Neuropsychological function in euthymic patients with bipolar disorder

1999 ◽  
Vol 175 (3) ◽  
pp. 246-251 ◽  
Author(s):  
I. N. Ferrier ◽  
Biba R. Stanton ◽  
T. P. Kelly ◽  
Jan Scott
Keyword(s):  
Bipolar Disorder ◽  
Executive Function ◽  
Depressive Symptoms ◽  
Neuropsychological Tests ◽  
Good Evidence ◽  
Neuropsychological Impairment ◽  
Neuropsychological Function ◽  
Limited Evidence ◽  
Neuropsychological Dysfunction ◽  
Low Levels

BackgroundThe assumption that patients with bipolar disorder make a full inter-episode recovery has been challenged by limited evidence that suggests that neuropsychological dysfunction in bipolar disorder may persist beyond episodes of illness.AimsTo test the hypothesis that patients with euthymic bipolar disorder show neuropsychological impairment.MethodA battery of neuropsychological tests (assessed attention, working memory, learning and executive function) was administered to three matched groups of subjects: good-outcome patients with bipolar disorder (n=21); poor-outcome patients with bipolar disorder (n=20); controls (n=20). All patients were clinically euthymic, although some had low levels of depressive symptoms.ResultsPatients performed worse than controls on a number of neuropsychological tests. When age, premorbid IQ and depressive symptoms were controlled for, the results indicated impairment of executive function.ConclusionsThese findings provide good evidence for the existence of neuropsychological impairment in patients with euthymic bipolar disorder, although the possible effect of medication should not be overlooked. This may be of clinical relevance and raises questions about the course and outcome of the illness.

Neuropsychological function in bulimia with comorbid borderline personality disorder and depression

2006 ◽  
Vol 18 (3-4) ◽  
pp. 162-167 ◽  
Author(s):  
Cecilia M. Bourke ◽  
Richard J. Porter ◽  
Patrick Sullivan ◽  
Cynthia M. Bulik ◽  
Frances A. Carter ◽  
...  
Keyword(s):  
Executive Function ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Neuropsychological Tests ◽  
Neuropsychological Test ◽  
Borderline Personality ◽  
Neuropsychological Function ◽  
Test Results ◽  
Trail Making ◽  
The Impact

Background:In bulimia nervosa (BN), borderline personality disorder (BPD) and major depression (MDD) are frequently comorbid conditions. Executive function has been found to be impaired in BPD and MDD, but the impact of comorbidity on neuropsychological function has rarely been investigated.Objective:To investigate neuropsychological function in BN with a focus on comorbid BPD and MDD.Methods:One hundred forty-four medication-free female patients entering a study of psychological treatments for BN performed a brief battery of neuropsychological tests. Comorbid MDD and BPD were systematically identified using standard interviews. Neuropsychological test results were compared.Results:Forty-one subjects had comorbid BPD and 35 had comorbid MDD, while 15 had both. There was no effect of comorbid MDD, but there was a significant effect of BPD and a significant interaction between the diagnosis of MDD and BPD on executive tasks (trail making and Stroop). Thus, compared with subjects without BPD, subjects with BPD performed significantly worse on tests of executive function, while the group with both comorbidities performed even worse.Conclusions:There appears to be an additive effect of BPD and MDD resulting in impaired executive neuropsychological function. Future studies on either disorder and on BN should examine and account for the effect of comorbidity.

scholarly journals Insight and Neuropsychological Function in Patients with Schizophrenia and Bipolar Disorder with Psychotic Features

2003 ◽  
Vol 48 (5) ◽  
pp. 338-341 ◽  
Author(s):  
Luca Arduini ◽  
Artemis Kalyvoka ◽  
Paolo Stratta ◽  
Osvaldo Rinaldi ◽  
Enrico Daneluzzo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Mental Disorder ◽  
Neuropsychological Tests ◽  
Social Consequences ◽  
Wisconsin Card Sort Test ◽  
Neuropsychological Function ◽  
Card Sort ◽  
Total Group ◽  
Frontal Lobe Function ◽  
Psychotic Features

