Correlation of Negative Symptoms in Schizophrenia with Frontal Lobe Parameters on Magnetic Resonance Imaging

1991 ◽  
Vol 159 (1) ◽  
pp. 130-134 ◽  
Author(s):  
P. Williamson ◽  
D. Pelz ◽  
H. Merskey ◽  
S. Morrison ◽  
P. Conlon
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tardive Dyskinesia ◽  
Frontal Lobe ◽  
Negative Symptoms ◽  
Positive Symptoms ◽  
Resonance Imaging ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients

Among 24 chronic schizophrenic patients, the 10 with high ratings for negative symptoms had significantly higher left-frontal: temporal–cortical T2 ratios. This finding was unrelated to age, dose of medication, length of illness or handedness. No T1 or T2 changes were found to be associated with positive symptoms or tardive dyskinesia in the regions examined.

Magnetic resonance imaging studies of tardive dyskinesia in schizophrenic patients

1989 ◽  
Vol 2 (1-2) ◽  
pp. 116 ◽  
Author(s):  
George Bartzokis ◽  
Jordan Garber ◽  
StephenR. Marder ◽  
WilliamH. Oldendorf
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tardive Dyskinesia ◽  
Resonance Imaging ◽  
Imaging Studies ◽  
Schizophrenic Patients

Tardive Dyskinesia in Schizophrenia: Relationship to Minor Physical Anomalies, Frontal Lobe Dysfunction and Cerebral Structure on Magnetic Resonance Imaging

1995 ◽  
Vol 167 (1) ◽  
pp. 41-44 ◽  
Author(s):  
John L. Waddington ◽  
Eadbhard O'Callaghan ◽  
Peter Buckley ◽  
Cathy Madigan ◽  
Oonagh Redmond ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tardive Dyskinesia ◽  
Frontal Lobe ◽  
Disease Process ◽  
Wisconsin Card Sorting Test ◽  
Cortical Atrophy ◽  
Resonance Imaging ◽  
Cerebral Structure ◽  
Minor Physical Anomalies

BackgroundIt was hypothesised that schizophrenic patients with tardive dyskinesia show an excess of neurodevelopmental disturbance, particularly minor physical anomalies, in association with cognitive dysfunction and abnormalities of cerebral structure.MethodForty-seven out-patients with a DSM–III diagnosis of schizophrenia were examined for tardive dyskinesia using the Abnormal Involuntary Movement Scale; they were examined also for minor physical anomalies and neuropsychological test performance. Cortical atrophy, signal hyperintensities and lateral ventricular volume were determined on magnetic resonance imaging.ResultsPatients with and without tardive dyskinesia could not be distinguished by age, gender distribution or a number of clinical measures; however, patients with tardive dyskinesia sorted fewer categories on the Wisconsin Card Sorting Test (P = 0.04). Cerebral structure in patients with and without tardive dyskinesia could not be distinguished on magnetic resonance imaging but those with dyskinesia, all of whom showed involvement of the orofacial region, showed more evident minor physical anomalies of the head relative to those of the periphery (P = 0.02).ConclusionsTardive orofacial dyskinesia in schizophrenia appears to be associated particularly with poorer frontal lobe function, while predominance of craniofacial dysmorphogenesis may constitute a vulnerability factor that is related to the early origins of the disease process.

Ventral Frontal Cortex Morphology in Adult Males with Isolated Orofacial Clefts: Relationship to Abnormalities in Social Function

2005 ◽  
Vol 42 (2) ◽  
pp. 138-144 ◽  
Author(s):  
Peg Nopoulos ◽  
Ian Choe ◽  
Stephanie Berg ◽  
Duane Van Demark ◽  
John Canady ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Frontal Cortex ◽  
Frontal Lobe ◽  
Orbitofrontal Cortex ◽  
Brain Region ◽  
Social Function ◽  
Structural Abnormality ◽  
Adult Males ◽  
Resonance Imaging

Objective In a previous magnetic resonance imaging (MRI) study, men with nonsyndromic clefts of the lip and/or palate (NSCLP) were found to have abnormalities in the structure of the frontal lobe of the brain. Moreover, many subjects with nonsyndromic clefts of the lip and/or palate have been described as being socially inhibited. A subregion of the frontal lobe, the ventral frontal cortex (VFC), has been shown to be related to social function. This study was designed to evaluate the morphology of the ventral frontal cortex in men with nonsyndromic clefts of the lip and/or palate, and the morphology's relationship to social function. Methods Subjects were 46 men with nonsyndromic clefts of the lip and/or palate and 46 sex matched controls. Social function was assessed using a standardized scale. The morphology of the ventral frontal cortex (composed of the orbitofrontal cortex [OFC] and the straight gyrus [SG]) was obtained from magnetic resonance imaging scans using the software BRAINS. Results After controlling for frontal lobe gray matter, the patient group had significant reductions in orbitofrontal cortex volume and area. The straight gyrus was not morphologically abnormal. Measures of orbitofrontal cortex morphology were significantly correlated to measures of social function—the greater the structural abnormality, the greater the social dysfunction. Conclusion Compared with healthy controls, subjects with nonsyndromic clefts of the lip and/or palate showed morphologic abnormalities in the cortical surface anatomy of a brain region known to govern social function, the orbitofrontal cortex. Moreover, the structural abnormality in this brain region was directly correlated with social function.

