scholarly journals The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

2016 ◽  
Vol 57 (6) ◽  
pp. 925-942 ◽  
Author(s):  
Aldons J. Lusis ◽  
Marcus M. Seldin ◽  
Hooman Allayee ◽  
Brian J. Bennett ◽  
Mete Civelek ◽  
...  
Keyword(s):  
Systems Genetics ◽  
Hybrid Mouse ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel ◽  
Cardiovascular Traits

scholarly journals Multidimensional Genetic Analysis of Repeated Seizures in the Hybrid Mouse Diversity Panel Reveals a Novel Epileptogenesis Susceptibility Locus

2017 ◽  
Vol 7 (8) ◽  
pp. 2545-2558 ◽  
Author(s):  
Russell J. Ferland ◽  
Jason Smith ◽  
Dominick Papandrea ◽  
Jessica Gracias ◽  
Leah Hains ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Susceptibility Locus ◽  
Hybrid Mouse ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel

scholarly journals Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

2012 ◽  
Vol 23 (9-10) ◽  
pp. 680-692 ◽  
Author(s):  
Anatole Ghazalpour ◽  
Christoph D. Rau ◽  
Charles R. Farber ◽  
Brian J. Bennett ◽  
Luz D. Orozco ◽  
...  
Keyword(s):  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Genetic Traits ◽  
Hybrid Mouse ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel

scholarly journals Extreme Phenotypic Diversity in Operant Responding for an Intravenous Cocaine or Saline Infusion in the Hybrid Mouse Diversity Panel

2021 ◽  
Author(s):  
Jared R. Bagley ◽  
Arshad H. Khan ◽  
Desmond J. Smith ◽  
James D. Jentsch
Keyword(s):  
Genetic Variants ◽  
Genomic Variation ◽  
Substantial Proportion ◽  
Genome Wide Association Studies ◽  
Self Administration ◽  
Operant Responding ◽  
Hybrid Mouse ◽  
Cocaine Use ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel

ABSTRACTCocaine self-administration is complexly determined trait, and a substantial proportion of individual differences in cocaine use is determined by genetic variation. Cocaine intravenous self-administration (IVSA) procedures in laboratory animals provide opportunities to prospectively investigate neurogenetic influences on the acquisition of voluntary cocaine use. Large and genetically diverse mouse populations, including the Hybrid Mouse Diversity Panel (HMDP), have been developed for forward genetic approaches that can reveal genetic variants that influence traits like cocaine IVSA. This population enables high resolution and well-powered genome wide association studies, as well as the discovery of genetic correlations. Here, we provide information on cocaine (or saline - as a control) IVSA in 65 strains of the HMDP. We found cocaine IVSA to be substantially heritable in this population, with strain-level intake ranging for near zero to >25 mg/kg/session. Though saline IVSA was also found to be heritable, a very modest genetic correlation between cocaine and saline IVSA indicates that operant responding for the cocaine reinforcer was influenced by a substantial proportion of unique genetic variants. These data indicate that the HMDP is suitable for forward genetic approaches for the analysis of cocaine IVSA, and this project has also led to the discovery of reference strains with extreme cocaine IVSA phenotypes, revealing them as polygenic models of risk and resilience to cocaine reinforcement. This is part of an ongoing effort to characterize genetic and genomic variation that moderates cocaine IVSA, which may, in turn, provide a more comprehensive understanding of cocaine risk genetics and neurobiology.

Diversity Council presents GLBT Diversity Panel: Don't ask, don't tell: An examination of the policy

2010 ◽  
Author(s):  
Vanessa Ewing ◽  
Joshua Brown ◽  
Gary A. Packard ◽  
William Douglas Woody
Keyword(s):  
Diversity Panel ◽  
Don't Ask Don't Tell

scholarly journals Genetic Variability, Correlation among Agronomic Traits, and Genetic Progress in a Sugarcane Diversity Panel

Agriculture ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 533
Author(s):  
Fernanda Zatti Barreto ◽  
Thiago Willian Almeida Balsalobre ◽  
Roberto Giacomini Chapola ◽  
Antonio Augusto Franco Garcia ◽  
Anete Pereira Souza ◽  
...  
Keyword(s):  
Genetic Parameters ◽  
Mixed Model ◽  
Agronomic Traits ◽  
Average Increase ◽  
Genetic Progress ◽  
Breeding Programs ◽  
Future Studies ◽  
Diversity Panel ◽  
Adjusted Means ◽  
Historical Series

Sugarcane breeding programs require 15 years of experimentation to create more productive cultivars, and estimates of genetic progress can indicate the efficiency of breeding programs. In this study, we used a diversity panel, the Brazilian Panel of Sugarcane Genotypes (BPSG), with the following objectives: (i) to estimate, through a mixed model, the adjusted means and genetic parameters of ten traits evaluated over three harvest years; (ii) to estimate genotypic correlation among those traits; and (iii) to estimate genetic progress over six decades of breeding. The heritabilities ranged from 0.43 to 0.88, and we detected 42 significant correlations, 9 negative and 33 positive. Over six decades, the sucrose-related traits BRIX, POL%C, and POL%J showed an average increase per decade of 0.27 °Brix (0.26% and 0.31%, respectively). Stalk number, height, and weight of the plot, and cane and sucrose yields revealed average increases per decade of 3.27 stalks, 0.06 m, 9.42 kg, 11.22 t/ha, and 2.08 t/ha, respectively. The genetic progress of the main agronomic traits is discussed through a historical series of sugarcane genotypes present in the BPSG. The findings of this study could contribute to the management of new breeding strategies and allow for future studies of associative mapping.

scholarly journals Population genomics and haplotype analysis in spelt and bread wheat identifies a gene regulating glume color

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Michael Abrouk ◽  
Naveenkumar Athiyannan ◽  
Thomas Müller ◽  
Yveline Pailles ◽  
Christoph Stritt ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Candidate Gene ◽  
Population Genomics ◽  
Genotyping By Sequencing ◽  
Wheat Cultivars ◽  
Structural Variations ◽  
High Quality ◽  
Diversity Panel ◽  
Haplotype Variation ◽  
Single Region

AbstractThe cloning of agriculturally important genes is often complicated by haplotype variation across crop cultivars. Access to pan-genome information greatly facilitates the assessment of structural variations and rapid candidate gene identification. Here, we identified the red glume 1 (Rg-B1) gene using association genetics and haplotype analyses in ten reference grade wheat genomes. Glume color is an important trait to characterize wheat cultivars. Red glumes are frequent among Central European spelt, a dominant wheat subspecies in Europe before the 20th century. We used genotyping-by-sequencing to characterize a global diversity panel of 267 spelt accessions, which provided evidence for two independent introductions of spelt into Europe. A single region at the Rg-B1 locus on chromosome 1BS was associated with glume color in the diversity panel. Haplotype comparisons across ten high-quality wheat genomes revealed a MYB transcription factor as candidate gene. We found extensive haplotype variation across the ten cultivars, with a particular group of MYB alleles that was conserved in red glume wheat cultivars. Genetic mapping and transient infiltration experiments allowed us to validate this particular MYB transcription factor variants. Our study demonstrates the value of multiple high-quality genomes to rapidly resolve copy number and haplotype variations in regions controlling agriculturally important traits.

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