KOHLENHYDRATSTOFFWECHSEL BEI HYPERTHYREOSE: EINFLUSS EINER THYREOSTATISCHEN THERAPIE AUF ORALE UND INTRAVENÖSE GLUCOSETOLERANZ UND INSULINAKTIVITÄT

1971 ◽  
Vol 67 (2) ◽  
pp. 277-287 ◽  
Author(s):  
E. Nieschlag ◽  
B. Wördehoff ◽  
H. J. Gilfrich ◽  
J. Michaelis ◽  
C. Overzier
Keyword(s):  
Glucose Tolerance ◽  
Carbohydrate Metabolism ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Intravenous Glucose Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Initiation Of Therapy

ABSTRACT The influence of antithyroid therapy on the abnormalities of carbohydrate metabolism observed in hyperthyroidism was investigated in 10 patients. No history of diabetes mellitus was known in the patients or their families. 9 normal persons were taken as a control group. An oral and an intravenous glucose tolerance test were administered prior to and at intervals of 2 and 4 weeks after initiation of therapy. Prior to treatment an inpairment of oral glucose tolerance was observed, whereas the glucose assimilation coefficient in the intravenous glucose tolerance test was normal. Both tests however, revealed a significant rise in insulin values above normal. 2 weeks after initiation of therapy insulin values returned to normal during the intravenous glucose tolerance test. During the oral glucose tolerance test glucose and insulin concentration achieved normal levels only after 4 weeks of treatment. In all patients the abnormalities of carbohydrate metabolism observed were reversible.

Insulin sensitivity in women: a comparison among values derived from intravenous glucose tolerance tests with different sampling frequency, oral glucose tolerance test or fasting

2001 ◽  
pp. 281-287 ◽  
Author(s):  
A Cagnacci ◽  
S Arangino ◽  
A Renzi ◽  
P Cagnacci ◽  
A Volpe
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Oral Glucose Tolerance Test ◽  
Glucose Tolerance Test ◽  
Polycystic Ovary ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance

OBJECTIVE: To determine the correlation between insulin sensitivity (S(I)) obtained by the minimal model method applied to a frequently sampled (n=33) intravenous glucose tolerance test (FSIGT(33)), and values obtained by reduced FSIGTs, oral glucose tolerance test (OGTT), or fasting. DESIGN: Retrospective analysis on tests performed in prospective studies. METHODS: A total of 78 FSIGT(33), and 59 OGTT were performed in non-diabetic women of which 10 were young cyclic females in the early follicular menstrual phase, 10 were young non-obese subjects with polycystic ovary syndrome (PCOS) and 30 were in post-menopause. Some of these individuals were investigated both prior to and during specified treatments. FSIGT(33) was transformed into FSIGT(22) and FSIGT(12) by removing samples from the analysis. Values of SI derived from reduced FSIGTs or calculations performed on glucose and insulin values observed in fasting conditions and/or during OGTT were related to those of FSIGT(33). RESULTS: S(I) values derived from FSIGT(33) were highly correlated with those derived from FSIGT(22) (r=0.965) or FSIGT(12) (r=0.955), but were only weakly correlated with those derived from fasting or OGTT calculations (r below 0.5). Between-group (PCOS vs normal) or within-group (prior to and during treatment) comparisons showed that reduced FSIGTs were only slightly less powerful than FSIGT(33) in detecting differences in S(I). CONCLUSIONS: In non-diabetic women, reduced FSIGTs but not calculations based on fasting or OGTT values may be used in place of FSIGT(33) to document S(I) and its variation.

APPLICATION DE LA DOUBLE ÉPREUVE D'HYPERGLYCÉMIE INTRAVEINEUSE À L'ÉTUDE DU DIABÈTE

1960 ◽  
Vol XXXIII (II) ◽  
pp. 157-167
Author(s):  
T. Rodari ◽  
G. Specchia
Keyword(s):  
Glucose Tolerance ◽  
Pancreatic Islet ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Intravenous Glucose Tolerance Test ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Glucose Assimilation

ABSTRACT The double intravenous glucose tolerance test does not modify the assimilation coefficient in normal and thin diabetic subjects. On the contrary, in fat diabetic subjects the second coefficient of assimilation increases significantly, but not the first one. From these researches it is evident that the valuation of glucose assimilation by double venous hyperglycaemic test indicates the functional behaviour of the pancreas in different diabetic states. The interpretation of this behaviour of pancreatic islet response to the double venous hyperglycaemic test is discussed.

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