scholarly journals An Unusual Case of Unilateral Papilledema

2019 ◽  
Vol 3 (4) ◽  
pp. 444-445
Author(s):  
Daniel Quesada ◽  
Matthew Stapleton ◽  
Jadipak Heer ◽  
Phillip Aguìñiga-Navarrete ◽  
Luke Kim
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebrospinal Fluid ◽  
Magnetic Resonance ◽  
Frontal Lobe ◽  
Unusual Case ◽  
Vision Loss ◽  
Physical Exam ◽  
Fluid Density ◽  
Resonance Imaging

Neuroretinitis from neurosyphilis is an uncommon finding in previously healthy young individuals. A 37-year-old presented with three days of painless, unilateral vision loss with an associated diffuse erythematous non-pruritic truncal rash. Physical exam demonstrated vision loss in the left eye. Fundoscopic exam showed unilateral peripapillary hemorrhage, papilledema and venous engorgement. Labs showed positive syphilis antibody qualitative. Magnetic resonance imaging demonstrated 12 millimeters of high right frontal lobe cerebrospinal fluid density. The patient was treated with benzylpenicillin and within 18 hours had improvement of his vision.

Measurement of frontal lobe volume on magnetic resonance imaging scans

1997 ◽  
Vol 75 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Elizabeth H. Aylward ◽  
Ann Augustine ◽  
Qiang Li ◽  
Patrick E. Barta ◽  
Godfrey D. Pearlson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Frontal Lobe ◽  
Resonance Imaging

scholarly journals Latent Schizencephaly With Psychotic Phenotype or Schizophrenia With Schizencephaly? A Case Report and Review of the Literature

2018 ◽  
Vol 50 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Filip Tylš ◽  
Martin Brunovský ◽  
Kateřina Šulcová ◽  
Barbora Kohútová ◽  
Zuzana Ryznarová ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Magnetic Resonance ◽  
Negative Symptoms ◽  
First Episode ◽  
Resonance Imaging ◽  
Predisposing Factor ◽  
Perinatal Pathology ◽  
Initial Symptoms ◽  
Rhythmic Delta Activity

Objectives. Although schizencephaly belongs to the class of neurodevelopmental disorders, which are a well-known predisposing factor for psychosis, there is a lack of relevant studies and diagnostic guidelines on this relationship. Method. A case report of first-episode psychosis with persistent negative symptoms associated with schizencephaly is described and compared with 7 other cases found in the literature. Results. We found perinatal pathology, cognitive deficit, and EEG abnormality in a patient with atypical initial symptoms of psychosis such as olfactory hallucinations. Abnormal EEG findings (left frontal spikes and frontal intermittent rhythmic delta activity) called for magnetic resonance imaging, which revealed left parieto-occipital closed-lip schizencephaly. The patient exhibited a partial response to low-dose amisulpride treatment. Conclusion. We conclude that schizencephaly in our patient was at first asymptomatic and later developed into clinically manifest schizophrenia-like disorder. Both magnetic resonance imaging and EEG were essential tools for establishing this diagnosis.

Movement disorders and psychological tests of frontal lobe function in schizophrenic patients

1992 ◽  
Vol 22 (1) ◽  
pp. 69-77 ◽  
Author(s):  
K. W. Brown ◽  
T. White ◽  
D. Palmer
Keyword(s):  
Tardive Dyskinesia ◽  
Frontal Lobe ◽  
Movement Disorders ◽  
Neuropsychological Tests ◽  
Psychological Tests ◽  
Chronic Schizophrenic ◽  
Frontal Lobe Function ◽  
Schizophrenic Patients ◽  
Frontal Lobe Functions ◽  
Psychological Functions

SYNOPSISNeuropsychological tests of frontal lobe functions were undertaken in 46 chronic schizophrenic patients who were also rated for movement disorders. Tardive dyskinesia was found to have significant associations with most of these psychological tests. The possible mechanisms are discussed within the context of known neostriatal psychological functions.

scholarly journals A systematic review of brain frontal lobe parcellation techniques in magnetic resonance imaging

2013 ◽  
Vol 219 (1) ◽  
pp. 1-22 ◽  
Author(s):  
Simon R. Cox ◽  
Karen J. Ferguson ◽  
Natalie A. Royle ◽  
Susan D. Shenkin ◽  
Sarah E. MacPherson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Systematic Review ◽  
Magnetic Resonance ◽  
Frontal Lobe ◽  
Resonance Imaging
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