scholarly journals Quantification of muscle triglyceride synthesis rate requires an adjustment for total triglyceride content

2018 ◽  
Vol 59 (10) ◽  
pp. 2018-2024 ◽  
Author(s):  
Rabia Asghar ◽  
Maria Chondronikola ◽  
Edgar L. Dillon ◽  
William J. Durham ◽  
Craig Porter ◽  
...  
Keyword(s):  
Synthesis Rate ◽  
Triglyceride Synthesis ◽  
Triglyceride Content ◽  
Muscle Triglyceride ◽  
Total Triglyceride

scholarly journals Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Takashi Nakamura ◽  
Mai Nampei ◽  
Takayo Murase ◽  
Etsuko Satoh ◽  
Seigo Akari ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Ketone Body ◽  
The Body ◽  
Xanthine Oxidoreductase ◽  
Diabetic Mellitus ◽  
Triglyceride Content ◽  
Xanthine Oxidoreductase Inhibitor ◽  
Single Regression ◽  
Muscle Triglyceride

AbstractPlasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed standard diets with or without topiroxostat for 4 weeks. Body weight and food intake were constantly monitored, along with monitoring plasma biochemical markers, including insulin and XOR activity. Additionally, hepatic hypoxanthine and XOR activity were also documented. Single regression analysis was performed to determine the mechanism. Topiroxostat treatment suppressed weight gain relative to the vehicle without any impact on food intake. However, the weight of fat pads and hepatic and muscle triglyceride content did not change. Topiroxostat decreased the plasma uric acid and increased hepatic hypoxanthine in response to the inhibition of XOR activity. Plasma ketone body and free fatty acid were also increased. Moreover, fat weight was weakly associated with plasma XOR activity in the diabetic state and was negatively associated with ketone body by topiroxostat. These results suggested that topiroxostat amplified the burning of lipids and the salvage pathway, resulting in predisposing the body toward catabolism. The inhibition of plasma XOR activity may contribute to weight loss.

scholarly journals The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

Diabetes ◽  
2002 ◽  
Vol 51 (3) ◽  
pp. 797-802 ◽  
Author(s):  
A. B. Mayerson ◽  
R. S. Hundal ◽  
S. Dufour ◽  
V. Lebon ◽  
D. Befroy ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Triglyceride Content ◽  
Muscle Triglyceride

scholarly journals mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

2016 ◽  
Vol 5 (8) ◽  
pp. 646-655 ◽  
Author(s):  
Maximilian Kleinert ◽  
Benjamin L. Parker ◽  
Rima Chaudhuri ◽  
Daniel J. Fazakerley ◽  
Annette Serup ◽  
...  
Keyword(s):  
Triglyceride Content ◽  
Muscle Triglyceride

Effects of life-long exercise on circulating free fatty acids and muscle triglyceride content in ageing rats

2004 ◽  
Vol 39 (9) ◽  
pp. 1333-1340 ◽  
Author(s):  
Michela Novelli ◽  
Alessandro Pocai ◽  
Monika Skalicky ◽  
Andrus Viidik ◽  
Ettore Bergamini ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Triglyceride Content ◽  
Muscle Triglyceride
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