Objectives: This study investigates the pattern of association between patient unawareness of illness and neuropsychological tests of frontal lobe function in subjects with schizophrenia and bipolar disorder (BD) with psychotic features. Method: We administered the Wisconsin Card Sort Test (WCST) and a shortened version of the Scale to Assess Unawareness of Mental Disorder (SUMD) to a sample of 64 patients with psychosis (42 with schizophrenia and 22 with BD). Results: None of the correlations between WCST scores and insight scores were statistically significant, either in the total group or in each group analyzed separately. Further, no differences were seen in insight scores between sexes and between the diagnostic groups. Conclusions: The 3 insight dimensions (that is, awareness of mental disorder, awareness of social consequences of mental disorder, and awareness of the benefits of medication) do not appear to be associated with frontal impairment, as measured by the WCST.

scholarly journals Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine

2011 ◽  
Vol 2011 ◽  
pp. 1-24 ◽  
Author(s):  
Benjamin P. Chapman ◽  
Brent Roberts ◽  
Paul Duberstein
Keyword(s):  
Public Health ◽  
Personalized Medicine ◽  
Personality Traits ◽  
Perceived Control ◽  
Good Evidence ◽  
Limited Evidence ◽  
Emotional Suppression ◽  
Type D ◽  
Low Levels ◽  
And Personalized Medicine

We review evidence for links between personality traits and longevity. We provide an overview of personality for health scientists, using the primary organizing framework used in the study of personality and longevity. We then review data on various aspects of personality linked to longevity. In general, there is good evidence that higher level of conscientiousness and lower levels of hostility and Type D or “distressed” personality are associated with greater longevity. Limited evidence suggests that extraversion, openness, perceived control, and low levels of emotional suppression may be associated with longer lifespan. Findings regarding neuroticism are mixed, supporting the notion that many component(s) of neuroticism detract from life expectancy, but some components at some levels may be healthy or protective. Overall, evidence suggests various personality traits are significant predictors of longevity and points to several promising directions for further study. We conclude by discussing the implications of these links for epidemiologic research and personalized medicine and lay out a translational research agenda for integrating the psychology of individual differences into public health and medicine.

scholarly journals Neuropsychological dysfunction, soft neurological signs and social disability in euthymic patients with bipolar disorder

2006 ◽  
Vol 188 (4) ◽  
pp. 366-373 ◽  
Author(s):  
Utpal Goswami ◽  
Aditya Sharma ◽  
Udayan Khastigir ◽  
Ian Nicol Ferrier ◽  
Allan H. Young ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Executive Function ◽  
Verbal Memory ◽  
Psychosocial Functioning ◽  
Executive Dysfunction ◽  
Neurocognitive Deficits ◽  
Social Disability ◽  
Neuropsychological Dysfunction ◽  
Neurological Signs ◽  
Mood Symptoms

BackgroundNeurocognitive deficits exist in euthymic patients with bipolar disorder, but relationships between symptoms, psychosocial and neurological factors remain uncertain.AimsTo measure neurocognitive function in bipolar disorder and explore links to sub-syndromal mood symptoms, soft neurological signs and psychosocial impairment.MethodAttention, memory and executive function were tested in 37 euthymic patients with bipolar disorder and 37 controls. Psychosocial functioning, soft neurological signs and residual mood symptoms were assessed.ResultsPerformances on tests reflecting executive function and verbal memory (but not attention) were significantly poorer in the bipolar disorder group. Sub-syndromal mood symptoms produced small cognitive effects, predominantly on verbal memory. Soft neurological signs, especially frontal signs, were marked; some patients showed marked social disability which correlated strongly with soft neurological signs but weakly with executive dysfunction, which was linked to illness episodes.ConclusionsCognitive dysfunction, social dysfunction and soft signs occur in euthymic patients with bipolar disorder and may represent trait deficits.

