Tissue Engineering Systems

2003 ◽  
Author(s):  
Karen Burg ◽  
Chuck Thomas
Keyword(s):  
Tissue Engineering ◽  
Engineering Systems

scholarly journals Advanced mycelium materials as potential self-growing biomedical scaffolds

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Elena Antinori ◽  
Marco Contardi ◽  
Giulia Suarato ◽  
Andrea Armirotti ◽  
Rosalia Bertorelli ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Low Cost ◽  
Direct Interaction ◽  
Dermal Fibroblasts ◽  
Engineering Systems ◽  
Edible Fungi ◽  
Avant Garde ◽  
Fibrous Network ◽  
Body Tissues ◽  
Wide Range

AbstractMycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physical properties can be adjusted depending on the conditions of growth and the substrate they are fed upon. So far, only extracts and derivatives from mycelia have been evaluated and tested for biomedical applications. In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. To this purpose, the two mycelial strains are inactivated by autoclaving after growth, and their morphology, cell wall chemical composition, and hydrodynamical and mechanical features are studied. Finally, their biocompatibility and direct interaction with primary human dermal fibroblasts are investigated. The findings demonstrate the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.

scholarly journals Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications

2012 ◽  
Vol 2 (5) ◽  
pp. 439-449 ◽  
Author(s):  
Tapan Kumar Giri ◽  
Amrita Thakur ◽  
Amit Alexander ◽  
Ajazuddin ◽  
Hemant Badwaik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Present Status ◽  
Engineering Systems ◽  
Modified Chitosan ◽  
Chitosan Hydrogels

Case Studies in Tissue Engineering

2004 ◽  
Author(s):  
W. Mark Saltzman
Keyword(s):  
Tissue Engineering ◽  
Cultured Cells ◽  
Femoral Condyle ◽  
Nerve Repair ◽  
Cartilage Tissue Engineering ◽  
Cartilage Defects ◽  
Engineering Systems ◽  
Cross Sectional ◽  
Healthy Knee

This final chapter introduces a few tissue engineering systems that either have been used clinically or are rapidly approaching clinical use for cartilage, skin, and nerve repair. Some of the elements of each tissue engineering system are presented, together with references to the primary literature. The first example involves engineering of a tissue with an important mechanical function: cartilage. The general approach described for cartilage has been attempted in other structural tissues such as bone, tendon, and skin; there are important common elements among these tissue engineering systems. One common underlying theme, which is emphasized in the first example, is the use of a material as a scaffold for the ingrowth, proliferation, and function of cells, which differentiate into mature functional cells. After being introduced to this first example and provided with an outline of some experimental results, the reader is then presented with a series of questions: some are intended to stimulate discussion in the classroom, while others can be used as homework assignments or as the basis for independent projects. The main objective of these exercises is to assimilate information from previous chapters and apply it in a situation with clinical application: cartilage tissue engineering. The second and third examples involve tissue-engineered skin and repair of nerves lost to disease or trauma. No questions are provided with these examples, but the reader is encouraged to identify the connections to material in the preceding chapters. One of the first tissue engineering products available to patients is Carticel1®, which uses autologous cultured chondrocytes for the repair of cartilage defects in the femoral condyle (spirally curved prominences on the end of the femur that is involved in the knee joint). The procedure has several phases: first, a pea-sized biopsy of healthy knee cartilage is obtained. This tissue is expanded in vitro to obtain a large number of cultured cells that are all derived from the patient. In a second procedure, a surgeon prepares the transplant site by removing diseased tissue and preparing the defect (in the clinical trials of this product, the defect had a cross-sectional area of <1 to 20 cm2, with 90% of the defects <10 cm2).

scholarly journals Marine Seaweed Polysaccharides-Based Engineered Cues for the Modern Biomedical Sector

Marine Drugs ◽  
2019 ◽  
Vol 18 (1) ◽  
pp. 7 ◽  
Author(s):  
Bilal ◽  
Iqbal
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Targeted Drug Delivery ◽  
Methodological Approach ◽  
Controlled Delivery ◽  
Engineering Systems ◽  
Future Perspectives ◽  
Exclusion Criteria ◽  
Research Attention ◽  
Medical Sector

Seaweed-derived polysaccharides with unique structural and functional entities have gained special research attention in the current medical sector. Seaweed polysaccharides have been or being used to engineer novel cues with biomedical values to tackle in practice the limitations of counterparts which have become ineffective for 21st-century settings. The inherited features of seaweed polysaccharides, such as those of a biologically tunable, biocompatible, biodegradable, renewable, and non-toxic nature, urge researchers to use them to design therapeutically effective, efficient, controlled delivery, patient-compliant, and age-compliant drug delivery platforms. Based on their significant retention capabilities, tunable active units, swelling, and colloidal features, seaweed polysaccharides have appeared as highly useful materials for modulating drug-delivery and tissue-engineering systems. This paper presents a standard methodological approach to review the literature using inclusion-exclusion criteria, which is mostly ignored in the reported literature. Following that, numerous marine-based seaweed polysaccharides are discussed with suitable examples. For the applied perspectives, part of the review is focused on the biomedical values, i.e., targeted drug delivery, wound-curative potential, anticancer potentialities, tissue-engineering aspects, and ultraviolet (UV) protectant potential of seaweed polysaccharides based engineered cues. Finally, current challenges, gaps, and future perspectives have been included in this review.

scholarly journals Advanced Strategies for Tissue Engineering in Regenerative Medicine: A Biofabrication and Biopolymer Perspective

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2518
Author(s):  
Courtney R. Lynch ◽  
Pierre P. D. Kondiah ◽  
Yahya E. Choonara
Keyword(s):  
Tissue Engineering ◽  
Immune Response ◽  
Tissue Injury ◽  
The Body ◽  
Cell Regeneration ◽  
Engineering Systems ◽  
Limited Ability ◽  
Privileged Site ◽  
Severe Tissue ◽  
Natural Cell

Tissue engineering is known to encompass multiple aspects of science, medicine and engineering. The development of systems which are able to promote the growth of new cells and tissue components are vital in the treatment of severe tissue injury and damage. This can be done through a variety of different biofabrication strategies including the use of hydrogels, 3D bioprinted scaffolds and nanotechnology. The incorporation of stem cells into these systems and the advantage of this is also discussed. Biopolymers, those which have a natural original, have been particularly advantageous in tissue engineering systems as they are often found within the extracellular matrix of the human body. The utilization of biopolymers has become increasing popular as they are biocompatible, biodegradable and do not illicit an immune response when placed into the body. Tissue engineering systems for use with the eye are also discussed. This is of particular interest as the eye is known as an immune privileged site resulting in an extremely limited ability for natural cell regeneration.

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