scholarly journals Monitoring of patients on high dose antipsychotic medication

1997 ◽  
Vol 21 (10) ◽  
pp. 612-614 ◽  
Author(s):  
Kate Sillifant ◽  
Jacqueline Muir ◽  
Mary Crabb ◽  
Stephen Read
Keyword(s):  
Learning Disabilities ◽  
Liver Function ◽  
Antipsychotic Medication ◽  
Royal College ◽  
Liver Function Tests ◽  
High Dose ◽  
Essentially Normal ◽  
Cell Counts ◽  
Routine Monitoring ◽  
Mild Anaemia

In the light of recently published Royal College of Psychiatrists' guidelines on the use of high dose antipsychotic medication, electrocardiographic and blood investigations were performed on 11 patients with learning disabilities receiving such treatment. All patients had normal electrocardiograms (ECGs). Four patients had asymptomatic low white cell counts and mild anaemia was detected in three individuals. Three patients were hyponatraemic; liver function tests were essentially normal. Issues around routine monitoring of such patients are discussed.

The oral α and β tubulin inhibitor, VERU-111, for the treatment of metastatic castration-resistant and androgen blocking agent-resistant prostate cancer in nonclinical toxicity studies.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 299-299
Author(s):  
Robert H. Getzenberg ◽  
Mario A. Eisenberger ◽  
Mark Christopher Markowski ◽  
Gary Barnette ◽  
Darryl Patrick ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Liver Function ◽  
Liver Function Tests ◽  
Blocking Agent ◽  
Resistance Mechanisms ◽  
Multi Drug Resistance ◽  
High Dose ◽  
Tubulin Inhibitor ◽  
Toxicity Studies ◽  
Taxane Chemotherapy

299 Background: A dose limiting toxicity of taxane chemotherapy, including docetaxel and cabazitaxel, is neutropenia. VERU-111 is a novel, oral aand btubulin inhibitor that blocks tubulin polymerization and is not a substrate for multi-drug resistance mechanisms. Nonclinical toxicity studies were recently performed in order to assess the effects of daily, high-dose administration of orally dosed daily VERU-111. Methods: Toxicity of VERU-111 was evaluated in a 28-day oral dosing toxicity study which was conducted in both rats and dogs. These studies were performed at an independent facility under GLP conditions. Results: In both species evaluated, at oral doses of ≤3 mg/kg/day (rat) and ≤8 mg/kg/day (dog) there were no significant observed findings of neutropenia, myelosuppression, or abnormal liver function. Conclusions: In contrast to cabazitaxel and docetaxel, which are given once every 3 weeks IV, VERU-111 given oral, daily for 28 days in toxicity studies in dog and rat did not result in neutropenia, and myelosuppression. Furthermore, VERU-111 orally each day did not affect liver function tests. These nonclinical toxicity studies provide the basis for progressing VERU-111 into a Phase 1b/2 study which targets men with metastatic castration and androgen blocking agent (abiraterone and enzalutamide) resistant prostate cancer.

Effect of High Dose Acetaminophen on Liver Function Tests in Healthy Subjects

2017 ◽  
Vol 39 (8) ◽  
pp. e5-e6
Author(s):  
Y. Kumagai ◽  
I.D. Song ◽  
M. Maeda ◽  
R. Tanaka ◽  
Y. Sakamoto ◽  
...  
Keyword(s):  
Liver Function ◽  
Healthy Subjects ◽  
Liver Function Tests ◽  
High Dose ◽  
Function Tests

scholarly journals Assessment of Plasma Homocysteine in Acne Patients isotretinoim Therapy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Sallam ◽  
K M A Alzawahry ◽  
R M Z Haki
Keyword(s):  
Side Effects ◽  
Liver Function ◽  
Lipid Profile ◽  
Low Dose ◽  
Homocysteine Level ◽  
Liver Function Tests ◽  
High Dose ◽  
Severe Acne ◽  
Function Tests ◽  
Significant Difference

Abstract Background Acne is a chronic inflammatory disorder of the pilosebaceous unit. Oral isotretinoin is a highly effective treatment for patients with moderate and severe, but causes significant side effects. Objective To estimate homocysteine level in acne patients after treatment with isotretinoin. Patients and Methods The prospective study was conducted at Ain Shams University Faculty of Medicine, Egypt, from June 2017 to November 2017, including male or non-pregnant female patients more than 18 years of age, categorized by the Global Evaluation Acne (GEA) into 22 patients with moderate acne vulgaris and 22 patients with severe acne. Isotretinoin was started in a dosage of 0.5 mg/kg/day, and 1.0mg/kg/day in moderate and severe acne patients respectively. Baseline homocysteine level, liver function tests, serum cholesterol and lipid profile were tested before and after 3 months. Results There was significant difference (p = 0.001) in homocysteine level among all cases Moreover, homocysteine serum level in patient's group who received high dose isotretinoin (1 mg/kg/d) showed highly significant results (p = 0.001) in contrast to patient's group who received low dose isotretinoin (0.5 mg/kg/d) = 0.003). A significant increase in lipid profile and liver function test was seen in all cases. Conclusion low dose isotretinoin seems to have less side effects on basic laboratory data such as CBC, liver function tests, lipid profile and homocysteine serum levels than high dose.

