Visualizing feasible operating ranges within tissue engineering systems using a “windows of operation” approach: A perfusion-scaffold bioreactor case study

2012 ◽  
Vol 109 (12) ◽  
pp. 3161-3171 ◽  
Author(s):  
Ryan J. McCoy ◽  
Fergal J. O'Brien
Keyword(s):  
Tissue Engineering ◽  
Engineering Systems

scholarly journals Advanced mycelium materials as potential self-growing biomedical scaffolds

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Elena Antinori ◽  
Marco Contardi ◽  
Giulia Suarato ◽  
Andrea Armirotti ◽  
Rosalia Bertorelli ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Low Cost ◽  
Direct Interaction ◽  
Dermal Fibroblasts ◽  
Engineering Systems ◽  
Edible Fungi ◽  
Avant Garde ◽  
Fibrous Network ◽  
Body Tissues ◽  
Wide Range

AbstractMycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physical properties can be adjusted depending on the conditions of growth and the substrate they are fed upon. So far, only extracts and derivatives from mycelia have been evaluated and tested for biomedical applications. In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. To this purpose, the two mycelial strains are inactivated by autoclaving after growth, and their morphology, cell wall chemical composition, and hydrodynamical and mechanical features are studied. Finally, their biocompatibility and direct interaction with primary human dermal fibroblasts are investigated. The findings demonstrate the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.

scholarly journals Modified chitosan hydrogels as drug delivery and tissue engineering systems: present status and applications

2012 ◽  
Vol 2 (5) ◽  
pp. 439-449 ◽  
Author(s):  
Tapan Kumar Giri ◽  
Amrita Thakur ◽  
Amit Alexander ◽  
Ajazuddin ◽  
Hemant Badwaik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Present Status ◽  
Engineering Systems ◽  
Modified Chitosan ◽  
Chitosan Hydrogels

Polymer Based Biointerfaces: A Case Study on Devices for Theranostics and Tissue Engineering

2010 ◽  
pp. 67-77 ◽  
Author(s):  
Pamela Mozetic ◽  
Mariarosaria Tortora ◽  
Barbara Cerroni ◽  
Gaio Paradossi
Keyword(s):  
Tissue Engineering

TRIZ Based Tool Management Applied in Mechanical Heart Valve Engineering Systems

2012 ◽  
Vol 569 ◽  
pp. 521-524
Author(s):  
Feng Zhou ◽  
Yuan Yuan Cui ◽  
Liang Liang Wu ◽  
Yin Chen ◽  
Jie Yang ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
Production Systems ◽  
Mechanical Heart Valve ◽  
Complex Case ◽  
Evolutionary Development ◽  
Prosthetic Heart Valves ◽  
Engineering Systems ◽  
Device Structure

Artificial mechanical heart valve (MHV) replacement is the common cardiovascular surgical procedure, yet its effect is far from satisfaction. Most important reasons lie in the model design and choice of the materials in the fabrication of the prosthetic heart valves. Based on systematic design methodology of TRIZ theory (Russian acronym for Theory of Solving Inventive Problem), the device structure is analyzed by comparing the past successful designs generated during the evolution of MHV. This paper represents a modeling technique integrating the well-established TRIZ with the conflict and contradiction modeling, substance-field and product functional analysis tools and provides some important trends in evolutionary development of production systems in MHV design. By analyzing the structural behavior and material performance, a complex case study from the research of different structural patterns and characteristics of current tri-leaflet modeling shows the validity of TRIZ theory to guide MHV design.

Poly(Lactic Acid)-Based Blends With Tailored Physicochemical Properties for Tissue Engineering Applications: A Case Study

2014 ◽  
Vol 64 (2) ◽  
pp. 90-98 ◽  
Author(s):  
Irene Carmagnola ◽  
Tiziana Nardo ◽  
Piergiorgio Gentile ◽  
Chiara Tonda-Turo ◽  
Clara Mattu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Physicochemical Properties ◽  
Poly Lactic Acid ◽  
Engineering Applications

Robust Design Through the Use of a Hybrid Genetic Algorithm

2002 ◽  
Author(s):  
Kurt Hacker ◽  
Kemper Lewis
Keyword(s):  
Robust Design ◽  
Hybrid Genetic Algorithm ◽  
Design Parameters ◽  
Optimization Approach ◽  
Engineering Systems ◽  
Local Optima ◽  
Good Design ◽  
Mean And Variance ◽  
The Mean

In this paper we present a hybrid optimization approach to perform robust design. The motivation for this work is the fact that many realistic engineering systems are mutimodal in nature with multiple local optima, and moreover may have one or more uncertain design parameters. The approach that is presented utilizes both local and global optimization algorithms to find good design points more efficiently than either could alone. The mean and variance of the objective function at a design point is calculated using Monte Carlo simulation and is used to drive the optimization process. To demonstrate the usefulness of this approach a case study is considered involving the design of a beam with dimensional uncertainty.

scholarly journals Comparative case study on system-integrated measurement technologies

2020 ◽  
Vol 15 (2) ◽  
pp. 60-69
Author(s):  
János Tóth ◽  
Balázs Kocsi
Keyword(s):  
Problem Solving ◽  
Engineering Education ◽  
Comparative Case Study ◽  
Detailed Knowledge ◽  
Engineering Systems ◽  
Different Types ◽  
Level Problem ◽  
High Level ◽  
Preference Matrix

Abstract:The aim of the research is to make a comparison between system integrated measurement technologies in the field of engineering education in order to the students getting more detailed knowledge about the high level problem solving. A comparative case study was conducted with 3 different types of systems, as follows: Beckhoff, National Instruments, and HBM. The criteria of the systems are determined based on experience and the importance level of them was calculated by preference matrix. The ranks of the alternatives are calculated by Kesselring method, which provides the effectiveness value of the systems compared to the benchmark. The result of the paper shows a suitable method for selecting engineering systems.

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