Weight, Weight Gain, and Survival After Breast Cancer Diagnosis

2005 ◽  
Vol 23 (7) ◽  
pp. 1370-1378 ◽  
Author(s):  
Candyce H. Kroenke ◽  
Wendy Y. Chen ◽  
Bernard Rosner ◽  
Michelle D. Holmes
Keyword(s):  
Breast Cancer ◽  
Weight Gain ◽  
Proportional Hazards ◽  
Linear Trend ◽  
Menopausal Status ◽  
Cancer Recurrence ◽  
Cox Proportional Hazards ◽  
Breast Cancer Recurrence ◽  
Health Study ◽  
Breast Cancer Death

Purpose To determine whether weight prior to diagnosis and weight gain after diagnosis are predictive of breast cancer survival. Methods Patients included 5,204 Nurses' Health Study participants diagnosed with incident, invasive, nonmetastatic breast cancer between 1976 and 2000; 860 total deaths, 533 breast cancer deaths, and 681 recurrences (defined as secondary lung, brain, bone, or liver cancer, and death from breast cancer) accrued to 2002. We computed the change in body mass index (BMI) from before to the first BMI reported ≥ 12 months after the date of diagnosis. Cox proportional hazards models were used to evaluate associations of categories of BMI before diagnosis and of BMI change with time to event. We stratified by smoking, menopausal status, and breast cancer–related variables. Results In multivariate-adjusted analyses, weight before diagnosis was positively associated with breast cancer recurrence and death, but this was apparent only in never smokers. Similarly, among never-smoking women, those who gained between 0.5 and 2.0 kg/m2 (median gain, 6.0 lb; relative risk [RR], 1.35; 95% CI, 0.93 to 1.95) or more than 2.0 kg/m2 (median gain, 17.0 lb; RR, 1.64; 95% CI, 1.07 to 2.51) after diagnosis had an elevated risk of breast cancer death during follow-up (median, 9 years), compared with women who maintained their weight (test for linear trend, P = .03). Associations with weight were stronger in premenopausal than in postmenopausal women. Similar findings were noted for breast cancer recurrence and all-cause mortality. Conclusion Weight and weight gain were related to higher rates of breast cancer recurrence and mortality, but associations were most apparent in never-smoking women.

scholarly journals Dietary Patterns and Breast Cancer Recurrence and Survival Among Women With Early-Stage Breast Cancer

2009 ◽  
Vol 27 (6) ◽  
pp. 919-926 ◽  
Author(s):  
Marilyn L. Kwan ◽  
Erin Weltzien ◽  
Lawrence H. Kushi ◽  
Adrienne Castillo ◽  
Martha L. Slattery ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Breast Cancer Survivors ◽  
Proportional Hazards ◽  
Early Stage ◽  
Cancer Recurrence ◽  
Cox Proportional Hazards ◽  
Early Stage Breast Cancer ◽  
Breast Cancer Recurrence

Purpose To determine the association of dietary patterns with cancer recurrence and mortality of early-stage breast cancer survivors. Patients and Methods Patients included 1,901 Life After Cancer Epidemiology Study participants diagnosed with early-stage breast cancer between 1997 and 2000 and recruited primarily from the Kaiser Permanente Northern California Cancer Registry. Diet was assessed at cohort entry using a food frequency questionnaire. Two dietary patterns were identified: prudent (high intakes of fruits, vegetables, whole grains, and poultry) and Western (high intakes of red and processed meats and refined grains). Two hundred sixty-eight breast cancer recurrences and 226 all-cause deaths (128 attributable to breast cancer) were ascertained. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs. Results Increasing adherence to a prudent dietary pattern was associated with a statistically significant decreasing risk of overall death (P trend = .02; HR for highest quartile = 0.57; 95% CI, 0.36 to 0.90) and death from non–breast cancer causes (P trend = .003; HR for highest quartile = 0.35; 95% CI, 0.17 to 0.73). In contrast, increasing consumption of a Western dietary pattern was related to an increasing risk of overall death (P trend = .05) and death from non–breast cancer causes (P = .02). Neither dietary pattern was associated with risk of breast cancer recurrence or death from breast cancer. These observations were generally not modified by physical activity, being overweight, or smoking. Conclusion Women diagnosed with early-stage breast cancer might improve overall prognosis and survival by adopting more healthful dietary patterns.

