scholarly journals Role of Glutathione Transferases in the Mechanism of Brostallicin Activation

Biochemistry ◽  
2010 ◽  
Vol 49 (1) ◽  
pp. 226-235 ◽  
Author(s):  
Silvia Pezzola ◽  
Giovanni Antonini ◽  
Cristina Geroni ◽  
Italo Beria ◽  
Maristella Colombo ◽  
...  
Keyword(s):  
Glutathione Transferases

Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization

2010 ◽  
Vol 431 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Natalia Fedulova ◽  
Françoise Raffalli-Mathieu ◽  
Bengt Mannervik
Keyword(s):  
Double Bond ◽  
Glutathione Transferase ◽  
Biological Species ◽  
Glutathione Transferases ◽  
Special Role ◽  
Primary Role ◽  
The Novel ◽  
Protective Function ◽  
Isomerase Activity

A primary role of GSTs (glutathione transferases) is detoxication of electrophilic compounds. In addition to this protective function, hGST (human GST) A3-3, a member of the Alpha class of soluble GSTs, has prominent steroid double-bond isomerase activity. The isomerase reaction is an obligatory step in the biosynthesis of steroid hormones, indicating a special role of hGST A3-3 in steroidogenic tissues. An analogous GST with high steroid isomerase activity has so far not been found in any other biological species. In the present study, we characterized a Sus scrofa (pig) enzyme, pGST A2-2, displaying high steroid isomerase activity. High levels of pGST A2-2 expression were found in ovary, testis and liver. In its functional properties, other than steroid isomerization, pGST A2-2 was most similar to hGST A3-3. The properties of the novel porcine enzyme lend support to the notion that particular GSTs play an important role in steroidogenesis.

Correction to Role of Glutathione Transferases in the Mechanism of Brostallicin Activation

Biochemistry ◽  
2010 ◽  
Vol 49 (23) ◽  
pp. 4930-4930
Author(s):  
Silvia Pezzola ◽  
Giovanni Antonini ◽  
Cristina Geroni ◽  
Italo Beria ◽  
Maristella Colombo ◽  
...  
Keyword(s):  
Glutathione Transferases

scholarly journals Susceptibility Level of the Colorado Potato Beetle (Leptinotarsa Decemlineata Say) to Chlorpyrifos and Acetamiprid in Poland and Resistance Mechanisms of the Pest to Chlorpyrifos

2011 ◽  
Vol 51 (3) ◽  
pp. 279-284 ◽  
Author(s):  
Paweł Węgorek ◽  
Joanna Zamojska ◽  
Marek Mrówczyński
Keyword(s):  
Colorado Potato Beetle ◽  
Oxidative Metabolism ◽  
Leptinotarsa Decemlineata ◽  
Essential Role ◽  
Resistance Mechanisms ◽  
Glutathione Transferases ◽  
Main Role ◽  
Potato Beetle ◽  
Leptinotarsa Decemlineata Say

Susceptibility Level of the Colorado Potato Beetle (Leptinotarsa DecemlineataSay) to Chlorpyrifos and Acetamiprid in Poland and Resistance Mechanisms of the Pest to ChlorpyrifosNowadays, neonicotinoids play an essential role in the control of the Colorado potato beetle (CPB) in Poland. Taking into consideration that CPB shows some resistance to pyrethroids and the main role of oxidative metabolism in this resistance, research was conducted to estimate CPB susceptibility level to chlorpyrifos and acetamiprid. The results pointed to a lack of CPB resistance to acetamiprid and a weak susceptibility level to chlorpyrifos by the CPB. For this reason, the second part of the experiment was aimed at detecting the resistance mechanisms of the CPB to chlorpyrifos. Results showed that none of the tested enzyme groups (oxidases, esterases and glutathione transferases) are the reason for CPB resistance to chlorpyrifos. The experiments revealed an increase in the beetles survival after adding oxidative enzyme blocker to chlorpyrifos.

Heme Transport and Detoxification in Nematodes: Subproteomics Evidence of Differential Role of Glutathione Transferases

2008 ◽  
Vol 7 (10) ◽  
pp. 4557-4565 ◽  
Author(s):  
Samïrah Perally ◽  
E. James LaCourse ◽  
Alison M. Campbell ◽  
Peter M. Brophy
Keyword(s):  
Glutathione Transferases ◽  
Heme Transport

scholarly journals Biochemical Warfare on the Reef: The Role of Glutathione Transferases in Consumer Tolerance of Dietary Prostaglandins

PLoS ONE ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. e8537 ◽  
Author(s):  
Kristen E. Whalen ◽  
Amy L. Lane ◽  
Julia Kubanek ◽  
Mark E. Hahn
Keyword(s):  
Glutathione Transferases

The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population

2006 ◽  
Vol 33 (5-6) ◽  
pp. 529-535 ◽  
Author(s):  
Slah Ouerhani ◽  
Fethi Tebourski ◽  
Mohamed Riadh Ben Slama ◽  
Raja Marrakchi ◽  
Mariam Rabeh ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Glutathione Transferases ◽  
Tunisian Population ◽  
Individual Susceptibility

scholarly journals Molecular evolution and the role of oxidative stress in the expansion and functional diversification of cytosolic glutathione transferases

2010 ◽  
Vol 10 (1) ◽  
pp. 281 ◽  
Author(s):  
Rute R da Fonseca ◽  
Warren E Johnson ◽  
Stephen J O'Brien ◽  
Vítor Vasconcelos ◽  
Agostinho Antunes
Keyword(s):  
Oxidative Stress ◽  
Molecular Evolution ◽  
Glutathione Transferases ◽  
Functional Diversification ◽  
Cytosolic Glutathione

The role of the Aedes aegypti Epsilon glutathione transferases in conferring resistance to DDT and pyrethroid insecticides

2011 ◽  
Vol 41 (3) ◽  
pp. 203-209 ◽  
Author(s):  
Nongkran Lumjuan ◽  
Shavanthi Rajatileka ◽  
Donch Changsom ◽  
Jureeporn Wicheer ◽  
Posri Leelapat ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Glutathione Transferases ◽  
Pyrethroid Insecticides
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