Particle Radiation Therapy Using Proton and Heavier Ion Beams

2007 ◽  
Vol 25 (8) ◽  
pp. 953-964 ◽  
Author(s):  
Daniela Schulz-Ertner ◽  
Hirohiko Tsujii
Keyword(s):  
Radiation Therapy ◽  
Particle Beam ◽  
Particle Beams ◽  
Particle Radiation ◽  
Dose Distributions ◽  
Normal Tissues ◽  
Tumor Visualization ◽  
Physics Laboratories ◽  
Beam Delivery ◽  
Particle Beam Therapy

Particle beams like protons and heavier ions offer improved dose distributions compared with photon (also called x-ray) beams and thus enable dose escalation within the tumor while sparing normal tissues. Although protons have a biologic effectiveness comparable to photons, ions, because they are heavier than protons, provide a higher biologic effectiveness. Recent technologic developments in the fields of accelerator engineering, treatment planning, beam delivery, and tumor visualization have stimulated the process of transferring particle radiation therapy (RT) from physics laboratories to the clinic. This review describes the physical, biologic, and technologic aspects of particle beam therapy. Clinical trials investigating proton and carbon ion RT will be summarized and discussed in the context of their relevance to recent concepts of treatment with RT.

scholarly journals A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond

2021 ◽  
Vol 11 (8) ◽  
pp. 825
Author(s):  
Yoshitaka Matsumoto ◽  
Nobuyoshi Fukumitsu ◽  
Hitoshi Ishikawa ◽  
Kei Nakai ◽  
Hideyuki Sakurai
Keyword(s):  
Radiation Therapy ◽  
Nuclear Reactions ◽  
Ion Beam ◽  
Multidisciplinary Treatment ◽  
Treatment Strategies ◽  
Particle Beam ◽  
Particle Therapy ◽  
High Dose ◽  
Therapeutic Effects ◽  
Particle Beam Therapy

In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has shown rapid progress and widespread use in recent years—in multidisciplinary treatment. Three types of particle therapies are currently used for cancer treatment: proton beam therapy (PBT), carbon-ion beam therapy (CIBT), and boron neutron capture therapy (BNCT). PBT and CIBT have been reported to have excellent therapeutic results owing to the physical characteristics of their Bragg peaks. Variable drug therapies, such as chemotherapy, hormone therapy, and immunotherapy, are combined in various treatment strategies, and treatment effects have been improved. BNCT has a high dose concentration for cancer in terms of nuclear reactions with boron. BNCT is a next-generation RT that can achieve cancer cell-selective therapeutic effects, and its effectiveness strongly depends on the selective 10B accumulation in cancer cells by concomitant boron preparation. Therefore, drug delivery research, including nanoparticles, is highly desirable. In this review, we introduce both clinical and basic aspects of particle beam therapy from the perspective of multidisciplinary treatment, which is expected to expand further in the future.

scholarly journals Radiation Necrosis of the Lateral Skull Base and Temporal Bone

2020 ◽  
Vol 34 (04) ◽  
pp. 265-271
Author(s):  
Marc W. Herr ◽  
Aurora G. Vincent ◽  
Meghan A. Skotnicki ◽  
Yadranko Ducic ◽  
Spiros Manolidis
Keyword(s):  
Radiation Therapy ◽  
Temporal Bone ◽  
Radiation Necrosis ◽  
Critical Role ◽  
Therapeutic Effects ◽  
Normal Tissues ◽  
Lateral Skull Base ◽  
The Many ◽  
Work Up

AbstractRadiation therapy plays a critical role in the treatment of malignancies involving the head and neck. Although the therapeutic effects of ionizing radiation are achieved, normal tissues are also susceptible to injury and significant long-term sequelae. Osteoradionecrosis of the temporal bone (ORNTB) is among the many complications that can arise after therapy. ORNTB is a debilitating and potentially lethal condition that continues to challenge patients and treating physicians. Herein, we review the pathophysiology, presentation, work-up, and management of ORNTB.

