scholarly journals Hepatic deletion of X-box binding protein 1 impairs bile acid metabolism in mice

2016 ◽  
Vol 58 (3) ◽  
pp. 504-511 ◽  
Author(s):  
Xiaoying Liu ◽  
Anne S. Henkel ◽  
Brian E. LeCuyer ◽  
Susan C. Hubchak ◽  
Matthew J. Schipma ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Binding Protein ◽  
Bile Acid Metabolism

scholarly journals RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism

2017 ◽  
Vol 127 (10) ◽  
pp. 3741-3754 ◽  
Author(s):  
Elizabeth J. Tarling ◽  
Bethan L. Clifford ◽  
Joan Cheng ◽  
Pauline Morand ◽  
Angela Cheng ◽  
...  
Keyword(s):  
Bile Acid ◽  
Posttranscriptional Regulation ◽  
Acid Metabolism ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Bile Acid Metabolism

Abstract 402: Post-transcriptional Regulation of Bile Acid Metabolism by the RNA binding protein ZFP36L1

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Elizabeth Tarling ◽  
Joan Cheng ◽  
Angela Cheng ◽  
Pauline Morand ◽  
Bethan Clifford ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Acid Metabolism ◽  
Rna Binding ◽  
Binding Protein ◽  
Plasma Cholesterol ◽  
Rna Binding Protein ◽  
Lipid Absorption ◽  
Bile Acid Metabolism ◽  
Mrna Levels

Bile acids are detergents and important signaling molecules that activate the nuclear receptor FXR to control key metabolic processes, including feedback mechanisms to maintain bile acid homeostasis. Activation of FXR decreases the mRNA levels of several bile acid synthetic genes, including the rate-limiting enzyme Cyp7a1 . Here we show that Cyp7a1 mRNA levels are very rapidly reduced following FXR activation, indicative of a post-transcriptional mechanism. We identify the RNA binding protein Zfp36l1 as an FXR target gene and show that hepatic overexpression of ZFP36L1 in mice decreases Cyp7a1 mRNA levels. In contrast, Zfp36l1 L -KO mice have increased levels of Cyp7a1 mRNA and biliary bile acids as well as reduced plasma cholesterol levels. Zfp36l1 L -KO mice fed a Western diet have reduced diet-induced obesity and steatosis, likely due to impaired lipid absorption, consistent with increased Cyp7a1 levels. Thus, the ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor of dyslipidemia, obesity and hepatosteatosis.

T cell mediated cholangitis alters bile acid metabolism

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
F Glaser ◽  
C John ◽  
B Engel ◽  
B Höh ◽  
S Weidemann ◽  
...  
Keyword(s):  
Bile Acid ◽  
T Cell ◽  
Acid Metabolism ◽  
Bile Acid Metabolism

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy through regulation of gut microbiota and bile acid metabolism

2021 ◽  
Author(s):  
Ming-zhi Zhu ◽  
Fang Zhou ◽  
Jian Ouyang ◽  
Qi-ye Wang ◽  
Yi-long Li ◽  
...  
Keyword(s):  
Bile Acid ◽  
Synergistic Effect ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Low Doses ◽  
Combined Use

Combined use of epigallocatechin-3-gallate (EGCG) and caffeine in low doses exhibits marked anti-obesity synergy. The synergistic effect may be attributed to regulation of gut microbiota and BA metabolism.

scholarly journals STUDIES ON BILE ACID METABOLISM

1942 ◽  
Vol 143 (3) ◽  
pp. 771-783
Author(s):  
L.H. Schmidt ◽  
Hettie B. Hughes
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Bile Acid Metabolism
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