scholarly journals Prevalence of Breast Cancer and Its Associated Factors for Recurrence in Hospital Tengku Ampuan Afzan 2008 – 2012

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Azhani Chik
Keyword(s):  
Breast Cancer ◽  
Multivariate Analysis ◽  
Proportional Hazards ◽  
Univariate Analysis ◽  
Cancer Recurrence ◽  
Distant Recurrence ◽  
Cox Proportional Hazards ◽  
Breast Cancer Recurrence ◽  
Local Data

Introduction: Breast cancer is the commonest malignancy in Malaysian women. Cancer recurrence has been a detrimental factor towards survival with peak of recurrence recorded in first 2 years of diagnoses. Identifying the prognostic factors towards recurrence is important to management and prolonging survival. Materials and method: We have retrospectively analyzed 179 patients women with breast cancer based on 5 years single centre database with minimum follow up of 2 years. The demographic and clinicopathological characteristics were determined using descriptive statistics. Survival were calculated based on Kaplan- Meier method and multivariate analysis by Cox proportional hazards was performed to evaluate the potential factors affecting breast cancer recurrence. Results: Mean follow up was 42 months, with mean age 52 years and 60.9% presented in Stage II disease. Overall recurrence was 41.9% with local recurrence 2.1%, regional recurrence 12.3% and distant recurrence 27.4%. 50% of our patients developed recurrence at 25 months. In univariate analysis, time to first presentation was significantly correlated with recurrence. However, in multivariate analysis; tumor size, lymph node positivity  and lymphovascular invasion were independently associated with recurrence. Conclusion: Even though local data on breast cancer recurrence is sparse, it does correlate with the international data. Thus, optimizing our care in breast cancer.

scholarly journals Menopausal status dependence of the timing of breast cancer recurrence after surgical removal of the primary tumour

2004 ◽  
Vol 6 (6) ◽  
Author(s):  
Romano Demicheli ◽  
Gianni Bonadonna ◽  
William JM Hrushesky ◽  
Michael W Retsky ◽  
Pinuccia Valagussa
Keyword(s):  
Breast Cancer ◽  
Primary Tumour ◽  
Menopausal Status ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Surgical Removal ◽  
Status Dependence

scholarly journals Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

2006 ◽  
Vol 99 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Bette J. Caan ◽  
Jennifer A. Emond ◽  
Loki Natarajan ◽  
Adrienne Castillo ◽  
Erica P. Gunderson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Weight Gain ◽  
Early Stage ◽  
Cancer Recurrence ◽  
Early Stage Breast Cancer ◽  
Breast Cancer Recurrence

Is obesity associated with increased recurrence risk in estrogen receptor (ER)-positive breast cancer?

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 171-171 ◽  
Author(s):  
K. K. L. Yap ◽  
D. N. Efiom-Ekaha
Keyword(s):  
Breast Cancer ◽  
Weight Gain ◽  
Pearson Correlation ◽  
Cancer Recurrence ◽  
Oncotype Dx ◽  
Breast Cancer Recurrence ◽  
Breast Cancers ◽  
Obese Women ◽  
Er Positive ◽  
Positive Breast Cancer

171 Background: Oncotype DX Score is a 21-gene expression analysis that has been validated clinically as a reliable predictor of breast cancer recurrence for ER-positive, node-negative breast cancers. Obesity is recognized as a risk factor for many cancers, including breast cancer. Additionally obesity has been shown to be an independent prognostic factor in breast cancer. The primary objective of this study is to determine the correlation between obesity and Oncotype DX score, hence the relationship between obesity and breast cancer recurrence in ER-positive breast cancer. The secondary objective is to investigate the association between weight gain after diagnosis and breast cancer recurrence. Methods: An IRB-exempted retrospective chart review of female patients at Wellspan Group with ER-positive breast cancer who had Oncotype DX analysis in 2008 and 2009. Data collected included Oncotype DX score and BMI (at diagnosis, 6 months and 12 months). Data were analyzed to determine the correlation between Oncotype DX score and BMI at diagnosis, at 6 months and at 12 months. The correlation between Oncotype DX score and BMI changes at 12 months also was determined. Results: A total of 125 patients were identified; 103 had BMI recorded at diagnosis, 88 had BMI recorded at 6 months and 87 had BMI recorded at 12 months. Of these, we were able to determine the BMI changes at 12 months for 82 patients. The Pearson correlation scores were 0.091 (p = 0.361), 0.074 (p = 0.492), and 0.047 (p = 0.669) for BMI at diagnosis, at 6 months and at 12 months respectively. The Pearson correlation score was 0.007 (p = 0.948) for BMI changes at 12 months. Conclusions: Obesity and weight gain are not independent predictors of recurrence in patients with ER-positive breast cancer. The reported adverse prognostic associations may be more prominent in ER-negative breast cancers. This is consistent with the reports suggesting a higher rate of ER-negative, high-grade cancers in obese women as well as a greater magnitude of benefit from dietary and weight reduction interventions seen in women with ER-negative cancers.