Radiotherapy scheduling using prime numbers

2013 ◽  
Vol 13 (3) ◽  
pp. 317-321
Author(s):  
J. McLaughlin ◽  
L. Marignol
Keyword(s):  
Radiation Therapy ◽  
Treatment Protocol ◽  
Reproductive Activity ◽  
Prime Numbers ◽  
Clinical Implementation ◽  
Normal Tissues ◽  
Dose Fraction ◽  
Dividing Cells ◽  
Biological Effectiveness ◽  
Therapy Treatment

AbstractBackgroundThe optimal delivery of radiation therapy to achieve maximum tumour cell kill while limiting damage to normal tissues underlies any radiation therapy treatment protocol. The biological effectiveness of radiation therapy is closely related to cellular reproductive activity. The scheduling of dose fraction to a time where actively dividing cells are at their most radiosensitive stage (RS) has potential to enhance therapeutic efficacy.Materials and methodsA prime number is a natural number >1 whose only divisors are 1 and the number itself.PurposeWe propose that the use of prime numbers in the scheduling of radiotherapy treatments could maximise biological effectiveness by facilitating the irradiation of the greatest number of cells at their most RS stage, and ultimately improve the therapeutic ratio of radiation therapy.ConclusionsThe theoretical clinical implementation of this concept into the scheduling of radiation therapy is discussed.

scholarly journals OC-0457: Towards analytic dose calculation for MR guided particle beam therapy

2016 ◽  
Vol 119 ◽  
pp. S214-S215
Author(s):  
H. Fuchs ◽  
P. Moser ◽  
M. Gröschl ◽  
D. Georg
Keyword(s):  
Dose Calculation ◽  
Particle Beam ◽  
Particle Beam Therapy

Analysis of the Physical and Radiobiological Equivalence of the Calculated and Measured Dose Distributions for Prostate Stereotactic Radiotherapy

2021 ◽  
Vol 66 (3) ◽  
pp. 68-75
Author(s):  
E. Sukhikh ◽  
L. Sukhikh ◽  
A. Vertinsky ◽  
P. Izhevsky ◽  
I. Sheino ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Dose Distribution ◽  
Three Dimensional ◽  
Anterior Wall ◽  
Dose Distributions ◽  
Stereotactic Radiation ◽  
Dose Volume Histograms ◽  
Dose Volume ◽  
Gamma Index ◽  
Measured Dose

Purpose: Carrying out the analysis of the physical and radiobiological equivalence of dose distributions obtained during the planning of hypofractionated stereotactic radiation therapy of the prostate cancer and verification using a three-dimensional cylindrical dosimeter. Material and Methods: Based on the anatomical data of twelve patients diagnosed with prostate carcinoma, stage T2N0M0 with low risk, plans were developed for stereotactic radiation therapy with volumetric modulates arc therapy (VMAT). The dose per fraction was 7,25 Gy for 5 fractions (total dose 36,25 Gy) with a normal photon energy of 10 MV. The developed plans were verified using a three-dimensional cylindrical ArcCHECK phantom. During the verification process, the three-dimensional dose distribution in the phantom was measured, based on which the values of the three-dimensional gamma index and the dose–volume histogram within each contoured anatomical structures were calculated with 3DVH software. The gamma index value γ (3 %, 2 mm, GN) at a threshold equal to 20 % of the dose maximum of the plan and the percentage of coincidence of points at least 95 % was chosen as a criterion of physical convergence of the calculated and measured dose distribution according to the recommendations of AAPM TG-218. To analyze the radiobiological equivalence of the calculated and measured dose distribution, the local control probability (TCP) and normal tissue complication probability (NTCP) criteria were used based on the calculated and measured dose–volume histograms. Contours of the target (PTV) and the anterior wall of the rectum were used for the analysis. The approach based on the concept of equivalent uniform dose (EUD) by A. Niemierko was used to calculate the values of TCP/NTCP criteria. Results: The results of physical convergence of plans for all patients on the contour of the whole body were higher than 95 % for the criteria γ (3 %, 2 mm, GN). The convergence along the PTV contour is in the range (75.5–95.2)%. The TCP and NTCP values obtained from the measured dose-volume histograms were higher than the planned values for all patients. It was found that the accelerator delivered a slightly higher dose to the PTV and the anterior wall of the rectum than originally planned. Conclusion: The capabilities of modern dosimetric equipment allow us move to the verification of treatment plans based on the analysis of TCP / NTCP radiobiological equivalence, taking into account the individual characteristics of the patient and the capabilities of radiation therapy equipment.

Sign in / Sign up

Export Citation Format

Share Document