A Family Study of Two Subgroups of Schizoaffective Patients

1989 ◽  
Vol 154 (5) ◽  
pp. 640-643 ◽  
Author(s):  
Mario Maj
Keyword(s):  
High Risk ◽  
Psychiatric Disorders ◽  
Schizoaffective Disorder ◽  
Clinical Picture ◽  
Affective Disorders ◽  
Family Study ◽  
The Other ◽  
Schizoaffective Disorders ◽  
First Degree Relatives ◽  
Group A

A family study was carried out in two groups of patients fulfilling RDC for schizoaffective disorder: in one, a full affective and a full schizophrenic syndrome were simultaneously present; in the other, affective and schizophrenic features appeared within a polymorphic and rapidly changing clinical picture, with depersonalisation/derealisation and/or confusion. In the first-degree relatives of patients of the former group, the risk of major psychiatric disorders was not significantly different from that of relatives of schizophrenics, whereas in the first-degree relatives of patients of the latter group a low risk for both schizophrenia and major affective disorders, and a relatively high risk for schizoaffective disorders, were observed.

Four electrophoretic methods compared for diagnosis of type III hyperlipoproteinemia.

1979 ◽  
Vol 25 (8) ◽  
pp. 1471-1475 ◽  
Author(s):  
K Kuba ◽  
K Lippel ◽  
I D Frantz
Keyword(s):  
Family Study ◽  
Paper Electrophoresis ◽  
Polyacrylamide Gel ◽  
The Other ◽  
Lipid Research ◽  
Central Laboratory ◽  
Type Iii ◽  
First Degree Relatives ◽  
Type Iii Hyperlipoproteinemia ◽  
Precipitation Technique

Abstract Blood drawn from 192 probands and 1129 first-degree relatives who were participants in a collaborative family study of hyperlipoproteinemia at nine Lipid Research Clinics was used to prepare aliquots of whole plasma and top (d less than 1.006 g/mL) and bottom (d greater than 1.006 g/mL) ultracentrifugal fractions. Each aliquot was analyzed at a central laboratory by electrophoresis on paper, agarose, and polyacrylamide gel, and by a combined electrophoretic precipitation technique. The electrophoretograms were evaluated for the presence or absence of a "floating-beta" lipoprotein band. All four methods agreed completely for 92.3% of the samples. An additional 2.0% of the samples were in agreement for three electrophoretic methods, but the paper electrophoretic results were not interpretable. Another 1.9% were considered to be "floating-beta" positive by paper electrophoresis but negative by the other three electrophoretic methods.

Conservative Chemotherapy in Gestational Trophoblastic Disease: Experience With Etoposide, Methotrexate, and Dactinomycin Chemotherapy

2016 ◽  
Vol 26 (4) ◽  
pp. 790-795 ◽  
Author(s):  
Seung Won Byun ◽  
Tae Chul Park ◽  
Seog Nyeon Bae
Keyword(s):  
High Risk ◽  
Gestational Trophoblastic Disease ◽  
Low Risk ◽  
The Other ◽  
World Health ◽  
Who Grade ◽  
Trophoblastic Disease ◽  
Group A ◽  
Group B ◽  
Health Organization

ObjectiveThe goal of this study was to evaluate the efficacy, toxicity, and survival of patients in our institution treated by EMA (etoposide, methotrexate [MTX], and dactinomycin) chemotherapy for 3 groups of patients: ones that had low-risk gestational trophoblastic disease (GTD) that was resistant to MTX (group A), those with high-risk GTD (group B), and the group having low-risk GTD but the cancer being metastatic (group C).MethodsThe medical records of 58 patients who received EMA chemotherapy in groups A, B, and C in the 2000 to 2012 period at St Mary’s Hospital were examined. Clinical characteristics, chemotherapy responses, causes of treatment failure, and cases of drug toxicity were analyzed retrospectively.ResultsTreatment with the EMA regimen resulted in primary remission in 52 (96%) of 54 patients and resistance in 2 of the patients (3%). In the resistance group, one belonged to group B and was treated with etoposide, MTX, and actinomycin D with cyclophosphamide and vincristine (EMA-EP) and the other belonged to group A and died of refractory disease. World Health Organization (WHO) grade 4 leukocytopenia and thrombocytopenia with the EMA regimen occurred in 6% and 0.4% of the cycles, respectively; the other toxic effects were acceptable and manageable. Median cycles of EMA chemotherapy during the treatment were 7, 8, and 8 in groups A, B, and C, respectively. There was some reduction in total chemo cycle and toxicity, as compared with a previously reported study using the alternative cyclophosphamide and vincristine regimen. Among the EMA treated patients, 1 patient with a second malignancy of breast cancer was documented. In addition, 5 child births for the treated patients were recorded during the follow-up period of mostly 10 years.ConclusionsThe EMA chemotherapy seemed to reduce treatment duration and the relapse rate without increasing the adverse effects in patients with MTX resistance and low-risk GTD, but having confirmed metastatic lesions. Although this study had some limitations regarding the high-risk GTD, our findings will provide a basis for the use of EMA chemotherapy when cyclophosphamide and vincristine is contraindicated due to toxicity.