Living in squalor: neuropsychological function, emotional processing and squalor perception in patients found living in squalor

2010 ◽  
Vol 23 (5) ◽  
pp. 724-731 ◽  
Author(s):  
Carol Gregory ◽  
Graeme Halliday ◽  
John Hodges ◽  
John Snowdon
Keyword(s):  
Executive Function ◽  
Theory Of Mind ◽  
Neuropsychological Tests ◽  
Emotional Processing ◽  
Living Conditions ◽  
Neuropsychological Function ◽  
Neural Basis ◽  
Wide Range ◽  
Old Age Psychiatry ◽  
Frontal Systems

ABSTRACTBackground: Patients living in squalor have a wide range of psychiatric diagnoses, but these may have a common neural basis involving frontal systems. This study investigated frontal executive function, theory of mind, emotional processing including disgust, and appreciation of squalor in elderly patients found living in squalor.Methods: Six patients referred to an old age psychiatry service underwent a battery of neuropsychological tests, assessment of living conditions and awareness of self and others’ squalor.Results: All six patients showed impairment in frontal executive function, typically accompanied by amnesic deficits. Theory of mind and emotional processing were surprisingly preserved. While five of the patients could recognize severely unclean or cluttered living conditions in newspaper photographs, more than half did not appreciate that their own living conditions were squalid.Conclusion: Deficits in frontal executive function appear important in the genesis of squalor although functions linked to orbito-frontal ability appear preserved.

Empathy in context: Socioeconomic status as a moderator of the link between empathic accuracy and well-being in married couples

2021 ◽  
pp. 026540752199075
Author(s):  
Emily F. Hittner ◽  
Claudia M. Haase
Keyword(s):  
Socioeconomic Status ◽  
Life Satisfaction ◽  
Depressive Symptoms ◽  
Marital Satisfaction ◽  
Negative Affect ◽  
Marital Conflict ◽  
Married Couples ◽  
Well Being ◽  
Empathic Accuracy ◽  
Low Levels

The present laboratory-based study investigated socioeconomic status (SES) as a moderator of the association between empathic accuracy and well-being among married couples from diverse socioeconomic backgrounds. Empathic accuracy was measured using a performance-based measure of empathic accuracy for one’s spouse’s negative emotions during a marital conflict conversation. Aspects of well-being included well-being (i.e., positive affect, life satisfaction), ill-being (i.e., negative affect, anxiety symptoms, depressive symptoms), and marital satisfaction. SES was measured using a composite score of income and education. Findings showed that SES moderated associations between empathic accuracy and well-being. Empathic accuracy was beneficial (for well-being and ill-being) or not harmful (for marital satisfaction) at low levels of SES. In contrast, empathic accuracy was not beneficial (for well-being and ill-being) or harmful (for marital satisfaction) at high levels of SES. Results were robust (controlled for age, gender, and race). Findings are discussed in light of interdependence vs. independence in low- vs. high-SES contexts and highlight the importance of socioeconomic context in determining whether empathic accuracy benefits well-being or not.

scholarly journals Study of the Interaction between Executive Function and Adaptive Behavior at School in Girls with Fragile X Syndrome

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1108
Author(s):  
Lorena Joga-Elvira ◽  
Jennifer Martinez-Olmo ◽  
María-Luisa Joga ◽  
Carlos Jacas ◽  
Ana Roche-Martínez ◽  
...  
Keyword(s):  
Executive Function ◽  
Executive Functions ◽  
Fragile X Syndrome ◽  
Adaptive Behavior ◽  
Neuropsychological Tests ◽  
Rating Scale ◽  
Fragile X ◽  
School Setting ◽  
Control Group ◽  
The Relationship

The aim of this research is to analyze the relationship between executive functions and adaptive behavior in girls with Fragile X syndrome (FXS) in the school setting. This study is part of a larger investigation conducted at the Hospital Parc Tauli in Sabadell. The sample consists of a total of 40 girls (26 with FXS and 14 control) aged 7–16 years, who were administered different neuropsychological tests (WISC-V, NEPSY-II, WCST, TOL) and questionnaires answered by teachers (ABAS-II, BRIEF 2, ADHD Rating Scale). The results show that there is a greater interaction between some areas of executive function (cognitive flexibility, auditory attention, and visual abstraction capacity) and certain areas of adaptive behavior (conceptual, practical, social, and total domains) in the FXS group than in the control group. These results suggest that an alteration in the executive functions was affecting the daily functioning of the girls with FXS to a greater extent.

scholarly journals The Relationship of Psychiatric Symptoms with Performance-Based and Self-Reported Cognitive Function After Ischemic Stroke

2021 ◽  
pp. 1-13
Author(s):  
Elisabeth Kliem ◽  
Elise Gjestad ◽  
Truls Ryum ◽  
Alexander Olsen ◽  
Bente Thommessen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Executive Function ◽  
Depressive Symptoms ◽  
Cognitive Function ◽  
Psychiatric Symptoms ◽  
Post Stroke ◽  
Cognitive Difficulties ◽  
Memory And Attention ◽  
Relationship Of ◽  
The Relationship

