pleasure
Keyword(s):  
Neuroepithelial Cells

Instability of Notch1 and Delta1 mRNAs and reduced Notch activity in vertebrate neuroepithelial cells undergoing S-phase

2008 ◽  
Vol 37 (4) ◽  
pp. 820-831 ◽  
Author(s):  
Elsa Cisneros ◽  
Maria Jesús Latasa ◽  
Marta García-Flores ◽  
José María Frade
Keyword(s):  
S Phase ◽  
Notch Activity ◽  
Neuroepithelial Cells

Developmental expression of mouse stromelysin-3 mRNA

Development ◽  
1995 ◽  
Vol 121 (4) ◽  
pp. 947-955 ◽  
Author(s):  
O. Lefebvre ◽  
C. Regnier ◽  
M.P. Chenard ◽  
C. Wendling ◽  
P. Chambon ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mesenchymal Cells ◽  
Developmental Expression ◽  
Spatiotemporal Pattern ◽  
Commissural Axons ◽  
Embryonic Tissues ◽  
Trophoblastic Cells ◽  
Neuroepithelial Cells ◽  
Stromelysin 3

We have used northern blot analysis and in situ hybridization to study the spatial distribution of stromelysin-3 (ST3) expression during mouse embryogenesis. ST3 mRNA was observed in trophoblastic cells at the site of embryonic implantation (7.5-8.5 days) and in a variety of developing embryonic tissues. In these tissues, the highest ST3 expression levels were observed during the development of the external features of limb, tail and snout, and during bone and spinal cord morphogenesis. In limb, tail and snout, ST3 expression was specifically detected in mesenchymal cells lining the basement membrane at the junction of primitive dermis and epidermis, and adjacent to epithelial cells undergoing proliferation and/or apoptosis. In bone, ST3 was expressed in invasive mesenchymal cells and, in the spinal cord in neuroepithelial cells of the floor plate, at the time that this structure is crossed by commissural axons. Altogether, these observations suggest a role for ST3 during embryonic morphogenesis, in tissue remodeling processes associated with cell proliferation, death and/or invasion. Moreover, when compared to urokinase and tissue plasminogen activators, the spatiotemporal pattern of ST3 expression shows some similarities, but was not completely superimposable, suggesting that these genes may cooperate in some developing tissues and have specific functions in others.

Neuroepithelial cells in fish gill primary lamellae

1982 ◽  
Vol 53 (6) ◽  
pp. 1342-1353 ◽  
Author(s):  
S. Dunel-Erb ◽  
Y. Bailly ◽  
P. Laurent
Keyword(s):  
Electron Microscope ◽  
Basal Lamina ◽  
Direct Contact ◽  
External Medium ◽  
Nerve Fibers ◽  
Fish Gill ◽  
Neuroepithelial Cells ◽  
Internal Side ◽  
Lung Airways ◽  
Specific Membrane

Formaldehyde-induced fluorescence reveals numerous serotonin-containing cells within the primary epithelium of the fish gill. These cells are isolated or clustered and are supported by the epithelial basal lamina. They never reach the external medium and are found on the internal side of the primary lamellae, facing the respiratory water flow. With the electron microscope, these cells are found to contain dense-cored vesicles (DCV) of 80–100 nm. Nerve profiles are consistently found close to DCV cells. After having crossed the basal lamina, nerve fibers form endings on DCV-containing cells. These endings display both small clear vesicles and DCV and are in direct contact with DCV cells. Specific membrane alterations are suggestive of efferent synapses. These cells are considered neuroepithelial cells, similar to those found within the wall of lung airways in mammals and submammalian vertebrates. Structure and localization are suggestive of a tissue O2 sensor.

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