scholarly journals Affective problems in adults with mild learning disability: the roles of social disadvantage and ill health

2004 ◽  
Vol 185 (4) ◽  
pp. 350-351 ◽  
Author(s):  
Stephan Collishaw ◽  
Barbara Maughan ◽  
Andrew Pickles
Keyword(s):  
Depressive Symptoms ◽  
Child Development ◽  
Learning Disability ◽  
Affective Disorder ◽  
Depressed Mood ◽  
Comparison Group ◽  
Adult Life ◽  
Economic Disadvantage ◽  
National Child Development Study ◽  
Increased Risk

SummaryMild learning disability is associated with an increased risk of affective disorder. This study examines the extent to which adult socio-economic disadvantage and ill health contribute to this risk. Samples were drawn from the 1958 National Child Development Study. Relative to a comparison group, mild learning disability at age 11 was associated with elevated rates of depressive symptoms throughout adult life, and carried a six-fold risk of chronic depressed mood. The group difference in depressed mood at age 43 years was in large part mediated by variations in adult socio-economic disadvantage and ill health.

scholarly journals Long-term affective disorder in people with mild learning disability

2001 ◽  
Vol 179 (6) ◽  
pp. 523-527 ◽  
Author(s):  
Marcus Richards ◽  
Barbara Maughan ◽  
Rebecca Hardy ◽  
Ian Hall ◽  
Andre Strydom ◽  
...  
Keyword(s):  
Learning Disability ◽  
Affective Disorder ◽  
Fourfold Increase ◽  
Frequency Scale ◽  
Medical Disorder ◽  
Increased Risk ◽  
Symptom Frequency ◽  
State Examination ◽  
Psychiatric Outcome

BackgroundIncreased risk of affective disorder in learning disability has been reported, although the extent to which this is due to adverse social and material circumstances is uncertain and there have been potential limitations in the measurement of affective disorder.AimsTo determine risk of affective disorder in those classified with mild learning disability in the British 1946 birth cohort and to investigate whether this risk was accounted for by disadvantage in childhood and adulthood.MethodLearning disability was defined as the equivalent of an IQ ≤ 69 at age 15 years. The Present State Examination at age 36 years and the Psychiatric Symptom Frequency Scale at age 43 years provided psychiatric outcome measures.ResultsLearning disability was associated with a fourfold increase in risk of affective disorder, not accounted for by social and material disadvantage or by medical disorder.ConclusionsLearning disability is strongly associated with risk of affective disorder, persisting well into midlife.

scholarly journals The Contribution of Neighborhood Socioeconomic Disadvantage to Depressive Symptoms Over the Course of Adult Life: A 32-Year Prospective Cohort Study

2020 ◽  
Vol 189 (7) ◽  
pp. 679-689 ◽  
Author(s):  
Marko Elovainio ◽  
Jussi Vahtera ◽  
Jaana Pentti ◽  
Christian Hakulinen ◽  
Laura Pulkki-Råback ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Adult Life ◽  
Repeated Measurements ◽  
Socioeconomic Disadvantage ◽  
Childhood And Adolescence ◽  
Early Exposure ◽  
Grid Data ◽  
Disadvantaged Area ◽  
Increased Risk

Abstract The association between socioeconomic disadvantage and increased risk of depressive symptoms in adulthood is well established. We tested 1) the contribution of early exposure to neighborhood socioeconomic disadvantage to later depressive symptoms throughout life, 2) the persistence of the potential association between early exposure and depressive symptoms, and 3) the contributions of other known risk factors to the association. Data were collected from the Young Finns Study, a prospective, population-based 32-year follow-up study that included participants aged 3–18 years at baseline in 1980. Participants were followed up with repeated measurements of depressive symptoms between 1992 and 2012 (n = 2,788) and linked to national grid data on neighborhood disadvantage via residential addresses. We examined the associations in mixed models separately for the 5-, 10-, 15-, and 20-year follow-ups. Living in a disadvantaged neighborhood during childhood and adolescence was associated with a higher level of depressive symptoms in adulthood during all follow-up periods (β = 0.07, P = 0.001) than living in a nondisadvantaged area. Individual adulthood socioeconomic status mediated the associations. These findings suggest that living in a socioeconomically disadvantaged area during childhood and adolescence has a long-lasting negative association with mental health irrespective of family-related risks, partially due to socioeconomic adversity later in life.