scholarly journals Clinical and genetic predictors of weight gain in patients diagnosed with breast cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1561-1561
Author(s):  
Sangeetha Meda Reddy ◽  
Maureen Sadim ◽  
Irene B. Helenowski ◽  
Jun Li ◽  
Nengjun Yi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Weight Gain ◽  
Cancer Patients ◽  
Menopausal Status ◽  
High Risk Patient ◽  
Cancer Recurrence ◽  
Her2 Status ◽  
Breast Cancer Patients ◽  
Mortality And Morbidity ◽  
Response To Chemotherapy

1561 Background: Obesity and weight gain in breast cancer patients has been associated with decreased quality of life, decreased response to chemotherapy, increased cancer recurrence, and higher all-cause mortality. Our study was designed to identify factors that contribute to this weight gain. Methods: Chart review was conducted on 565 breast cancer patients to obtain weights and BMIs over an 18 month period from diagnosis, tumor characteristics (ER/PR/Her2 status, grade, presence of LN metastases, stage), demographics (age, race), clinical factors (menopausal status), and treatment regimens (chemotherapy, hormone therapy, radiation). Blood samples were genotyped for polymorphisms in FTO (fat mass and obesity-associated protein) and the adiponectin pathway, two pathways found to be associated with obesity and breast cancer risk. Results: See table. For genetic analysis, one statistically significant epistatic and three gene x environmental interactions were detected for adiponectin SNPs: rs822396d x BMI at diagnosis (effect size 8.65), rs2232853a x age (2.75), rs1501299a x BMI at diagnosis (3.63), and rs266729d x rs7539542d (6.40). Conclusions: We have identified multiple clinical and genetic variables that are likely predictors of weight gain in breast cancer patients. We are conducting a prospective study of 200 breast cancer patients to validate the findings of this retrospective study. By identifying a high risk patient population, we hope to target them for aggressive lifestyle interventions to prevent weight gain and thereby improve their mortality and morbidity. [Table: see text]

scholarly journals Weight Gain, Metabolic Syndrome, and Breast Cancer Recurrence: Are Dietary Recommendations Supported by the Data?

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Colin E. Champ ◽  
Jeff S. Volek ◽  
Joshua Siglin ◽  
Lianjin Jin ◽  
Nicole L. Simone
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Weight Gain ◽  
Cancer Patients ◽  
Randomized Trials ◽  
Cancer Recurrence ◽  
Dietary Factors ◽  
Breast Cancer Recurrence ◽  
Breast Cancer Patients ◽  
Long Term Outcome

Metabolic syndrome, which can include weight gain and central obesity, elevated serum insulin and glucose, and insulin resistance, has been strongly associated with breast cancer recurrence and worse outcomes after treatment. Epidemiologic and prospective data do not show conclusive evidence as to which dietary factors may be responsible for these results. Current strategies employ low-fat diets which emphasize supplementing calories with increased intake of fruit, grain, and vegetable carbohydrate sources. Although results thus far have been inconclusive, recent randomized trials employing markedly different dietary strategies in noncancer patients may hold the key to reducing multiple risk factors in metabolic syndrome simultaneously which may prove to increase the long-term outcome of breast cancer patients and decrease recurrences. Since weight gain after breast cancer treatment confers a poor prognosis and may increase recurrence rates, large-scale randomized trials are needed to evaluate appropriate dietary interventions for our breast cancer patients.

scholarly journals No association between coffee, tea or caffeine consumption and breast cancer risk in a prospective cohort study

