scholarly journals Aspirin alone and combined with a statin suppresses eicosanoid formation in human colon tissue

2018 ◽  
Vol 59 (5) ◽  
pp. 864-871 ◽  
Author(s):  
Heike Gottschall ◽  
Christoph Schmöcker ◽  
Dirk Hartmann ◽  
Nadine Rohwer ◽  
Katharina Rund ◽  
...  
Keyword(s):  
Human Colon ◽  
Colon Tissue ◽  
Eicosanoid Formation

Evaluation of ultrasound and glucose synergy effect on the optical clearing and light penetration for human colon tissue using SD-OCT

2014 ◽  
Vol 7 (11-12) ◽  
pp. 938-947 ◽  
Author(s):  
Qingliang Zhao ◽  
Huajiang Wei ◽  
Yonghong He ◽  
Qiushi Ren ◽  
Chuanqing Zhou
Keyword(s):  
Human Colon ◽  
Light Penetration ◽  
Synergy Effect ◽  
Colon Tissue ◽  
Optical Clearing ◽  
Sd Oct

scholarly journals Colonic Saturated Fatty Acid Concentrations and Expression of COX-1, but not Diet, Predict Prostaglandin E2in Normal Human Colon Tissue

2016 ◽  
Vol 68 (7) ◽  
pp. 1192-1201 ◽  
Author(s):  
ElKhansa Sidahmed ◽  
Ananda Sen ◽  
Jianwei Ren ◽  
Arsh Patel ◽  
D. Kim Turgeon ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Saturated Fatty Acid ◽  
Human Colon ◽  
Colon Tissue ◽  
Normal Human ◽  
Cox 1

scholarly journals Label-free quantitative optical assessment of human colon tissue using spatial frequency domain imaging

2018 ◽  
Vol 22 (8) ◽  
pp. 617-621 ◽  
Author(s):  
S. Nandy ◽  
W. Chapman ◽  
R. Rais ◽  
I. González ◽  
D. Chatterjee ◽  
...  
Keyword(s):  
Spatial Frequency ◽  
Frequency Domain ◽  
Human Colon ◽  
Label Free ◽  
Colon Tissue ◽  
Spatial Frequency Domain Imaging ◽  
Spatial Frequency Domain

Abstract 657: The comparison of calcium-induced differentiation in colonoid cultures derived from the normal human colon tissue and colonic adenomas

2019 ◽  
Author(s):  
Muhammad N. Aslam ◽  
Shannon D. McClintock ◽  
Areeba H. Rizvi ◽  
Durga Attili ◽  
Shailja Pandya ◽  
...  
Keyword(s):  
Human Colon ◽  
Colon Tissue ◽  
Induced Differentiation ◽  
Colonic Adenomas ◽  
Normal Human

scholarly journals Zinc Phthalocyanine Photochemistry by Raman Imaging, Fluorescence Spectroscopy and Femtosecond Spectroscopy in Normal and Cancerous Human Colon Tissues and Single Cells

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2688 ◽  
Author(s):  
Beata Brozek-Pluska ◽  
Arkadiusz Jarota ◽  
Rafal Kania ◽  
Halina Abramczyk
Keyword(s):  
Single Cells ◽  
Blue Shift ◽  
Human Colon ◽  
Raman Imaging ◽  
Zinc Phthalocyanine ◽  
Label Free ◽  
Colon Tissue ◽  
Tissue Samples ◽  
Colon Cells ◽  
Normal Human

Photodynamic therapy is a clinically approved alternative method for cancer treatment in which a combination of nontoxic drugs known as photosensitizers and oxygen is used. Despite intensive investigations and encouraging results, zinc phthalocyanines (ZnPcs) have not yet been approved as photosensitizers for clinical use. Label-free Raman imaging of nonfixed and unstained normal and cancerous colon human tissues and normal human CCD18-Co and cancerous CaCo-2 cell lines, without and after adding ZnPcS4 photosensitizer, was analyzed. The biochemical composition of normal and cancerous colon tissues and colon cells without and after adding ZnPcS4 at the subcellular level was determined. Analyzing the fluorescence/Raman signals of ZnPcS4, we found that in normal human colon tissue samples, in contrast to cancerous ones, there is a lower affinity to ZnPcS4 phthalocyanine. Moreover, a higher concentration in cancerous tissue was concomitant with a blue shift of the maximum peak position specific for the photosensitizer from 691–695 nm to 689 nm. Simultaneously for both types of samples, the signal was observed in the monomer region, confirming the excellent properties of ZnPcS4 for photo therapy (PDT). For colon cell experiments with a lower concentration of ZnPcS4 photosensitizer, c = 1 × 10−6 M, the phthalocyanine was localized in mitochondria/lipid structures; for a higher concentration, c = 9 × 10−6 M, localization inside the nucleus was predominant. Based on time-resolved experiments, we found that ZnPcS4 in the presence of biological interfaces features longer excited-state lifetime photosensitizers compared to the aqueous solution and bare ZnPcS4 film on CaF2 substrate, which is beneficial for application in PDT.

Glutathione S-transferases in noral and malignant human colon tissue

1991 ◽  
Vol 1096 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Margie L. Clapper ◽  
Sandra J. Hoffman ◽  
Kenneth D. Tew
Keyword(s):  
Human Colon ◽  
Colon Tissue ◽  
Glutathione S Transferases
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