Psychosocial predictors of asthma onset during mid-adulthood: evidence from the National Child Development Study

2020 ◽  
Vol 11 (4) ◽  
pp. 459-493
Author(s):  
Cathie Hammond
Keyword(s):  
Depressive Symptoms ◽  
Child Development ◽  
Life Course ◽  
Missing Values ◽  
Childhood Adversity ◽  
Development Study ◽  
National Child Development Study ◽  
Nested Models ◽  
Wide Range ◽  
Multiple Data Sets

This paper provides evidence about how psychosocial factors predict asthma onset during mid-adulthood. Questions addressed are:1. Do life course adversities predict asthma onset? What types of adversity are important?2. What factors confound and mediate associations between childhood adversity and asthma onset?3. In the context of life course adversity, do psychological factors predict asthma onset?Data from the National Child Development Study from birth to age 42 were used. Asthma onset was measured between 33 and 42.To reduce bias and maintain numbers, missing values were imputed in multiple data sets. Logistic regression analyses were conducted of asthma onset on life course adversities, classified as material (including occupation-related) and social (family-/relationship-related, child loss, traumatic). Nested models were used to address questions 2 and 3, and a wide range of factors tested.After adjustment for gender, asthma onset during mid-adulthood was more common among cohort members who reported life course adversities (odds ratio per category = 1.232 (1.140–1.332)) in eight categories. Social adversities predicted asthma onset after adjustment for material adversities. The association between childhood adversity and asthma onset was mediated by subsequent adversity and depressive symptoms at 33. Asthma onset was predicted by female gender, atopic history, life course adversity, internalising childhood temperament and depressive symptoms at 33.This study contributes to a small evidence base that life course adversities substantially increase the risk of adult-onset asthma, and highlights the importance of psychosocial pathways. The salience of depressive symptoms shortly before diagnosed onset is a new finding.

scholarly journals Early Childhood Education and Adult Depression: An Attrition Reanalysis With Inverse Propensity Score Weighting

2020 ◽  
pp. 0193841X2097652
Author(s):  
Christina F. Mondi ◽  
Arthur J. Reynolds ◽  
Brandt A. Richardson
Keyword(s):  
Early Childhood ◽  
Depressive Symptoms ◽  
Comparison Group ◽  
Practical Significance ◽  
Point Estimate ◽  
Marginal Effect ◽  
Alternative Analysis ◽  
Point Reduction ◽  
Program Selection ◽  
Matched Comparison

In a previous study of the Child-Parent Centers (CPC) education program, preschool participation was linked to a 4.6 percentage point reduction (26%) in depressive symptoms at ages 22–24 over the matched comparison group enrolling the usual programs. The present study reanalyzed these data in the Chicago Longitudinal Study to address potential attrition bias since more than a quarter of the sample was missing on the outcome. Using inverse probability weighting (IPW) involving 32 predictors of sample retention, findings for the 1,142 participants growing up in high-poverty neighborhoods indicated that CPC participation was associated with a 7.1 percentage point reduction (95% CI = [−9.7, −5.4]) in one or more depressive symptoms (39% reduction over the comparison group). Although this marginal effect was within the confidence interval of the original study (95% CI = [−9.5, 0.3]), the 54% increase in the point estimate is substantial and of practical significance, suggesting underestimation in the prior study. Alternative analysis of different predictors and IPW models, including adjustments for program selection and attrition together, yielded similar results. Findings indicate that high-quality early childhood programs continue to be an important strategy for the prevention of depression and its debilitating effects on individuals and families.

scholarly journals Foster Parents’ Parenting and the Social-Emotional Development and Adaptive Functioning of Children in Foster Care: A PRISMA-Guided Literature Review and Meta-Analysis

