Recognition, treatment, and prevention of systemic allergic reactions and anaphylaxis *

2020 ◽  
pp. 549-567
Author(s):  
Emma Westermann-Clark ◽  
Stephen F. Kemp ◽  
Richard D. deShazo
Author(s):  
Concepción De Linares ◽  
David Navarro ◽  
Rut Puigdemunt ◽  
Jordina Belmonte

Fungal spores are universal atmospheric components associated to allergic reactions. Alternaria (Ascomycota) is considered the most allergenic spore taxa. Alt a 1 is the major allergen of Alternaria and is present also in other Pleosporales. In this study, standard Hirst-based sampling and analyzing methods for measuring spore daily concentrations of Alternaria, Curvularia, Drechslera-Helminthosporium, Epicoccum, Leptosphaeria, Pithomyces, Pleospora and Stemphyllium (all included in the taxon Pleosporales) have been used besides two high-volume samplers, Burkard Cyclone (2017) and MCV CAV-A/mb (2019-2020), and ELISA Kits for measuring the allergen. The detection and quantification of Alt a 1 was only possible in the samples from the MCV sampler. Although Alt a 1 was better correlated with Alternaria spores than with Pleosporales spores, the three of them showed high correlations. It is shown, for the first time, a high and significant correlation of Alt a 1 with temperature, a negative one with relative humidity and no correlation with precipitation. The aerobiological monitoring of these three elements ensures the best information for understanding the affectation to allergy sufferers but, if not possible, as a minimum public health service aiming at the detection, treatment and prevention of allergy, the study of the airborne Alternaria spores should be ensured.


Author(s):  
Allа Shlianina ◽  
Iryna Shelyuk ◽  
Svitlana Mulenko ◽  
Olena Shemet

The growing number of allergic diseases among people is a global problem. The article considers the role of educational work among students as an important component of knowledge formation about the causes of allergic diseases, prevention methods and maintaining a healthy lifestyle. It is established, that this problem is relevant in the world and requires the introduction of a system of measures to overcome it. The prevalence of allergic diseases has tripled in the last 10 years and to date allergies have reached pandemic proportions. The stages of allergic reactions and possible causes of allergic diseases (genetic, environmental, social) are indicated. The result of immunodeficiency as a result of allergies is the development of various complications or chronic diseases that can lead to disability and even death. The complex epidemiological situation in the world with a large increase in the number of allergic diseases requires constant monitoring to understand current trends. It is taken into account, that there are no statistical data on the level of prevalence of allergic diseases among the population of Ukraine, the study of epidemiological and preventive areas is relevant. The problem of allergic manifestations was considered among the applicants for education of Zhytomyr Pharmaceutical Basic Vocational College. It has been found, that students of the college already have certain professional competencies: demonstrate knowledge and understanding of the concept of "allergy", the manifestation of allergies, treat the causes and ways of the disease, methods of diagnosing allergens, are informed about historical aspects of disease recognition. It has been proven, that issues, related to allergies, worry students because of the causes of their allergic reactions and diseases. It has been found, that students want to continue to receive and deepen modern knowledge on prevention, causes and types of allergic manifestations and ways to eliminate them. As a result of the analysis the actual questions of students and the necessary answer to them, teachers and specialists-allergists have been revealed. The importance of information work among applicants for pharmaceutical education, which in their daily work will constantly use toxic substances, drugs and cosmetics that contain substances – allergens, has been traced. Substantiation of the need to develop effective systems of actions for prevention, diagnosis and provision of treatment and prevention care to the population has been presented


1984 ◽  
Vol 62 (8) ◽  
pp. 1044-1048 ◽  
Author(s):  
W. D. Black

Antibacterial drugs have been used widely in animal production for treatment and prevention of disease and for growth promotion. Concern has been expressed about possible harm to humans, through the use of drugs, in the following ways: (1) increased microbial drug resistance; (2) drug residues in food; (3) allergic reactions and sensitization to antimicrobials; and (4) drug toxicity. Research has shown that microbial resistance in people can develop from drugs used in animals. Farmers, butchers, etc., have been shown to have an increased incidence of drug-resistant organisms. Resistance to antibiotics can develop in two ways; genetic mutation and natural selection, and through R-factor plasmid transfer. Allergic reactions have been reported following the ingestion of penicillin-containing milk; however, residues in other foods have not caused allergic reactions. Sensitization of humans to antimicrobials through the consumption of drug residues in foods has never been documented. Evidence suggests that the residue levels in food are too low to cause sensitization. Drug toxicity, other than allergic reactions, appears not to result from residues of antimicrobial drugs in food. While it has been studied many times, monitoring programs have failed to find any evidence of a problem. This appears to reflect the low toxicity of these agents and the small amounts obtained in the food, however, it could also reflect failure of the monitoring systems.


2011 ◽  
Vol 81 (23) ◽  
pp. 173-180 ◽  
Author(s):  
Barbara K. Ballmer-Weber

Four to eight percent of the population are estimated to be food-allergic. Most food allergies in adolescents and adults are acquired on the basis of cross-reaction to pollen allergens. Theses allergens are ubiquitous in the plant kingdom. Therefore pollen-allergic patients might acquire a multitude of different plant food allergies, and even react to novel foods to which they have never previously been exposed. A curative therapy for food allergy does not yet exist. Food-allergic patients have to rely on strict avoidance diets, The widespread use of industrially processed foods poses a general problem for food-allergic patients. Although the most frequent allergens must be declared openly in the list of ingredients, involuntary contamination with allergy-provoking compounds can occur. The precautionary labelling “may contain” is sometimes applied even if the chance of contamination is very low; on the other hand, foods not declared to contain possible traces of allergenic components may actually contain relevant amounts of allergenic proteins. Switzerland is the only country in Europe with legal regulations on contamination by allergenic food; however, the allowance of 1 g/kg is too high to protect a relevant proportion of food-allergic individuals.


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