Studies on Carbohydrate Metabolism in Nervous and Mental Disorders. III. The Disturbance of the Glucose-tolerance Test Caused by Hypnotics in Clinical Doses. (Edinburgh Med. Journ., vol. xliv, pp. 416–20, 1937.) Tod, H.

1937 ◽  
Vol 83 (346) ◽  
pp. 597-597
Author(s):  
Rachel Brown
Keyword(s):  
Mental Disorders ◽  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Tolerance Test

KOHLENHYDRATSTOFFWECHSEL BEI HYPERTHYREOSE: EINFLUSS EINER THYREOSTATISCHEN THERAPIE AUF ORALE UND INTRAVENÖSE GLUCOSETOLERANZ UND INSULINAKTIVITÄT

1971 ◽  
Vol 67 (2) ◽  
pp. 277-287 ◽  
Author(s):  
E. Nieschlag ◽  
B. Wördehoff ◽  
H. J. Gilfrich ◽  
J. Michaelis ◽  
C. Overzier
Keyword(s):  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Intravenous Glucose Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Initiation Of Therapy

ABSTRACT The influence of antithyroid therapy on the abnormalities of carbohydrate metabolism observed in hyperthyroidism was investigated in 10 patients. No history of diabetes mellitus was known in the patients or their families. 9 normal persons were taken as a control group. An oral and an intravenous glucose tolerance test were administered prior to and at intervals of 2 and 4 weeks after initiation of therapy. Prior to treatment an inpairment of oral glucose tolerance was observed, whereas the glucose assimilation coefficient in the intravenous glucose tolerance test was normal. Both tests however, revealed a significant rise in insulin values above normal. 2 weeks after initiation of therapy insulin values returned to normal during the intravenous glucose tolerance test. During the oral glucose tolerance test glucose and insulin concentration achieved normal levels only after 4 weeks of treatment. In all patients the abnormalities of carbohydrate metabolism observed were reversible.

scholarly journals Some cardohydrate metabolism parameters in the patients prior to and after removal of insulinoma

1993 ◽  
Vol 39 (1) ◽  
pp. 30-33 ◽  
Author(s):  
V. M. Trofimov ◽  
V. I. Mazurov ◽  
V. F. Arkhipov ◽  
N. N. Klimko
Keyword(s):  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Blood Sugar ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Blood Levels ◽  
C Peptide ◽  
Fasting Test ◽  
Organic Hyperinsulinism ◽  
Sugar Levels

Measurements of the daily fluctuations in the sugar blood levels, fasting test, the double glucose tolerance test, and measurements of the blood insulin and C peptide levels were carried out in 13 patients with organic hyperinsulinism prior to insulinoma removal and in the immediate and late periods after it. The double glucose tolerance test was for the first time used to study carbohydrate metabolism in patients with organic hyperinsulinism. The curve of this test in insulinoma patients was found to resemble that in health, though with lower levels and a more abrupt lowering of its end section. This feature may be used to define the origin of hyper insulinism. No correlation between the blood glucose, insulin, and C peptide levels was detectable before surgery in this patient population. After surgery the imbalance in these three parameters relationships is eliminated. Carbohydrate metabolism parameters normalized after the operation; the lowest blood sugar level was increased twofold in the fasting test. Transitory hyperglycemia persisted for two weeks after elimination of hyperinsulinism. Daily fluctuations in the blood sugar levels normalize during the third week after surgery.

To explain the variation of OGTT dynamics by biological mechanisms: a novel approach based on principal components analysis in women with history of GDM

2015 ◽  
Vol 309 (1) ◽  
pp. R13-R21 ◽  
Author(s):  
Christian S. Göbl ◽  
Latife Bozkurt ◽  
Martina Mittlböck ◽  
Michael Leutner ◽  
Rajashri Yarragudi ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Principal Components Analysis ◽  
Principal Components ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Hepatic Insulin Resistance ◽  
Intravenous Glucose ◽  
Components Analysis

Early reexamination of carbohydrate metabolism via an oral glucose tolerance test (OGTT) is recommended after pregnancy with gestational diabetes (GDM). In this report, we aimed to assess the dominant patterns of dynamic OGTT measurements and subsequently explain them by meanings of the underlying pathophysiological processes. Principal components analysis (PCA), a statistical procedure that aims to reduce the dimensionality of multiple interrelated measures to a set of linearly uncorrelated variables (the principal components) was performed on OGTT data of glucose, insulin and C-peptide in addition to age and body mass index (BMI) of 151 women ( n = 110 females after GDM and n = 41 controls) at 3–6 mo after delivery. These components were explained by frequently sampled intravenous glucose tolerance test (FSIGT) parameters. Moreover, their relation with the later development of overt diabetes was studied. Three principal components (PC) were identified, which explained 71.5% of the variation of the original 17 variables. PC1 (explained 47.1%) was closely related to postprandial OGTT levels and FSIGT-derived insulin sensitivity ( r = 0.68), indicating that it mirrors insulin sensitivity in the skeletal muscle. PC2 (explained 17.3%) and PC3 (explained 7.1%) were shown to be associated with β-cell failure and fasting (i.e., hepatic) insulin resistance, respectively. All three components were related with diabetes progression (occurred in n = 25 females after GDM) and showed significant changes in long-term trajectories. A high amount of the postpartum OGTT data is explained by principal components, representing pathophysiological mechanisms on the pathway of impaired carbohydrate metabolism. Our results improve our understanding of the underlying biological processes to provide an accurate postgestational risk stratification.

