scholarly journals Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion

2015 ◽  
Vol 56 (7) ◽  
pp. 1296-1307 ◽  
Author(s):  
Yan Wang ◽  
Viktoria Gusarova ◽  
Serena Banfi ◽  
Jesper Gromada ◽  
Jonathan C. Cohen ◽  
...  
Keyword(s):  
Triglyceride Secretion ◽  
Vldl Triglyceride

scholarly journals Central Nervous System Neuropeptide Y Signaling Modulates VLDL Triglyceride Secretion

Diabetes ◽  
2008 ◽  
Vol 57 (6) ◽  
pp. 1482-1490 ◽  
Author(s):  
J. M. Stafford ◽  
F. Yu ◽  
R. Printz ◽  
A. H. Hasty ◽  
L. L. Swift ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuropeptide Y ◽  
Triglyceride Secretion ◽  
Vldl Triglyceride

scholarly journals ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein inob/obmice

2008 ◽  
Vol 49 (9) ◽  
pp. 2013-2022 ◽  
Author(s):  
Zhouji Chen ◽  
Elizabeth P. Newberry ◽  
Jin Y. Norris ◽  
Yan Xie ◽  
Jianyang Luo ◽  
...  
Keyword(s):  
Microsomal Triglyceride Transfer Protein ◽  
Transfer Protein ◽  
Triglyceride Secretion ◽  
Vldl Triglyceride

scholarly journals Biogenesis of apolipoprotein A-V and its impact on VLDL triglyceride secretion

2010 ◽  
Vol 52 (2) ◽  
pp. 237-244 ◽  
Author(s):  
Anna M. Blade ◽  
Melissa A. Fabritius ◽  
Li Hou ◽  
Richard B. Weinberg ◽  
Gregory S. Shelness
Keyword(s):  
Apolipoprotein A ◽  
Triglyceride Secretion ◽  
Vldl Triglyceride

scholarly journals Altered plasma triglyceride-rich lipoproteins and triglyceride secretion in feed-restricted pregnant ewes

2009 ◽  
Vol 54 (No. 9) ◽  
pp. 412-418 ◽  
Author(s):  
A. Mazur ◽  
M. Ozgo ◽  
Y. Rayssiguier
Keyword(s):  
Fatty Infiltration ◽  
Plasma Concentrations ◽  
Density Lipoprotein ◽  
Late Pregnancy ◽  
Plasma Free Fatty Acid ◽  
Feed Restriction ◽  
Adequate Diet ◽  
Triglyceride Secretion ◽  
Vldl Triglyceride ◽  
Secretion Rates

In late pregnancy, energy deficits in ewes can induce a metabolic imbalance, which often results in pregnancy toxaemia. This metabolic disorder is characterised by hypoglycaemia, hyperketonaemia, an increase in plasma concentrations of free fatty acids and by fatty infiltration in the liver. The purpose of the present study was to identify alterations in lipid and triglyceride-rich lipoprotein distribution and to evaluate triglyceride secretion in ewes during the third trimester of pregnancy, particularly in ewes with feed restriction. The study was performed on non-pregnant and on twin- and triplet-bearing pregnant Limousine × Romanov ewes fed a control or restricted diet. We show that in pregnant ewes, feed restriction resulted in strong lipomobilisation, as monitored by high plasma free fatty acid concentration, and in hypoglycaemia and hyperketonaemia. Plasma and very low density lipoprotein (VLDL) triglyceride concentrations were about four-fold higher in adequately-fed pregnant ewes than in non-pregnant ewes. Feed restriction in pregnant ewes resulted in VLDL triglyceride concentrations that were approximately two-thirds lower than in adequately-fed pregnant ewes. VLDL particles from pregnant ewes were found to be enriched in triglycerides, but to a lesser extent in feed-restricted pregnant ewes. Pregnant ewes that were fed an adequate diet exhibited greater triglyceride secretion rates (TGSR) than non-pregnant ewes. Feed restriction in pregnant ewes resulted in triglyceride secretion rates that were approximately 35% lower than those of pregnant ewes fed an adequate diet. Our results support the idea that exacerbated lipomobilisation in late pregnancy leads to profound lipid and lipoprotein metabolism disturbances.

scholarly journals A novel role for ABCA1-generated large pre-β migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion

2009 ◽  
Vol 51 (4) ◽  
pp. 729-742 ◽  
Author(s):  
Soonkyu Chung ◽  
Abraham K. Gebre ◽  
Jeongmin Seo ◽  
Gregory S. Shelness ◽  
John S. Parks
Keyword(s):  
Triglyceride Secretion ◽  
Vldl Triglyceride

scholarly journals Increased VLDL-Triglyceride Secretion Precedes Impaired Control of Endogenous Glucose Production in Obese, Normoglycemic Men

Diabetes ◽  
2011 ◽  
Vol 60 (9) ◽  
pp. 2257-2264 ◽  
Author(s):  
L. P. Sorensen ◽  
E. Sondergaard ◽  
B. Nellemann ◽  
J. S. Christiansen ◽  
L. C. Gormsen ◽  
...  
Keyword(s):  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Triglyceride Secretion ◽  
Impaired Control ◽  
Endogenous Glucose ◽  
Vldl Triglyceride

scholarly journals Hepatic Fatty Acid Balance and Hepatic Fat Content in Humans With Severe Obesity

2019 ◽  
Vol 104 (12) ◽  
pp. 6171-6181 ◽  
Author(s):  
Kelli A Lytle ◽  
Nikki C Bush ◽  
Jessica M Triay ◽  
Todd A Kellogg ◽  
Michael L Kendrick ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Liver ◽  
Severe Obesity ◽  
Acid Oxidation ◽  
Hepatic Fatty Acid ◽  
Triglyceride Secretion ◽  
Hepatic Fatty Acid Oxidation ◽  
Vldl Triglyceride ◽  
Secretion Rates

Abstract Objective Nonalcoholic fatty liver disease can lead to hepatic inflammation/damage. Understanding the physiological mechanisms that contribute to excess hepatic lipid accumulation may help identify effective treatments. Design We recruited 25 nondiabetic patients with severe obesity scheduled for bariatric surgery. To evaluate liver export of triglyceride fatty acids, we measured very-low-density lipoprotein (VLDL)–triglyceride secretion rates the day prior to surgery using an infusion of autologous [1-14C]triolein-labeled VLDL particles. Ketone body response to fasting and intrahepatic long-chain acylcarnitine concentrations were used as indices of hepatic fatty acid oxidation. We measured intraoperative hepatic uptake rates of plasma free fatty acids using a continuous infusion of [U-13C]palmitate, combined with a bolus dose of [9,10-3H]palmitate and carefully timed liver biopsies. Total intrahepatic lipids were measured in liver biopsy samples to determine fatty liver status. The hepatic concentrations and enrichment from [U-13C]palmitate in diacylglycerols, sphingolipids, and acyl-carnitines were measured using liquid chromatography/tandem mass spectrometry. Results Among study participants with fatty liver disease, intrahepatic lipid was negatively correlated with VLDL-triglyceride secretion rates (r = −0.92, P = 0.01) but unrelated to hepatic free fatty acid uptake or indices of hepatic fatty acid oxidation. VLDL-triglyceride secretion rates were positively correlated with hepatic concentrations of saturated diacylglycerol (r = 0.46, P = 0.02) and sphingosine-1-phosphate (r = 0.44, P = 0.03). Conclusion We conclude that in nondiabetic humans with severe obesity, excess intrahepatic lipid is associated with limited export of triglyceride in VLDL particles rather than increased uptake of systemic free fatty acids.

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