Effects of Modified Low-Density Lipoproteins on Human Retinal Pericyte Survival

2005 ◽  
Vol 1043 (1) ◽  
pp. 390-395 ◽  
Author(s):  
WEIWEI SONG ◽  
JEREMY L. BARTH ◽  
KANGMO LU ◽  
YONGXIN YU ◽  
YAN HUANG ◽  
...  
Keyword(s):  
Low Density Lipoproteins ◽  
Low Density ◽  
Modified Low Density Lipoproteins

Expression of receptors for native and chemically modified low-density lipoproteins in brain microvessels

FEBS Letters ◽  
1997 ◽  
Vol 401 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Marco Lucarelli ◽  
Massimo Gennarelli ◽  
Patrizia Cardelli ◽  
Giuseppe Novelli ◽  
Sigfrido Scarpa ◽  
...  
Keyword(s):  
Low Density Lipoproteins ◽  
Low Density ◽  
Chemically Modified ◽  
Brain Microvessels ◽  
Modified Low Density Lipoproteins

Antigenic differences between apo-B in native and circulating modified low-density lipoproteins

2004 ◽  
Vol 138 (7) ◽  
pp. 42-44 ◽  
Author(s):  
I. V. Suprun ◽  
A. A. Mel’nichenko ◽  
E. V. Yanushevskaya ◽  
T. N. Vlasik ◽  
I. A. Sobenin ◽  
...  
Keyword(s):  
Low Density Lipoproteins ◽  
Low Density ◽  
Apo B ◽  
Modified Low Density Lipoproteins

scholarly journals Uptake of modified low-density lipoproteins alters actin distribution and locomotor forces in macrophages

2003 ◽  
Vol 284 (2) ◽  
pp. C555-C561 ◽  
Author(s):  
Celina V. Zerbinatti ◽  
Robert W. Gore
Keyword(s):  
Foam Cells ◽  
Force Transducer ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Force Frequency ◽  
Modified Low Density Lipoproteins ◽  
Generating Capacity ◽  
Induced Changes ◽  
Isometric Forces ◽  
Modified Forms

It is postulated that macrophage-derived foam cells accumulate in the arterial wall because they lose the ability to migrate after excessive ingestion of modified forms of low-density lipoproteins (LDL). To assess changes in locomotor force generating capacity of foam cells, we measured isometric forces in J774A.1 macrophages after cholesterol loading with oxidized (Ox-LDL) or aggregated (Agg-LDL) LDL using a novel magnetic force transducer. Ox-LDL loading reduced the ability of J774A.1 macrophages to generate isometric forces by 50% relative to control cells. Changes in force frequency consistent with reduced motility were detected as well. Agg-LDL loading was also detrimental to J774A.1 motility but to a lesser extent than Ox-LDL. Ox-LDL loading significantly reduced total actin levels and induced changes in the F-actin to G-actin distribution, whereas Agg-LDL loaded cells had significantly increased levels of total actin. These data provide evidence that cholesterol loading and subsequent accumulation decreases macrophage motility by reducing the cells' force generating capacity and that Ox-LDL appears to be more effective than Agg-LDL in disrupting the locomotor machinery.

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