Psychiatric Illnesses in the Families of Female Criminals: A Study of 288 First-Degree Relatives

1973 ◽  
Vol 122 (571) ◽  
pp. 697-703 ◽  
Author(s):  
C. Robert Cloninger ◽  
Samuel B. Guze
Keyword(s):  
General Population ◽  
Psychiatric Disorders ◽  
Drug Dependence ◽  
Psychiatric Diagnosis ◽  
The Other ◽  
Psychiatric Illnesses ◽  
First Degree Relatives ◽  
Female Criminals

Sociopathy, alcoholism, and drug dependence have been shown to be the only psychiatric disorders more frequent among convicted male felons than in the general population (4, 5). In these studies, sociopathy, regardless of other disorders, was found in nearly 80 per cent. An increased prevalence of sociopathy, alcoholism, drug dependence, and hysteria, or Briquet's Syndrome (3), was found among the first-degree relatives of these felons; hysteria (Briquet's Syndrome) among the female relatives and the other disorders predominantly among the male relatives. Overall, 44 per cent of the male felons' first-degree relatives received a psychiatric diagnosis (6).

Morbidity Risks of Schizophrenia and Affective Disorders among First-Degree Relatives of Patients with Schizoaffective Disorders

1991 ◽  
Vol 158 (2) ◽  
pp. 165-170 ◽  
Author(s):  
Ming T. Tsuang
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Clinical Characteristics ◽  
Heterogeneous Group ◽  
Family Data ◽  
Schizoaffective Disorders ◽  
First Degree Relatives ◽  
Morbidity Risks ◽  
Research Criteria

Of 510 patients consecutively admitted and diagnosed as schizophrenic, 310 who failed to meet research criteria for schizophrenia were labelled as having ‘atypical psychosis'. This heterogeneous group of patients was then subtyped into more homogeneous subgroupings according to their clinical characteristics, independent of their family data. One subgroup resembled schizophrenia, one resembled affective disorders and a third (n = 57), which did not resemble either schizophrenia or affective disorder, was defined as ‘schizoaffective’. Comparing the morbidity risks for schizophrenic and affective disorders in the relatives of this schizoaffective group with those of the relatives of ‘typical’ groups of schizophrenia and affective disorder, showed that this group was different from those with schizophrenic and affective disorders.

Genetic Implications in Assortative Mating of Affective Disorders

1981 ◽  
Vol 138 (3) ◽  
pp. 236-239 ◽  
Author(s):  
Enrico Smeraldi ◽  
Fiammetta Negri ◽  
Anna Maria Melica ◽  
Rosanna Zuliani ◽  
Mariangela Gasperini ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Assortative Mating ◽  
Affective Disorders ◽  
Psychiatric Illnesses ◽  
Control Subjects ◽  
First Degree Relatives ◽  
Spectrum Disorders ◽  
Primary Affective Disorders

SummaryPsychiatric disorders in a sample of spouses of probands with recurrent Primary Affective Disorders (PAD) and in their first degree relatives were evaluated and compared with those in the spouses of control subjects without psychiatric illnesses. No differences were found in the risk for PAD, but spouses of PAD patients and their respective first degree relatives manifested a greater incidence of affective spectrum disorders.

