Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women

1999 ◽  
Vol 175 (4) ◽  
pp. 351-356 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Laura M. Karkowski ◽  
Linda A. Corey ◽  
Carol A. Prescott ◽  
Michael C. Neale
Keyword(s):  
Risk Factors ◽  
Substance Use ◽  
Family Environment ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Initial Exposure ◽  
History Of ◽  
The Individual

BackgroundSubsequent to initial exposure to the use of a psychoactive substance, psychoactive substance use disorder (PSUD) may or may not develop.AimsTo investigate the relationship between the risk factors for initiation and the subsequent misuse of psychoactive substances.MethodThe lifetime history of illicit substance use and misuse was obtained by telephone interview with 1934 members of female–female twin pairs. We apply a novel model, which estimates the role of genetic and environmental risk factors that influence initiation and those specific to misuse, to three classes of illicit psychoactive substances.ResultsThe individual-specific environment and family environment influenced the probability of initiation, but only individual-specific environment had an impact on the probability of subsequent misuse. Genetic factors which influence the risk of initiation and of misuse were identified.ConclusionsAetiological factors that influence drug initiation and subsequent misuse are correlated but not identical. Family environment is an important determinant of risk for drug experimentation. Two classes of genetic risk factors act on the liability to PSUD: those that influence the probability of initiation and those that influence the risk of misuse.

scholarly journals Risk factors of early psychoactive substances dependence among youth

2022 ◽  
pp. 174-179
Author(s):  
R. M. Sadykov ◽  
N. L. Bolshakova
Keyword(s):  
Risk Factors ◽  
Substance Use ◽  
Parental Involvement ◽  
Family Income ◽  
Peer Groups ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Number Of Factors ◽  
Psychoactive Substance Use ◽  
Informal Groups

The article considers a number of factors that influence the use of psychoactive substances by young people in Russia: psychological, social, economic, medico-biological, spiritual and moral and others. The main reasons for psychoactive substance use among this age group are: neglect by parents, psychoactive substance use by parents and other relatives, abuse by parents and guardians, low family income, conflicts and lack of understanding of the age-specific characteristics of adolescents by parents, low motivation to study, low status among peer groups, youth informal groups. In addition to risk factors, protection factors – circumstances that reduce the likelihood of a person becoming involved with psychoactive substances have also been identified: a strong family, with a healthy and supportive psychological atmosphere, success in educational activities, parental involvement in the life of their children, etc. 

Genetic and environmental risk factors in adolescent substance use

2003 ◽  
Vol 44 (5) ◽  
pp. 664-676 ◽  
Author(s):  
Judy Silberg ◽  
Michael Rutter ◽  
Brian D'Onofrio ◽  
Lindon Eaves
Keyword(s):  
Risk Factors ◽  
Substance Use ◽  
Environmental Risk ◽  
Environmental Risk Factors ◽  
Adolescent Substance Use ◽  
Adolescent Substance

scholarly journals Mapping And Analysis of Environmental Risk Factors Leptospirosis Incidence Based Geographic Information System (GIS) In Sampang Regency

2016 ◽  
Vol 8 (1) ◽  
pp. 48
Author(s):  
Annisa Rahim ◽  
Ririh Yudhastuti
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Cross Sectional Study ◽  
Environmental Risk Factors ◽  
Sectional Study ◽  
Cross Sectional ◽  
Unit Of Analysis ◽  
Incidence Risk ◽  
History Of ◽  
Observational Descriptive Study

Abstract: One  of the  zoonosis in Indonesia is leptospirosis. Leptospirosis is caused due  to infection  of bacteria Leptospira. There  were  107 cases and  9 deaths due  to leptospirosis in Sampang. The  incidence of leptospirosis in Sampang was an outbreak. The purpose of this study  was to map the distribution  of leptospirosis cases in Sampang in 2013 and to analyze environmental risk factors of leptospirosis cases (rainfall, altitude, and the presence of flood). This study  was an observational-descriptive study  and used cross-sectional study  design. The unit of analysis  of the study was administrative  regions  based on the districts.  There was patients  of leptospirosis in 4 districts in Sampang regency, there are Sampang district, Camplong district Robatal district and Omben district. The highest incidence of leptospirosis in Sampang regency was occured in Sampang district with rainfall more than 177.6 mm,  altitude less  than 47mdpl, and had experienced flooding.  Mapping  the incidence of leptospirosis showed the distribution  of leptospirosis cases tend to be  concentrated in Sampang district which  had a history of flooding  status.  The conclusion is rainfall, altitude, and presence of flood are risk factors  of leptospirosis. The advice is to improve  surveillance of patients  with leptospirosis particularly during floods,  to do outreach to the community, to perform cross-sector cooperation, to avoid or to reduce the frequency of direct contact with the flood to minimize  transmission of leptospirosis.Keywords: leptospirosis incidence, risk factors,  mapping

scholarly journals Prevalence and reasons of use of different psychoactive substances among prisoners at Malir Prison, Karachi.

