Families of Glutathione Transferases

2006 ◽  
pp. 11-26 ◽  
Author(s):  
Piotr Zimniak ◽  
Sharda Singh
Keyword(s):  
Glutathione Transferases

Expression and distribution of glutathione transferases in protoscoleces of Echinococcus granulosus sensu lato.

Acta Tropica ◽  
2021 ◽  
pp. 105991
Author(s):  
Paula Arbildi ◽  
Silvana La-Rocca ◽  
Alejandra Kun ◽  
Karina R. Lorenzato ◽  
Karina M. Monteiro ◽  
...  
Keyword(s):  
Echinococcus Granulosus ◽  
Glutathione Transferases ◽  
Echinococcus Granulosus Sensu Lato

scholarly journals Role of Glutathione Transferases in the Mechanism of Brostallicin Activation

Biochemistry ◽  
2010 ◽  
Vol 49 (1) ◽  
pp. 226-235 ◽  
Author(s):  
Silvia Pezzola ◽  
Giovanni Antonini ◽  
Cristina Geroni ◽  
Italo Beria ◽  
Maristella Colombo ◽  
...  
Keyword(s):  
Glutathione Transferases

Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization

2010 ◽  
Vol 431 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Natalia Fedulova ◽  
Françoise Raffalli-Mathieu ◽  
Bengt Mannervik
Keyword(s):  
Double Bond ◽  
Glutathione Transferase ◽  
Biological Species ◽  
Glutathione Transferases ◽  
Special Role ◽  
Primary Role ◽  
The Novel ◽  
Protective Function ◽  
Isomerase Activity

A primary role of GSTs (glutathione transferases) is detoxication of electrophilic compounds. In addition to this protective function, hGST (human GST) A3-3, a member of the Alpha class of soluble GSTs, has prominent steroid double-bond isomerase activity. The isomerase reaction is an obligatory step in the biosynthesis of steroid hormones, indicating a special role of hGST A3-3 in steroidogenic tissues. An analogous GST with high steroid isomerase activity has so far not been found in any other biological species. In the present study, we characterized a Sus scrofa (pig) enzyme, pGST A2-2, displaying high steroid isomerase activity. High levels of pGST A2-2 expression were found in ovary, testis and liver. In its functional properties, other than steroid isomerization, pGST A2-2 was most similar to hGST A3-3. The properties of the novel porcine enzyme lend support to the notion that particular GSTs play an important role in steroidogenesis.

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