Sclerosing cholangitis in a patient treated with nivolumab

2021 ◽  
Vol 14 (5) ◽  
pp. e241700
Author(s):  
Sam Talbot ◽  
Vivienne MacLaren ◽  
Heather Lafferty
Keyword(s):  
Liver Function ◽  
Sclerosing Cholangitis ◽  
Biliary Tree ◽  
Liver Function Tests ◽  
High Dose ◽  
Mr Cholangiopancreatography ◽  
Small Cell Lung ◽  
Function Tests ◽  
Stage 4 ◽  
History Of

A 69-year-old retired miner with stage 4 non-small-cell lung cancer presented with a 2-month history of obstructive liver function tests following nivolumab immunotherapy. His case had not responded to high dose prednisolone or mycophenolate and he was admitted for investigation. MR cholangiopancreatography demonstrated areas of intrahepatic biliary tree beading and stricturing, in keeping with sclerosing cholangitis. Prednisolone and mycophenolate were stopped and ursodeoxycholic acid commenced with subsequent partial improvement of the patient’s liver function tests.

scholarly journals How well do psychiatric trainees interpret electrocardiographs

1996 ◽  
Vol 20 (11) ◽  
pp. 651-652 ◽  
Author(s):  
James P. Warner ◽  
Julia A. Gledhill ◽  
Frankie Connell ◽  
John G. Coghlan
Keyword(s):  
Antipsychotic Medication ◽  
Royal College ◽  
Qt Interval ◽  
Consensus Statement ◽  
High Dose ◽  
Do So

The consensus statement by the Royal College of Psychiatrists recommended that patients on high dose antipsychotic medication receive regular electro-cardiographic monitoring to identify prolongation of the QT interval. A survey of trainee psychiatrists in three hospitals investigated the accuracy with which trainees could identify this abnormality and found only 20% could do so.

scholarly journals Neuroleptic prescribing in an adolescent psychiatric in-patient unit

1996 ◽  
Vol 20 (9) ◽  
pp. 538-540 ◽  
Author(s):  
K. Lowe ◽  
H. Smith ◽  
A. Clark
Keyword(s):  
Clinical Practice ◽  
Children And Adolescents ◽  
Antipsychotic Medication ◽  
Royal College ◽  
Psychotic Disorders ◽  
Consensus Statement ◽  
Comprehensive Evaluation ◽  
High Dose ◽  
Age Group ◽  
Antipsychotic Prescribing

The Royal College of Psychiatrists' consensus statement suggests that prescribing high dose antipsychotic medication in children and adolescents should rarely be necessary. Our objective was to study the prescribing of antipsychotic medication in a regional adolescent unit during a three-year period. We found that antipsychotic prescribing on this unit is common in psychotic disorders and often high closes are required. This is not in keeping with the recommendations of the consensus statement. Review of clinical practice on other adolescent units is needed, together with a more comprehensive evaluation of the outcome of psychotic disorders in this age group.

Routine monitoring of liver function tests in lung cancer resections – a necessary burden?

2019 ◽  
Vol 64 (3) ◽  
pp. 86-90
Author(s):  
NA Bradley ◽  
ED Kennedy ◽  
M Asif
Keyword(s):  
Decision Making ◽  
Liver Function ◽  
Clinical Decision Making ◽  
Cost Effective ◽  
Clinical Decision ◽  
Liver Function Tests ◽  
Function Tests ◽  
Routine Monitoring ◽  
Effective Manner ◽  
Collect Patient Data

Background Increased availability of routine investigations results in significant over-investigation, burdening patients with unnecessary tests as well as increasing cost. We aimed to identify the extent of monitoring of liver function tests in lung resections, and to ascertain whether any impact on clinical decision-making occurred. Methods Cases were identified using theatre records coded as “lobectomy/bilobectomy” in the three-month period 20 June 2017 to 20 September 2017. Electronic records were used to collect patient data. Results A total of 91 cases were included; 77 (85%) patients had 1 set of pre-operative LFTs, 12 (13%) patients had 2 sets, and 2 (2%) patients had 0 sets; 69 (76%) had normal LFTs pre-operatively; 298 sets of LFTs were measured post-operatively, with a median of 3 sets per patient; 61 (67%) patients had either normal or static LFTs post-operatively, 13 (14%) had isolated rise in GGT, 16 (17%) had derangement of ALT and AST, and 1 patient (1%) had deranged ALP. Altered clinical decision-making due to LFTs derangement was recorded in two cases (2%). Conclusion Clinicians have an obligation to justify expense, and practise in a cost-effective manner. Our data suggest that the routine perioperative monitoring of LFTs in thoracic surgery does not give any clear benefit to patient care.

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