Ion Exchange Resins in Drug Delivery

2007 ◽  
pp. 103-150
Author(s):  
Sunil K. Bajpai ◽  
Manjula Bajpai ◽  
Sutanjay Saxena
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Ion Exchange Resins ◽  
Exchange Resins

Applications of Ion Exchange Resin in Oral Drug Delivery Systems

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
Kathpalia Harsha ◽  
Das Sukanya
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Drug Delivery Systems ◽  
Oral Drug Delivery ◽  
Physical Stability ◽  
Delivery Systems ◽  
Oral Drug ◽  
Ion Exchange Resins ◽  
Exchange Resins ◽  
Oral Drug Delivery Systems

Ion Exchange Resins (IER) are insoluble polymers having styrene divinylbenzene copolymer backbone that contain acidic or basic functional groups and have the ability to exchange counter ions with the surrounding aqueous solutions. From the past many years they have been widely used for purification and softening of water and in chromatographic columns, however recently their use in pharmaceutical industry has gained considerable importance. Due to the physical stability and inert nature of the resins, they can be used as a versatile vehicle to design several modified release dosage forms The ionizable drug is complexed with the resin owing to the property of ion exchange. This resin complex dissociatesin vivo to release the drug. Based on the dissociation strength of the drug from the drug resin complex, various release patterns can be achieved. Many formulation glitches can be circumvented using ion exchange resins such as bitter taste and deliquescence. These resins also aid in enhancing disintegrationand stability of formulation. This review focuses on different types of ion exchange resins, their preparation methods, chemistry, properties, incompatibilities and their application in various oral drug delivery systems as well as highlighting their use as therapeutic agents.

Ion Exchange Resins Transforming Drug Delivery Systems

2010 ◽  
Vol 7 (3) ◽  
pp. 252-262 ◽  
Author(s):  
Shweta Gupta ◽  
Parul Benien ◽  
P.K. Sahoo
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ion Exchange Resins ◽  
Exchange Resins

Ion-exchange resins: carrying drug delivery forward

2001 ◽  
Vol 6 (17) ◽  
pp. 905-914 ◽  
Author(s):  
Vikas Anand ◽  
Raghupathi Kandarapu ◽  
Sanjay Garg
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Ion Exchange Resins ◽  
Exchange Resins

scholarly journals Ion-Exchange Resins as Controlled Drug Delivery Carriers

2010 ◽  
Vol 2 (3) ◽  
pp. 597 ◽  
Author(s):  
M. V. Srikanth ◽  
S. A. Sunil ◽  
N. S. Rao ◽  
M. U. Uhumwangho ◽  
K. V. Ramana Murthy
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Exchange Resin ◽  
Cation Exchange Resin ◽  
Controlled Drug Delivery ◽  
Ion Exchange Resin ◽  
Ion Exchange Resins ◽  
Exchange Cation ◽  
Therapeutic Applications ◽  
Exchange Resins

Ion exchange resins (IER) are insoluble polymers that contain acidic or basic functional groups and have the ability to exchange counter-ions within aqueous solutions surrounding them. Based on the nature of the exchangeable ion of the resin as a cation or anion, it is classified as cationic or anionic exchange resins, respectively. The efficacy of ion exchange resins mainly depends upon their physical properties such as degree of cross-linking, porosity, acid base strength, stability, purity and particle size. Modified release of drugs from resinate (drug-resin complexes) is another potential application of ion exchange resins.  Due to the versatile utility of ion exchange resins, they are being used for various drug delivery and therapeutic applications. Resins used are polymers that contain appropriately substituted acidic groups, such as carboxylic and sulfonic for cation exchangers; or basic groups, such as quaternary ammonium group for anion exchangers. This review addresses different types of ion exchange resin, their properties, the chemistry; role of IER in controlled drug delivery systems, its therapeutic applications, methods of preparation of IER along with their resonates. Keywords: Anion exchange; Cation exchange; Resin; Controlled release; Resinates; Drug delivery. © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i3.4991               J. Sci. Res. 2 (3), 599-613 (2010) 

Ion Exchange Resins in Gastroretentive Drug Delivery: Characteristics, Selection, Formulation and Applications

2014 ◽  
Vol 1 (4) ◽  
pp. 304-312 ◽  
Author(s):  
Praveen Kumar Gaur ◽  
Shikha Mishra ◽  
Snigdha Bhardwaj ◽  
Dinesh Puri ◽  
S. Sadish Kumar
Keyword(s):  
Drug Delivery ◽  
Ion Exchange ◽  
Ion Exchange Resins ◽  
Exchange Resins
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