The relationship between bipolar disorder and alcoholism: a controlled family study

1995 ◽  
Vol 25 (4) ◽  
pp. 787-796 ◽  
Author(s):  
W. Maier ◽  
D. Lichtermann ◽  
J. Minges ◽  
C. Delmo ◽  
R. Heun
Keyword(s):  
Bipolar Disorder ◽  
Affective Disorders ◽  
Family Study ◽  
Familial Risk ◽  
Multiple Sources ◽  
Distinct Subgroup ◽  
First Degree Relatives ◽  
Familial Risk Factors ◽  
The Relationship ◽  
Familial Disorders

SYNOPSISBipolar disorder and alcoholism are familial disorders. The familial–genetic relationship between both is controversial and has received insufficient study. This study explores whether bipolar disorder and alcoholism share familial risk factors, and whether the co-occurrence of lifetime diagnosis of bipolar disorder and alcoholism is familial. We report on first-degree relatives of 146 consecutively admitted patients with either bipolar disorder or/and alcoholism; relatives of the patients (in total 728 relatives directly interviewed) were compared with first-degree relatives of 109 general population probands (320 relatives directly interviewed). Overlap between the familial components underlying bipolar disorder and alcoholism was not observed if the analysis was restricted to ‘pure’ diagnostic groups. Excess comorbidity between bipolar disorder and alcoholism was observed in relatives. Multiple sources for this excess of comorbidity between major affective disorders and alcoholism in families of probands with bipolar disorder are likely; in particular, we found evidence for a distinct subgroup of comorbid cases with familial comorbidity; however, excess comorbidity was also found in absence of familial loading with alcoholism.

scholarly journals Familial associations for rheumatoid autoimmune diseases

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Hauke Thomsen ◽  
Xinjun Li ◽  
Kristina Sundquist ◽  
Jan Sundquist ◽  
Asta Försti ◽  
...  
Keyword(s):  
High Risk ◽  
Autoimmune Diseases ◽  
Sex Difference ◽  
Family Study ◽  
Familial Risk ◽  
Disease Onset ◽  
Complex Diseases ◽  
The Other ◽  
Genetic Pathways ◽  
Study Designs

Abstract Objective Previous studies have shown a familial component in RA and in some other rheumatic autoimmune diseases (RAIDs), but because of the different study designs the risk estimates for familial risks differ extensively. The objective of this study is to identify familial components for RAIDs. Methods We collected data on patients diagnosed in Swedish hospitals with RA, AS, PM/DM, SS, SLE and SSc (and scleroderma) and calculated familial standardized incidence ratios (SIRs) for each of these (concordant) and between them (discordant). Results The combined number of RAID patients in the offspring population (for whom SIRs were calculated) was 71 544, and in the whole population the number was 152 714, accounting for 19.8% of all autoimmune diseases in Sweden. AS showed the highest concordant familial risk of 18.42, followed by SLE (14.04), SS (8.63), SSc (4.50), PM/DM (4.03) and RA (3.03). There was no sex difference in SIRs. Risks for AS and SLE were 80.28 and 19.53 for persons whose parents and siblings were affected. Discordant risks were far lower than concordant risks, but they were significant for RA with all the other five RAIDs, for SLE and SSc with four RAIDs, for AS and SS with three RAIDs and for PM/DM with two RAIDs, attesting to extensive polyautoimmunity between RAIDs. Conclusion The derived familial risks in this nationwide family study on medically diagnosed RAID are compatible with emerging evidence on the polygenic background of these complex diseases. Novel genetic pathways offer new therapeutic targets that alleviate disease onset optimally in high-risk familial patients and others.

Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽  
1999 ◽  
Vol 20 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Tamás Zonda
Keyword(s):  
High Risk ◽  
Psychiatric Disorders ◽  
Suicide Rate ◽  
Risk Groups ◽  
The Elderly ◽  
Female Ratio ◽  
Suicide Notes ◽  
Suicidal Intention ◽  
Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

Tonsillar Inflammation, a Rare Cause of Bradycardia and Hypotension

2018 ◽  
Vol 3 (3) ◽  
Keyword(s):  
Streptococcus Pyogenes ◽  
Fusobacterium Necrophorum ◽  
Outpatient Setting ◽  
Peritonsillar Abscess ◽  
The Other ◽  
Streptococcus Group ◽  
Other Hand ◽  
Group A

Tonsillitis is a frequently encountered pathology in the outpatient setting, usually caused by viruses [1]. When bacterial, the most common causatory microbe is streptococcus group A [1]. Tonsillar and peritonsillar abscess (PTA) on the other hand are never viral, and are usually caused by streptococcus pyogenes, Streptococcus melleri, fusobacterium necrophorum and staphylococci [1,2]. The overall incidence of PTA is suggested to be 37/100,000 patients, with the highest incidence between ages 14-21 at 124/100,000 [3].

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