2020 ◽  
Vol 27 (07) ◽  
pp. 1488-1492
Author(s):  
Muhammad Ilyas Jat ◽  
Muhammad Tarique Arain ◽  
Saima Qureshi ◽  
Kheenpal Das ◽  
Anum Haider
Keyword(s):  
Substance Use ◽  
Peer Pressure ◽  
Cross Sectional Study ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Ethical Considerations ◽  
Cross Sectional ◽  
History Of ◽  
Male Prisoners ◽  
Study Setting

The use psychoactive substances are on the rise in general population and even seen more among those who are involved in criminal activities. There are many reasons for such irrational use of psychoactive substances. Objectives: To determine the prevalence and reasons of use of different psychoactive substances among prisoners at Malir prison, Karachi. Study Design: Descriptive Cross-Sectional study. Setting: Malir prison, Karachi. Period: 22nd April 2019 to 26th May 2019. Material & Methods: This study was conducted at district Malir prison, Karachi. All the cases who were imprisoned due to any reason and had history of psychoactive substance use were enrolled. Thorough history and examination was carried out. Ethical considerations were taken as per international guidelines. Results: Among all 490 male prisoners who used to take different type of psychoactive substance, majority were of age ranges of 21 to 35 years and 55% were married while 44% were single and 1% were divorced or separated. Out of 490 cases 453 (92%) were using different substances thorough routes other than injections while 37 (8%) were injection users. Majority of prisoners 252 (52%) were using Heroin while 86 (17%) were using Crystals, 74 (15%) Cannabis, 37 (8%) Synthetic substances, 24 (5%) Ice, 6 (1%) Opioid and 11 (2%) were using some other type of substance. The most common reason of substance use was peer pressure followed by fun and frustration. Conclusion: Substance use prevalence is high in prison. Existing services for the management of drug dependence are not meeting the global standard of evidence based comprehensive drug treatment and rehabilitation.

Bulimia nervosa and major depression: a study of common genetic and environmental factors

1992 ◽  
Vol 22 (3) ◽  
pp. 617-622 ◽  
Author(s):  
Ellen E. Walters ◽  
Michael C. Neale ◽  
Lindon J. Eaves ◽  
Andrew C. Heath ◽  
Ronald C. Kessler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depression ◽  
Environmental Factors ◽  
Family Environment ◽  
Environmental Risk ◽  
Population Based ◽  
Environmental Risk Factors ◽  
Future Research ◽  
Clinical Diagnoses ◽  
Genetic And Environmental Factors

SynopsisA genetic analysis of the co-occurrence of bulimia and major depression (MD) was performed on 1033 female twin pairs obtained from a population based register. Personal interviews were conducted and clinical diagnoses made according to DSM-III-R criteria.Additive genes, but not family environment, are found to play an important aetiological role in both bulimia and MD. The genetic liabilities of the two disorders are correlated 0·456. While unique environmental factors account for around half of the variation in liability to both bulimia and MD, these risk factors appear to be unrelated, i.e., each disorder has its own set of unique environmental risk factors. Thus, the genetic liability of bulimia and MD is neither highly specific nor entirely nonspecific. There is some genetic correlation between the two disorders as well as some genetic and environmental risk factors unique to each disorder. Limitations and directions for future research are discussed.

scholarly journals Nigerian Medical Students’ Opinions about Individuals who use and Abuse Psychoactive Substances

2013 ◽  
Vol 7 ◽  
pp. SART.S12129
Author(s):  
Bawo O. James ◽  
Joyce O. Omoaregba
Keyword(s):  
Substance Use ◽  
Medical Students ◽  
Attitude Scale ◽  
Health Providers ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Positive Attitudes ◽  
History Of ◽  
Psychoactive Substance Use ◽  
Use Factors

Substance use disorders are prevalent in Nigeria. The number of available specialist health providers is inadequate to fill the treatment gap. Interventions can be provided by nonspecialist health providers and have been found to be beneficial. However, attitudes toward substance misuse and misusers can impede the provision of this service. We aimed to determine attitudes of medical trainees toward substance use by utilizing a modified form of the Substance Abuse Attitude Scale (SAAS). Medical students (n = 200) had positive attitudes toward individuals who misuse psychoactive substances. The medial students, however, preferred treatment to be offered by trained specialists and held restrictive views regarding cannabis and alcohol use. More positive attitudes were expressed by participants who were male or had a lifetime history of psychoactive substance use. The role of personal and family-related psychoactive substance use factors are probably associated with attitudinal responses and would require further exploration.

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