2021 ◽  
Author(s):  
Sabrina Chodura ◽  
Arnold Lohaus ◽  
Tabea Symanzik ◽  
Nina Heinrichs ◽  
Kerstin Konrad
Keyword(s):  
Foster Care ◽  
Child Development ◽  
Literature Review ◽  
Foster Parents ◽  
Meta Analysis ◽  
Developmental Outcomes ◽  
Parenting Behavior ◽  
Foster Families ◽  
Children In Foster Care ◽  
Increased Risk

AbstractChildren in foster care (CFC) are at increased risk for negative developmental outcomes. Given the potential influence of foster parents’ parenting on the development of CFC, this literature review and meta-analysis provide an initial overview of how parenting factors in foster families relate to CFC’s developmental outcomes. We aimed to explore (1) whether foster parents’ parenting conceptualizations are related differently to various CFC developmental outcome variables and (2) how characteristics of foster parents and CFC moderate these associations. Following the recommendations of the PRISMA statement, we searched four databases in 2017 (with an update in May 2020). Forty-three primary studies were coded manually. The interrater agreement was 92.1%. Parenting variables were specified as parenting behavior, style, and goals and were distinguished further into functional and dysfunctional parenting. CFC development was divided into adaptive (including cognitive) development and maladaptive development. Meta-analyses could be performed for foster parenting behavior and developmental outcomes, as well as for functional parenting goals and maladaptive socioemotional outcomes in CFC. Associations between functional parenting behavior and adaptive child development were positive and negative for maladaptive child development, respectively. For dysfunctional, parenting effects were in the opposite direction. All effects were small to moderate. Similar results were found descriptively in the associations of parenting style and child developmental outcomes. We found similar effect sizes and directions of the associations between parenting behavior in foster families and the child’s developmental outcomes as those previously reported for biological families. These findings provide strong support for the significant role of parenting in foster families regarding children’s development in foster care.

756 The Moderating Influence of Depression on Insomnia and Suicidal Ideation in a Military Sample

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A294-A295
Author(s):  
Emma Palermo ◽  
Jennifer Goldschmied ◽  
Elaine Boland ◽  
Elizabeth A Klingaman ◽  
Philip Gehrman ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Research University ◽  
Negative Binomial ◽  
Suicide Attempts ◽  
Risk And Resilience ◽  
Depression Severity ◽  
Significant Interaction Effect ◽  
Increased Risk ◽  
The Impact

Abstract Introduction Military personnel are at an increased risk for suicide compared to the general population, making it important to develop a deeper understanding of which factors contribute to this elevated risk. Given that suicidal ideation (SI) is one of the strongest predictors of suicide attempts, understanding factors that underlie SI may improve prevention efforts. Insomnia and depression both serve as independent risk factors for SI, and therefore the aim of this study was to examine the extent to which depressive symptoms moderate the association between insomnia and SI. Methods Data were obtained from the All Army Study of the Army Study to Assess Risk and Resilience in Servicemembers (STARRS). Soldiers (n=21,450) completed questions related to suicidal ideation (5 items), depressive symptoms (9 items), and insomnia (5 items) based on symptom presence in the past 30 days. Items in each domain were summed to create a total severity score. GEE models using a negative binomial linking function were conducted to examine the impact of depression, insomnia, and their interaction on SI. Results Both depression (χ2 =117.56, p<0.001) and insomnia (χ2=11.79, p=0.0006) were found to have significant main effects on SI, and there was a significant interaction effect (χ2=4.52, p=0.0335). Follow up simple effects revealed that insomnia was no longer significantly associated with SI when depression severity was low, but was associated with SI in the presence of greater depression severity (χ2=2.91, p=0.0882). Conclusion In a large sample of Army soldiers, depression significantly moderated the association between SI and insomnia, such that insomnia seems to amplify the effects of depression on SI. These findings highlight the importance of addressing insomnia severity as a mean of reducing SI in those with depression, potentially allowing for intervention prior to a suicide attempt. Support (if any) Perlis: K24AG055602 & R01AG041783. This publication is based on public use data from Army STARRS (Inter-university Consortium for Political and Social Research, University of Michigan- http://doi.org/10.3886/ICPSR35197-v1), funded by U.S. NIMH-U01MH087981.

