scholarly journals Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2′-O-Methoxyethyl Antisense Oligonucleotide

2019 ◽  
Vol 29 (5) ◽  
pp. 266-277
Author(s):  
Elaine Pirie ◽  
Patrick Cauntay ◽  
Wuxia Fu ◽  
Shayoni Ray ◽  
Calvin Pan ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Antisense Oligonucleotide ◽  
Genetic Architecture ◽  
Hybrid Mouse ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel

scholarly journals Multidimensional Genetic Analysis of Repeated Seizures in the Hybrid Mouse Diversity Panel Reveals a Novel Epileptogenesis Susceptibility Locus

2017 ◽  
Vol 7 (8) ◽  
pp. 2545-2558 ◽  
Author(s):  
Russell J. Ferland ◽  
Jason Smith ◽  
Dominick Papandrea ◽  
Jessica Gracias ◽  
Leah Hains ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Susceptibility Locus ◽  
Hybrid Mouse ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel

scholarly journals Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

2012 ◽  
Vol 23 (9-10) ◽  
pp. 680-692 ◽  
Author(s):  
Anatole Ghazalpour ◽  
Christoph D. Rau ◽  
Charles R. Farber ◽  
Brian J. Bennett ◽  
Luz D. Orozco ◽  
...  
Keyword(s):  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Genetic Traits ◽  
Hybrid Mouse ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel

scholarly journals The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

2016 ◽  
Vol 57 (6) ◽  
pp. 925-942 ◽  
Author(s):  
Aldons J. Lusis ◽  
Marcus M. Seldin ◽  
Hooman Allayee ◽  
Brian J. Bennett ◽  
Mete Civelek ◽  
...  
Keyword(s):  
Systems Genetics ◽  
Hybrid Mouse ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel ◽  
Cardiovascular Traits

scholarly journals Extreme Phenotypic Diversity in Operant Responding for an Intravenous Cocaine or Saline Infusion in the Hybrid Mouse Diversity Panel

2021 ◽  
Author(s):  
Jared R. Bagley ◽  
Arshad H. Khan ◽  
Desmond J. Smith ◽  
James D. Jentsch
Keyword(s):  
Genetic Variants ◽  
Genomic Variation ◽  
Substantial Proportion ◽  
Genome Wide Association Studies ◽  
Self Administration ◽  
Operant Responding ◽  
Hybrid Mouse ◽  
Cocaine Use ◽  
Diversity Panel ◽  
Hybrid Mouse Diversity Panel

ABSTRACTCocaine self-administration is complexly determined trait, and a substantial proportion of individual differences in cocaine use is determined by genetic variation. Cocaine intravenous self-administration (IVSA) procedures in laboratory animals provide opportunities to prospectively investigate neurogenetic influences on the acquisition of voluntary cocaine use. Large and genetically diverse mouse populations, including the Hybrid Mouse Diversity Panel (HMDP), have been developed for forward genetic approaches that can reveal genetic variants that influence traits like cocaine IVSA. This population enables high resolution and well-powered genome wide association studies, as well as the discovery of genetic correlations. Here, we provide information on cocaine (or saline - as a control) IVSA in 65 strains of the HMDP. We found cocaine IVSA to be substantially heritable in this population, with strain-level intake ranging for near zero to >25 mg/kg/session. Though saline IVSA was also found to be heritable, a very modest genetic correlation between cocaine and saline IVSA indicates that operant responding for the cocaine reinforcer was influenced by a substantial proportion of unique genetic variants. These data indicate that the HMDP is suitable for forward genetic approaches for the analysis of cocaine IVSA, and this project has also led to the discovery of reference strains with extreme cocaine IVSA phenotypes, revealing them as polygenic models of risk and resilience to cocaine reinforcement. This is part of an ongoing effort to characterize genetic and genomic variation that moderates cocaine IVSA, which may, in turn, provide a more comprehensive understanding of cocaine risk genetics and neurobiology.

Genetic architecture of yellow and stem rust resistance in a durum wheat diversity panel

Euphytica ◽  
2019 ◽  
Vol 215 (4) ◽  
Author(s):  
Thomas Miedaner ◽  
Matthias Rapp ◽  
Kerstin Flath ◽  
C. Friedrich H. Longin ◽  
Tobias Würschum
Keyword(s):  
Durum Wheat ◽  
Stem Rust ◽  
Genetic Architecture ◽  
Rust Resistance ◽  
Stem Rust Resistance ◽  
Diversity Panel

scholarly journals Genetic Architecture of Flooding Tolerance in the Dry Bean Middle-American Diversity Panel

2017 ◽  
Vol 8 ◽  
Author(s):  
Ali Soltani ◽  
Samira MafiMoghaddam ◽  
Katelynn Walter ◽  
Daniel Restrepo-Montoya ◽  
Sujan Mamidi ◽  
...  
Keyword(s):  
Genetic Architecture ◽  
Flooding Tolerance ◽  
Dry Bean ◽  
Diversity Panel

scholarly journals Advances in comparative genetics: influence of genetics on obesity

2011 ◽  
Vol 106 (S1) ◽  
pp. S1-S10 ◽  
Author(s):  
Wendy Foulds Mathes ◽  
Scott A. Kelly ◽  
Daniel Pomp
Keyword(s):  
Mouse Models ◽  
Biological Networks ◽  
Genetic Architecture ◽  
Inbred Strains ◽  
Individual Variability ◽  
Voluntary Exercise ◽  
Fat Percentage ◽  
Complex Interactions ◽  
Component Traits ◽  
Hybrid Mouse Diversity Panel

Obesity has reached epidemic proportions and is recognised as a significant global health problem. Increased food intake and decreased physical activity are traditionally to blame for the development of obesity; however, many variables such as behaviour, diet, environment, social structures and genetics also contribute to this multifactorial disease. Complex interactions among these variables (for example, gene–environment, gene–diet and gene–gene) contribute not only to individual differences in the development of obesity, but also in treatment response. Mouse models have historically played valuable roles in understanding the genetics of traits related to energy balance and obesity. In the present review, we survey past use and examine new advances in mouse models designed to uncover the genetic architecture of obesity and its component traits. We discuss traditional models such as inbred strains and selectively bred lines and their contributions and shortcomings. We consider the evolution of mouse models into more informative resources such as outbred crosses and the Hybrid Mouse Diversity Panel, as well as novel next-generation approaches such as the Collaborative Cross. Moreover, the genetic architecture of voluntary exercise and the interactive relationship between host genetics and the gut microbiome are presented as novel phenotypes that augment studies using body weight and body fat percentage as endpoints. Understanding the intricate network of phenotypic, genotypic and environmental variables that predispose individuals to obesity will elucidate biological networks involved in the development of obesity. Knowledge obtained from advances in mouse models will inform human health and provide insight into inter-individual variability in the aetiology of obesity-related diseases.

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