Abstract Objective: Findings on the relationship of psychiatric symptoms with performance-based and self-reported cognitive function post-stroke are inconclusive. We aimed to (1) study the relation of depression and anxiety to performance-based cognitive function and (2) explore a broader spectrum of psychiatric symptoms and their association with performance-based versus self-reported cognitive function. Method: Individuals with supratentorial ischemic stroke performed neuropsychological examination 3 months after stroke. For primary analyses, composite scores for memory and attention/executive function were calculated based on selected neuropsychological tests, and the Hospital Anxiety and Depression Scale (HADS) was used. Psychiatric symptoms and self-reported cognitive function for secondary aims were assessed using the Symptom-Checklist-90 – Revised (SCL-90-R). Results: In a sample of 86 patients [mean (M) age: 64.6 ± 9.2; Mini-Mental State Examination (MMSE), 3–7 days post-stroke: M = 28.4 ± 1.7; National Institutes of Health Stroke Scale (NIHSS) after 3 months: M = 0.7 ± 1.6] depressive symptoms (HADS) were associated with poorer memory performance after controlling for age, sex, and education (p ≤ .01). In a subsample (n = 41; Age: M = 65.7 ± 8.1; MMSE: M = 28.4 ± 1.8; NIHSS: M = 1.0 ± 1.9), symptoms of phobic anxiety (SCL-90-R) were associated with poorer performance-based memory and attention/executive function, and symptoms of anxiety (SCL-90-R) with lower attention/executive function. Higher levels of self-reported cognitive difficulties were associated with higher scores in all psychiatric domains (p ≤ .05). Conclusion: Even in relatively well-functioning stroke patients, depressive symptoms are associated with poorer memory. The results also suggest that various psychiatric symptoms are more related to self-reported rather than to performance-based cognitive function. Screening for self-reported cognitive difficulties may not only help to identify patients with cognitive impairment, but also those who need psychological treatment.

Emotional availability in women with bipolar disorder and major depression: A longitudinal pregnancy cohort study

2021 ◽  
pp. 000486742199879
Author(s):  
Pavitra Aran ◽  
Andrew J Lewis ◽  
Stuart J Watson ◽  
Thinh Nguyen ◽  
Megan Galbally
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Depressive Disorder ◽  
Emotional Availability ◽  
Major Depressive ◽  
Interaction Quality ◽  
Pregnancy Cohort ◽  
The Impact

Objective: Poorer mother–infant interaction quality has been identified among women with major depression; however, there is a dearth of research examining the impact of bipolar disorder. This study sought to compare mother–infant emotional availability at 6 months postpartum among women with perinatal major depressive disorder, bipolar disorder and no disorder (control). Methods: Data were obtained for 127 mother–infant dyads from an Australian pregnancy cohort. The Structured Clinical Interview for the DSM-5 was used to diagnose major depressive disorder ( n = 60) and bipolar disorder ( n = 12) in early pregnancy (less than 20 weeks) and review diagnosis at 6 months postpartum. Prenatal and postnatal depressive symptoms were measured using the Edinburgh Postnatal Depression Scale, along with self-report psychotropic medication use. Mother and infant’s interaction quality was measured using the Emotional Availability Scales when infants reached 6 months of age. Multivariate analyses of covariance examining the effects of major depressive disorder and bipolar disorder on maternal emotional availability (sensitivity, structuring, non-intrusiveness, non-hostility) and child emotional availability (responsiveness, involvement) were conducted. Results: After controlling for maternal age and postpartum depressive symptoms, perinatal disorder (major depressive disorder, bipolar disorder) accounted for 17% of the variance in maternal and child emotional availability combined. Compared to women with major depressive disorder and their infants, women with bipolar disorder and their infants displayed lower ratings across all maternal and child emotional availability qualities, with the greatest mean difference seen in non-intrusiveness scores. Conclusions: Findings suggest that perinatal bipolar disorder may be associated with additional risk, beyond major depressive disorder alone, to a mother and her offspring’s emotional availability at 6 months postpartum, particularly in maternal intrusiveness.

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