scholarly journals Menopausal status dependence of the timing of breast cancer recurrence after surgical removal of the primary tumour

2004 ◽  
Vol 6 (6) ◽  
Author(s):  
Romano Demicheli ◽  
Gianni Bonadonna ◽  
William JM Hrushesky ◽  
Michael W Retsky ◽  
Pinuccia Valagussa
Keyword(s):  
Breast Cancer ◽  
Primary Tumour ◽  
Menopausal Status ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Surgical Removal ◽  
Status Dependence

Weight, Weight Gain, and Survival After Breast Cancer Diagnosis

2005 ◽  
Vol 23 (7) ◽  
pp. 1370-1378 ◽  
Author(s):  
Candyce H. Kroenke ◽  
Wendy Y. Chen ◽  
Bernard Rosner ◽  
Michelle D. Holmes
Keyword(s):  
Breast Cancer ◽  
Weight Gain ◽  
Proportional Hazards ◽  
Linear Trend ◽  
Menopausal Status ◽  
Cancer Recurrence ◽  
Cox Proportional Hazards ◽  
Breast Cancer Recurrence ◽  
Health Study ◽  
Breast Cancer Death

Purpose To determine whether weight prior to diagnosis and weight gain after diagnosis are predictive of breast cancer survival. Methods Patients included 5,204 Nurses' Health Study participants diagnosed with incident, invasive, nonmetastatic breast cancer between 1976 and 2000; 860 total deaths, 533 breast cancer deaths, and 681 recurrences (defined as secondary lung, brain, bone, or liver cancer, and death from breast cancer) accrued to 2002. We computed the change in body mass index (BMI) from before to the first BMI reported ≥ 12 months after the date of diagnosis. Cox proportional hazards models were used to evaluate associations of categories of BMI before diagnosis and of BMI change with time to event. We stratified by smoking, menopausal status, and breast cancer–related variables. Results In multivariate-adjusted analyses, weight before diagnosis was positively associated with breast cancer recurrence and death, but this was apparent only in never smokers. Similarly, among never-smoking women, those who gained between 0.5 and 2.0 kg/m2 (median gain, 6.0 lb; relative risk [RR], 1.35; 95% CI, 0.93 to 1.95) or more than 2.0 kg/m2 (median gain, 17.0 lb; RR, 1.64; 95% CI, 1.07 to 2.51) after diagnosis had an elevated risk of breast cancer death during follow-up (median, 9 years), compared with women who maintained their weight (test for linear trend, P = .03). Associations with weight were stronger in premenopausal than in postmenopausal women. Similar findings were noted for breast cancer recurrence and all-cause mortality. Conclusion Weight and weight gain were related to higher rates of breast cancer recurrence and mortality, but associations were most apparent in never-smoking women.

scholarly journals Plasma Levels and Diagnostic Utility of VEGF in a Three-Year Follow-Up of Patients with Breast Cancer

2021 ◽  
Vol 10 (22) ◽  
pp. 5452
Author(s):  
Grażyna E. Będkowska ◽  
Ewa Gacuta ◽  
Monika Zbucka-Krętowska ◽  
Paweł Ławicki ◽  
Maciej Szmitkowski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Surgical Treatment ◽  
Plasma Concentrations ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Enzyme Linked Immunosorbent Assay ◽  
Surgical Removal ◽  
Diagnostic Utility ◽  
Combined Analysis

Breast cancer is the most common malignancy in women globally. The increasing worldwide incidence of this type of cancer illustrates the challenge it represents for healthcare providers. Therefore, new tumor markers are constantly being sought. The aim of this study was to assess plasma concentrations and the diagnostic power of VEGF in 100 patients with early-stage breast cancer, both before and after surgical treatment and during a three-year follow-up. The control groups included 50 subjects with benign breast tumors (fibroadenoma) and 50 healthy women. The VEGF concentration was determined using enzyme-linked immunosorbent assay (ELISA) and the CA 15-3 concentration was determined by chemiluminescent microparticle immunoassay (CMIA). We observed significantly higher preoperative plasma concentrations of VEGF and CA 15-3 in patients with breast cancer. VEGF, similar to CA 15-3, demonstrated high diagnostic utility in the assessment of the long-term efficacy of surgical removal of the tumor. Determinations of VEGF had the highest diagnostic usefulness in the detection of breast cancer recurrence (SE 40%, SP 92%, PPV 67%, NPV 79%). Additionally, the highest values of SE, NPV and AUC were observed during the combined analysis with CA 15-3 (60%; 84%; 0.7074, respectively). Our study suggests a promising diagnostic utility of VEGF in the early stages of breast cancer and in the evaluation of the efficacy of the surgical treatment of breast cancer as well as the detection of breast cancer recurrence, particularly in a combined analysis with CA 15-3 as a new diagnostic panel.

Postsurgical drainage and the risk of breast cancer recurrence in Chinese breast cancer patients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22234-e22234
Author(s):  
Y. Lin ◽  
W. Yin ◽  
L. Zhou ◽  
T. Yan ◽  
J. Lu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cox Regression ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Breast Cancer Surgery ◽  
Surgical Removal ◽  
Breast Cancer Patients ◽  
Kaplan Meier ◽  
Postoperative Drainage ◽  
History Of

e22234 Background: Clinical investigations suggest that while primary breast cancer surgical removal favorably modifiers the natural history of breast cancer. Postoperative drainage, a surgery-derived discharge after breast cancer surgery, reflecting some biological features of surgical stimulation, was assessed and explored its relationship with breast cancer recurrence in this study. Methods: A total of 1445 women undergoing surgery between Jan 1, 2000 and Dec31, 2002 in Cancer Hospital of Fudan University, Shanghai, China was retrospectively studied. Survival curves were performed with Kaplan-Meier method and the predictive value of postsurgical drainage was estimated using proportional Cox regression model. Conclusions: The larger drainage volume POD 1 is a useful marker, suggesting a greater stimulation to surgical treatment compared to the lower ones. Awareness of the relationship between early surgery-stimulated effects and harmful wound healing response might help to explore new strategies to block or deplete these harmful effects, resulting in improving patients' survival. No significant financial relationships to disclose.

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