scholarly journals The politics of the excluded: abjection and reconciliation amongst the British precariat

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Mike Savage ◽  
Cynthia Meersohn Schmidt
Keyword(s):  
Child Development ◽  
Cultural Capital ◽  
Representative Sample ◽  
Qualitative Data ◽  
Social Identities ◽  
Popular Politics ◽  
Development Study ◽  
National Child Development Study ◽  
Nationally Representative ◽  
Contemporary Britain

AbstractIn this paper, we use a powerful empirical resource to address what the popular politics of disadvantage might entail in contemporary Britain. We take advantage of the unusually rich qualitative data from the British National Child Development Study, a cohort of Britons born in 1 week in 1958, to focus specifically on the accounts of those who are particularly disadvantaged. By concentrating on these a small number of qualitative accounts, which have been rigorously selected from the wider nationally representative sample on the basis of their relatively small amounts of economic and cultural capital, we will explore in detail the accounts and identities of these disadvantaged Britons with a view to explicating their political frameworks, their social identities and more broadly their orientations towards mobilisation.

scholarly journals Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality: an application of multistate models in a prospective cohort study

2021 ◽  
pp. svn-2020-000693
Author(s):  
Yanan Qiao ◽  
Siyuan Liu ◽  
Guochen Li ◽  
Yanqiang Lu ◽  
Ying Wu ◽  
...  
Keyword(s):  
Heart Disease ◽  
Depressive Symptoms ◽  
Depression Scale ◽  
European Population ◽  
Multistate Models ◽  
Cardiometabolic Diseases ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Patients With Diabetes

Background and purposeThe role of depression in the development and outcome of cardiometabolic diseases remains to be clarified. We aimed to examine the extent to which depressive symptoms affect the transitions from healthy to diabetes, stroke, heart disease and subsequent all-cause mortality in a middle-aged and elderly European population.MethodsA total of 78 212 individuals aged ≥50 years from the Survey of Health Ageing and Retirement in Europe were included. Participants with any baseline cardiometabolic diseases including diabetes, stroke and heart disease were excluded. Depressive symptoms were measured by the Euro-Depression scale at baseline. Participants were followed up to determine the occurrence of cardiometabolic diseases and all-cause mortality. We used multistate models to estimate the transition-specific HRs and 95% CIs after adjustment of confounders.ResultsDuring 500 711 person-years of follow-up, 4742 participants developed diabetes, 2173 had stroke, 5487 developed heart disease and 7182 died. Depressive symptoms were significantly associated with transitions from healthy to diabetes (HR: 1.12, 95% CI: 1.05 to 1.20), stroke (HR: 1.31, 95% CI: 1.18 to 1.44), heart disease (HR: 1.26, 95% CI: 1.18 to 1.34) and all-cause mortality (HR: 1.41, 95% CI: 1.34 to 1.49). After cardiometabolic diseases, depressive symptoms were associated with the increased risk of all-cause mortality in patients with diabetes (HR: 1.54, 95% CI: 1.25 to 1.89), patients who had stroke (HR: 1.29, 95% CI: 1.03 to 1.61) and patients with heart disease (HR: 1.21, 95% CI: 1.02 to 1.44).ConclusionsDepressive symptoms increase the risk of diabetes, stroke and heart disease, and affect the risk of mortality after the onset of these cardiometabolic conditions. Screening and treatment of depressive symptoms may have profound implications for the prevention and prognosis of cardiometabolic diseases.

