scholarly journals Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration

2017 ◽  
Vol 58 (9) ◽  
pp. 1785-1796 ◽  
Author(s):  
Chui Ming Gemmy Cheung ◽  
Alfred Gan ◽  
Qiao Fan ◽  
Miao Ling Chee ◽  
Rajendra S. Apte ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Plasma Lipoprotein ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Lipoprotein Subfraction

The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration

2019 ◽  
pp. 47-71
Author(s):  
Christopher Fortenbach ◽  
Elissa Goldman ◽  
Amar U. Kishan ◽  
Shilpa Mathew ◽  
Bobeck S. Modjtahedi ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

Changes in lipid metabolism in women with age-related macular degeneration

2005 ◽  
Vol 4 (4) ◽  
pp. 183-187 ◽  
Author(s):  
M. Nowak ◽  
E. Swietochowska ◽  
B. Marek ◽  
B. Szapska ◽  
T. Wielkoszynski ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Norihiro Nagai ◽  
Hirohiko Kawashima ◽  
Eriko Toda ◽  
Kohei Homma ◽  
Hideto Osada ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Renin Angiotensin System ◽  
Age Related Macular Degeneration ◽  
Photoreceptor Outer Segment ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Age Related

AbstractMetabolic syndrome, a condition involving obesity and hypertension, increases the risk of aging-associated diseases such as age-related macular degeneration (AMD). Here, we demonstrated that high-fat diet (HFD)-fed mice accumulated oxidized low-density lipoprotein (ox-LDL) in macrophages through the renin–angiotensin system (RAS). The ox-LDL-loaded macrophages were responsible for visual impairment in HFD mice along with a disorder of the retinal pigment epithelium (RPE), which is required for photoreceptor outer segment renewal. RAS repressed ELAVL1, which reduced PPARγ, impeding ABCA1 induction to levels that are sufficient to excrete overloaded cholesterol within the macrophages. The ox-LDL-loaded macrophages expressed inflammatory cytokines and attacked the RPE. An antihypertensive drug, angiotensin II type 1 receptor (AT1R) blocker, resolved the decompensation of lipid metabolism in the macrophages and reversed the RPE condition and visual function in HFD mice. AT1R signaling could be a future therapeutic target for macrophage-associated aging diseases, such as AMD.

New insight into the genetics of age-related macular degeneration in connection with lipid metabolism

2010 ◽  
Vol 5 (1) ◽  
pp. 15-18
Author(s):  
Lionel Bretillon ◽  
Niyazi Acar ◽  
Alain Bron ◽  
Catherine Creuzot-Garcher
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Insight Into

Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

2001 ◽  
Vol 58 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Ursula Körner-Stiefbold
Keyword(s):  
Macular Degeneration ◽  
Clinical Features ◽  
Altersbedingte Makuladegeneration ◽  
Age Related Macular Degeneration ◽  
Genetische Faktoren ◽  
Age Related ◽  
Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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