2011 ◽  
Vol 14 (7) ◽  
pp. 1315-1320 ◽  
Author(s):  
Guy Fagherazzi ◽  
Marina S Touillaud ◽  
Marie-Christine Boutron-Ruault ◽  
Françoise Clavel-Chapelon ◽  
Isabelle Romieu
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Proportional Hazards ◽  
Menopausal Status ◽  
Cox Proportional Hazards ◽  
Caffeine Intake ◽  
Caffeine Consumption ◽  
Receptor Status

AbstractObjectiveNumerous mechanisms for the effects of coffee, tea and caffeine on the risk of breast cancer have been suggested. Caffeine intake has already been associated with high plasma levels of female hormones, but associations have not been clearly demonstrated in epidemiological studies.DesignWe examined prospectively the association of coffee, tea and caffeine consumption with breast cancer risk in a French cohort study.SettingDietary information was obtained from a 208-item diet history questionnaire self-administered in 1993–1995. Multivariable Cox proportional hazards regression models were used to estimate hazards ratios and 95 % confidence intervals.SubjectsThe study was conducted on 67 703 women with available dietary information. During a median follow-up of 11 years, 2868 breast cancer cases were diagnosed.ResultsMedian intake was 280 ml/d (2·2 cups/d) for coffee and 214 ml/d (1·7 cups/d) for tea. Median caffeine intake was 164 mg/d. No association was found between consumption of coffee, tea or caffeine and breast cancer risk. Sub-analyses by tumour receptor status, menopausal status, type of coffee (regular or decaffeinated) and meals at which beverages were drunk led to the same conclusion.ConclusionsResults from this prospective study showed no relationship between coffee, tea or caffeine intake and breast cancer risk overall or by hormone receptor status.

Effect of Obesity on Prognosis After Early-Stage Breast Cancer

2011 ◽  
Vol 29 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Marianne Ewertz ◽  
Maj-Britt Jensen ◽  
Katrín Á. Gunnarsdóttir ◽  
Inger Højris ◽  
Erik H. Jakobsen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Adjuvant Treatment ◽  
Proportional Hazards ◽  
Early Stage ◽  
Cancer Recurrence ◽  
Distant Metastases ◽  
Cox Proportional Hazards ◽  
Early Stage Breast Cancer ◽  
The Impact

Purpose This study was performed to characterize the impact of obesity on the risk of breast cancer recurrence and death as a result of breast cancer or other causes in relation to adjuvant treatment. Patients and Methods Information on body mass index (BMI) at diagnosis was available for 18,967 (35%) of 53,816 women treated for early-stage breast cancer in Denmark between 1977 and 2006 with complete follow-up for first events (locoregional recurrences and distant metastases) up to 10 years and for death up to 30 years. Information was available on prognostic factors and adjuvant treatment for all patients. Univariate analyses were used to compare the associations of known prognostic factors and risks of recurrence or death according to BMI categories. Cox proportional hazards regression models were used to assess the influence of BMI after adjusting for other factors. Results Patients with a BMI of 30 kg/m2 or more were older and had more advanced disease at diagnosis compared with patients with a BMI below 25 kg/m2 (P < .001). When data were adjusted for disease characteristics, the risk of developing distant metastases after 10 years was significantly increased by 46%, and the risk of dying as a result of breast cancer after 30 years was significantly increased by 38% for patients with a BMI of 30 kg/m2 or more. BMI had no influence on the risk of locoregional recurrences. Both chemotherapy and endocrine therapy seemed to be less effective after 10 or more years for patients with BMIs greater than 30 kg/m2. Conclusion Obesity is an independent prognostic factor for developing distant metastases and for death as a result of breast cancer; the effects of adjuvant therapy seem to be lost more rapidly in patients with breast cancer and obesity.

β-Blockers Reduce Breast Cancer Recurrence and Breast Cancer Death: A Meta-Analysis

2015 ◽  
Vol 15 (6) ◽  
pp. 426-431 ◽  
Author(s):  
W. Kurtis Childers ◽  
Christopher S. Hollenbeak ◽  
Pramil Cheriyath
Keyword(s):  
Breast Cancer ◽  
Meta Analysis ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Cancer Death ◽  
Breast Cancer Death ◽  
Β Blockers
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