The non-specific nature of mental health and structural brain outcomes following childhood trauma

2021 ◽  
pp. 1-10
Author(s):  
Theresa K. Haidl ◽  
Dennis M. Hedderich ◽  
Marlene Rosen ◽  
Nathalie Kaiser ◽  
Mauro Seves ◽  
...  
Keyword(s):  
Mental Health ◽  
Risk Factor ◽  
Depressive Symptoms ◽  
Childhood Trauma ◽  
Brain Structure ◽  
Mental Health Disorders ◽  
Recent Onset ◽  
Increased Risk ◽  
Health Disorders ◽  
Structural Brain

Abstract Background Childhood trauma (CT) is associated with an increased risk of mental health disorders; however, it is unknown whether this represents a diagnosis-specific risk factor for specific psychopathology mediated by structural brain changes. Our aim was to explore whether (i) a predictive CT pattern for transdiagnostic psychopathology exists, and whether (ii) CT can differentiate between distinct diagnosis-dependent psychopathology. Furthermore, we aimed to identify the association between CT, psychopathology and brain structure. Methods We used multivariate pattern analysis in data from 643 participants of the Personalised Prognostic Tools for Early Psychosis Management study (PRONIA), including healthy controls (HC), recent onset psychosis (ROP), recent onset depression (ROD), and patients clinically at high-risk for psychosis (CHR). Participants completed structured interviews and self-report measures including the Childhood Trauma Questionnaire, SCID diagnostic interview, BDI-II, PANSS, Schizophrenia Proneness Instrument, Structured Interview for Prodromal Symptoms and structural MRI, analyzed by voxel-based morphometry. Results (i) Patients and HC could be distinguished by their CT pattern with a reasonable precision [balanced accuracy of 71.2% (sensitivity = 72.1%, specificity = 70.4%, p ≤ 0.001]. (ii) Subdomains ‘emotional neglect’ and ‘emotional abuse’ were most predictive for CHR and ROP, while in ROD ‘physical abuse’ and ‘sexual abuse’ were most important. The CT pattern was significantly associated with the severity of depressive symptoms in ROD, ROP, and CHR, as well as with the PANSS total and negative domain scores in the CHR patients. No associations between group-separating CT patterns and brain structure were found. Conclusions These results indicate that CT poses a transdiagnostic risk factor for mental health disorders, possibly related to depressive symptoms. While differences in the quality of CT exposure exist, diagnostic differentiation was not possible suggesting a multi-factorial pathogenesis.

Mechanisms involved in developmental programming of hypertension and renal diseases. Gender differences

2014 ◽  
Vol 18 (2) ◽  
Author(s):  
Analia Lorena Tomat ◽  
Francisco Javier Salazar
Keyword(s):  
Metabolic Diseases ◽  
Current Knowledge ◽  
Adult Life ◽  
Developmental Programming ◽  
Renal Diseases ◽  
Future Studies ◽  
Functional Changes ◽  
Regulatory Systems ◽  
Increased Risk ◽  
Renal Changes

AbstractA substantial body of epidemiological and experimental evidence suggests that a poor fetal and neonatal environment may “program” susceptibility in the offspring to later development of cardiovascular, renal and metabolic diseases.This review focuses on current knowledge from the available literature regarding the mechanisms linking an adverse developmental environment with an increased risk for cardiovascular, renal and metabolic diseases in adult life. Moreover, this review highlights important sex-dependent differences in the adaptation to developmental insults.Developmental programming of several diseases is secondary to changes in different mechanisms inducing important alterations in the normal development of several organs that lead to significant changes in birth weight. The different diseases occurring as a consequence of an adverse environment during development are secondary to morphological and functional cardiovascular and renal changes, to epigenetic changes and to an activation of several hormonal and regulatory systems, such as angiotensin II, sympathetic activity, nitric oxide, COX2-derived metabolites, oxidative stress and inflammation. The important sex-dependent differences in the developmental programming of diseases seem to be partly secondary to the effects of sex hormones. Recent studies have shown that the progression of these diseases is accelerated during aging in both sexes.The cardiovascular, renal and metabolic diseases during adult life that occur as a consequence of several insults during fetal and postnatal periods are secondary to multiple structural and functional changes. Future studies are needed in order to prevent the origin and reduce the incidence and consequences of developmental programmed diseases.

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