scholarly journals Clinical effect of thiazolidinediones in subjects with disorders of carbohydrate metabolism in case of polymorphism rs1801282

2020 ◽  
Vol 17 (2) ◽  
pp. 193-199
Author(s):  
Tatyana V. Eremenko ◽  
Nikolay A. Matsievskiy ◽  
Natalya V. Vorokhobina ◽  
Irina Y. Matesius ◽  
Irina N. Abramashvili
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Fasting Glycemia ◽  
Fasting Plasma

BACKGROUND: The polymorphism rs1801282 (Pro12Ala) may be one of the reasons for the heterogeneous response of patients with carbohydrate metabolism disorders to thiazolidinedione therapy. Studies of this polymorphism in patients with metabolic syndrome (MS) will help identify a group of patients in whom the use of thiazolidinedione is advisable. AIMS: To assess the clinical effect of thiazolidinediones in patients with metabolic syndrome, depending on the presence of polymorphism rs1801282. MATERIALS AND METHODS: All patients with newly diagnosed MS with impaired carbohydrate metabolism were included in the open cohort study. All patients were recommended a diet, expansion of physical activity and pioglitazone at a dose of 30 mg per day. After the appointment of the therapy, the patients come to the center back at 12 weeks. The main outcome in the study assessed in patients with impaired glucose tolerance (IGT) was fasting glycemia and 2 hours after glucose tolerance test, in patients with type 2 diabetes HbA1c. RESULTS: 109 patients were included in the study. Of these, 14 were carriers of rs1801282, the other 95 had a typical PPAR genotype. After the appointment of therapy in the groups of IGT and type 2 diabetes, improvement of glycemic control was observed. The degree of decrease in fasting plasma glucose and after glucose tolerance test was more pronounced with IGT in patients with polymorphism rs1801282 compared with the rest (plasma fasting plasma glucose level was -0.7 [-0.9, -0.7] vs. -0, 4 [-0.5, -0.3] mmol/L, p=0.001; plasma glucose level 2 hours after glucose tolerance test was -1.1 [-1.8, -0.3] vs. -0.5 [-0.7, -0.1] mmol/L, p=0.031). In patients with type 2 diabetes, no data were obtained for the statistically significant effect of rs1801282 polymorphism on the results of pioglitazone, but there was a tendency for a greater decrease in fasting plasma glucose in the case of carrying the polymorphic gene (-1.9 [-2.2, -1.8] against -1,5 [-1,7, -1,2] mmol/l, p=0,073). CONCLUSIONS: The study shows the effect of polymorphism rs1801282 on the results of pioglitazone in patients with MS, both in IGT and in type 2 diabetes. Carrying polymorphism leads to a significant decrease in fasting glycemia and after glucose tolerance test in patients with IGT. The tendency to improve the parameters of carbohydrate metabolism (fasting glycemia, HbA1c) was noted in a subgroup of patients with type 2 diabetes.

Characteristics of the glucose tolerance test in cerebral autonomic disorders during puberty

1986 ◽  
Vol 67 (2) ◽  
pp. 106-108
Author(s):  
M. F. Ismagilov ◽  
R. I. Alyavedinov ◽  
L. M. Sultanova ◽  
G. R. Yarullina
Keyword(s):  
Glucose Tolerance ◽  
Children And Adolescents ◽  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Autonomic Disorders

The purpose of this work was to study carbohydrate metabolism in children and adolescents of pubertal age suffering from autonomic disorders.

A double-blind cross-over study on the effects of ORG OD14 compared to oestradiol valerate and placebo on lipid and carbohydrate metabolism in oophorectomized women

1983 ◽  
Vol 102 (3) ◽  
pp. 451-455 ◽  
Author(s):  
N. Crona ◽  
G Silfverstolpe ◽  
G. Samsioe
Keyword(s):  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Marked Decrease ◽  
Clinical Stage ◽  
Density Lipoprotein ◽  
Tolerance Test ◽  
Continuous Treatment ◽  
Oral Glucose ◽  
Double Blind

Abstract. ORG OD14 is a synthetic steroid which in traditional bioassays has been shown to have oestrogenic and progestogenic as well as very weak androgenic-anabolic properties. As judged from earlier studies, this steroid seems suitable for continuous treatment of climacteric deficiency symptoms. The aim of this study was to evaluate the effects induced by OD14 on lipid, lipoprotein and carbohydrate metabolism, as compared to E2V and placebo. Twenty-two women, oophorectomized as part of the treatment of cervical carcinoma in clinical stage IB or IIA, were given ORG OD14 2.5 mg/day, oestradiol valerate (E2V) 2 mg/day and a placebo for 6 weeks each, in a double-blind cross-over study. There was a marked decrease in all lipid components of HDL (high density lipoprotein), i.e. total and free cholesterol, triglycerides and phospholipids (P < 0.001), after OD14. The oral glucose tolerance test showed higher values after OD14 compared to both E2V and placebo (P < 0.05), indicating a slightly impaired glucose tolerance. The lipid metabolic changes induced by OD14 indicate a rather strong androgenic influence in this respect.

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